A5101711406- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Animal Disease Management and Epidemiology
- Transgenic Plants and Applications
- Viral gastroenteritis research and epidemiology
- Invertebrate Immune Response Mechanisms
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Entomopathogenic Microorganisms in Pest Control
- Vector-Borne Animal Diseases
- Poxvirus research and outbreaks
- bioluminescence and chemiluminescence research
- Protein purification and stability
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Immunotherapy and Immune Responses
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2022
National Agricultural Technology Institute
2011-2022
Instituto de Agrobiotecnología del Litoral
2020
Centro Científico Tecnológico - San Juan
2014-2017
Instituto de Biotecnología de León
2007
Centro Científico Tecnológico - Tucumán
2007
Baculoviruses (BV) are DNA viruses that pathogenic for insects. Although BV infect a range of mammalian cell types, they do not replicate in these cells. Indeed, the potential effects insect on immune responses mammals only just beginning to be studied. We show this paper recombinant Autographa californica multiple nuclear polyhedrosis virus carrying fragment ovalbumin (OVA) VP39 capsid protein (BV-OVA) has capacity act as an adjuvant and vector antigens mice, thereby promoting specific CD4...
In order to improve the presentation and immunogenicity of single epitopes, virus-like particles (VLPs) are being used as platforms for display foreing epitopes on their surface. The rotavirus major capsid protein VP6 has ability self-assemble into empty non-infectious VLPs. present study, we analyzed use double layered VLPs (made up VP2 proteins) carriers a 14 amino acid epitope fused three different aminoacidic regions exposed surface Although all chimeric were correctly expressed in...
The budded phenotype (BV) of the baculovirus AcMNPV has been demonstrated to have strong immunostimulatory properties that are relevant for development vaccines and antiviral therapies. Although occluded (ODV) shares main structural proteins its genome with BV, it poorly studied in mammals. In this study, we assessed capacity ODV induce immune responses mice. contrast BVs, ODVs failed promote secretion IFN-gamma, IL-6 Il-12 activity against VSV short term. Furthermore, were unable cellular...
Abstract Although the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, represents an efficient vector for vaccine development. Baculovirus surface display induces strong humoral responses against viruses and parasites. A novel strategy based on capsid carrying foreign antigens in AcMNPV particle further improved immune response by eliciting CD8 + T cell activation. In this study, we analyze intracellular...
Recent studies have shown adjuvant properties of baculovirus by enhancing and modulating the immune response in mammals. This ability has been explained part activation innate immunity. In addition, induce a vigorous cytotoxic characterized large number IFNγ-producing cells. By flow cytometry analysis, we demonstrated that, when inoculated mice, wild type IFNγ IL-12 expression NK NKT manipulating baculovirus' genome via homologous recombination it is possible to display multiple copies...