A5062076220- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Immunology Research
- Transgenic Plants and Applications
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Insect Resistance and Genetics
- Plant Virus Research Studies
- Plant tissue culture and regeneration
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- vaccines and immunoinformatics approaches
- Blood groups and transfusion
- Influenza Virus Research Studies
- Autism Spectrum Disorder Research
- Viral gastroenteritis research and epidemiology
- Invertebrate Immune Response Mechanisms
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Respiratory viral infections research
- RNA regulation and disease
- Tuberculosis Research and Epidemiology
- Insect and Pesticide Research
Instituto de Biotecnología y Biología Molecular
2021-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2024
National Agricultural Technology Institute
1990-2020
National Institute of Industrial Technology
2000-2011
Instituto de Biotecnología de León
2010
Instituto de Investigaciones Agropecuarias
2002
Instituto Nacional de Tecnologia
1990-2001
Plum Island Animal Disease Center
1995-1996
United States Department of Agriculture
1996
The amino acid sequence Arg-Gly-Asp (RGD) is highly conserved on the VP1 proteins of different serotypes and subtypes foot-and-mouth disease virus (FMDV) essential for cell attachment. This also found in certain extracellular matrix that bind to a family surface receptors called integrins. Within Picornaviridae family, enterovirus coxsackievirus A9 has an RGD motif its capsid protein recently been shown utilize vitronectin receptor integrin alpha V beta 3 as monkey kidney cells. Competition...
To gain entry into cells, viruses utilize a variety of different cell-surface molecules. Foot-and-mouth disease virus (FMDV) binds to integrin molecules via an arginine-glycine-aspartic acid (RGD) sequence in capsid protein VP1. Binding this particular molecule influences FMDV tropism, and virus/receptor interactions appear be responsible, part, for selection antigenic variants. study early events virus-cell interaction, we engineered alternative novel receptor FMDV. Specifically, generated...
In this work we analyze the antigenic properties and stability in cell culture of virus mutants recovered upon challenge peptide-vaccinated cattle with foot-and-mouth disease (FMDV) C3 Arg85. Previously, showed that a significant proportion 29 lesions analyzed (41%) contained viruses single amino acid replacements (R141G, L144P, or L147P) within major site located at G-H loop VP1, known to participate also interactions integrin receptors. Here document no were found from 12 developed six...
Newcastle disease virus (NDV) is the causative agent of an economically important disease, which affects all species birds worldwide. Current vaccination programs for NDV include use either low-virulent live-virus vaccines or inactivated to induce protective immunity while producing minimal adverse effects in birds. In order further characterize immune response elicited by live and conventional chickens, we evaluated presence specific antibodies different secretions tissue culture...
Wild waterfowl is considered a natural reservoir of potentially infectious agents and source pathogenic viruses like avian paramyxoviruses type 1 (APMV 1). In 1997, commercial poultry in Argentina had reached the status being free from virulent Newcastle disease virus (NDV) infections. Vaccination biosecurity measures are actively performed to maintain this preferential sanitary condition. However, risk reintroduction always present. context, we conducted study describe wild healthy birds...
ABSTRACT Newcastle disease virus (NDV) is an economically important pathogen of poultry that may cause clinical ranges from a mild respiratory syndrome to virulent form with high mortality, depending on isolate's pathotype. Infections NDV strains are required be reported by member nations the Office International Epizootes (OIE). The primary determinant for virulence among isolates presence or absence dibasic amino acids in fusion (F) protein cleavage activation site. Along biological...
Infectious bursal disease virus (IBDV) is the etiological agent of an immunosuppressive and highly contagious that affects young birds causing important economic losses in poultry industry worldwide. We have previously developed a plant-based vaccine candidate for infectious (IBD) able to protect against infection with IBDV when administered through intramuscular (im) route. Given oral vaccination non-invasive stimulates immunity mucosal gastrointestinal surface, initial site contact entry...
In this report, we describe the biological and molecular characterization of a paramyxovirus type-1 (PPMV-1) isolate found in wild pigeons an urban habitat Buenos Aires, Argentina. Of nine captured, three were moribund, other six showed diarrhea, ataxia, tremor, torticolis, wing paralysis. The intracerebral pathogenicity index was 1.29, amino acid (aa) sequence at fusion protein cleavage site 112GRQ KRF117. These characteristics correspond to virulent Newcastle disease virus isolate....
Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development implementation of new vaccines remains prohibitively expensive for middle low income countries where such measures are surely needed most. The production plant-based provides a promising alternative create affordable biological products. In past decade, growing number research groups worldwide have studied plant expression parenteral or oral delivery vaccine antigens, some...