A5053388943- Carbohydrate Chemistry and Synthesis
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Enzyme Production and Characterization
- Herpesvirus Infections and Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Cancer Treatment and Pharmacology
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Lysosomal Storage Disorders Research
- Advanced Drug Delivery Systems
- Influenza Virus Research Studies
- Cancer therapeutics and mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Breast Lesions and Carcinomas
- Viral Infections and Vectors
The University of Queensland
2016-2025
University of Palermo
2024
Australian e-Health Research Centre
2022
Brisbane School of Theology
2015-2020
Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni
2018
Weatherford College
2013
Cold Spring Harbor Laboratory
2012
Alcohol and Drug Foundation
2009-2012
The University of Western Australia
1994-2012
UNSW Sydney
2012
The dependence of development and homeostasis in animals on the interaction hundreds extracellular regulatory proteins with peri- glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means adherence invasion. Heparin, widely used anticoagulant drug, structurally similar to HS common experimental proxy. Exogenous heparin prevents infection range viruses, including S-associated coronavirus isolate HSR1. Here, we show that inhibits severe acute respiratory...
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as coreceptor with the ACE2 protein for S1 spike on SARS-CoV-2 virus, providing tractable new therapeutic target. Clinically used heparins demonstrate an inhibitory activity but have anticoagulant and are supply-limited, necessitating alternative solutions. Here, we show that synthetic HS mimetic pixatimod (PG545), cancer drug candidate, binds destabilizes receptor binding domain directly inhibits its to ACE2,...
PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix (ECM), thus limiting subsequent binding to receptors. Importantly, also heparanase, only endoglycosidase which cleaves HS chains ECM. The aim of study was assess various solid and metastasis models. anti-angiogenic, anti-tumour anti-metastatic properties were assessed using vivo angiogenesis, Pharmacokinetic (PK) data generated tumour-bearing mice...
Abstract Bone marrow–derived endothelial progenitor cells (EPC) contribute to the angiogenesis-dependent growth of tumors in mice and humans. EPCs regulate angiogenic switch via paracrine secretion proangiogenic factors by direct luminal incorporation into sprouting nascent vessels. miRNAs have emerged as key regulators several cellular processes including angiogenesis; however, whether bone marrow–mediated angiogenesis has remained unknown. Here, we show that genetic ablation...
Increasing the aglycone lipophilicity of a series polysulfated oligosaccharide glycoside heparan sulfate (HS) mimetics via attachment steroid or long chain alkyl group resulted in compounds with significantly improved vitro and ex vivo antiangiogenic activity. The potently inhibited heparanase HS-binding angiogenic growth factors displayed antitumor antimetastatic activity compared earlier series. Preliminary pharmacokinetic analyses also revealed significant increases half-life following iv...
Herein, the degradation of low molecular weight chitosan (CS), with 92% degree deacetylation (DD), and its nanoparticles (NP) has been investigated in 0.2 mg/mL lysozyme solution at 37 °C. The CS were prepared using glutaraldehyde crosslinking a water-in-oil emulsion system. morphological characterization particles was carried out scanning electron microscopy (SEM) Transmission Electron Microscopy (TEM) techniques. Using attenuated total reflectance Fourier transform infrared (ATR-FTIR)...
SARS-CoV-2 has rapidly spread throughout the world's population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on surface. primarily binds to angiotensin-converting enzyme-2 (ACE2) receptor, using glycosaminoglycans (GAGs) as co-receptors. Here, we performed bioinformatics and molecular dynamics simulations of investigate existence additional GAG binding sites receptor-binding domain (RBD), separate from previously reported...
A series of polysulfated penta- and tetrasaccharide glycosides containing α(1→3)/α(1→2)-linked mannose residues were synthesized as heparan sulfate (HS) mimetics evaluated for their ability to inhibit angiogenesis. The compounds bound tightly angiogenic growth factors (FGF-1, FGF-2, VEGF) strongly inhibited heparanase activity. In addition, the exhibited potent activity in cell-based ex vivo assays indicative angiogenesis, with tetrasaccharides exhibiting comparable that pentasaccharides....
This study investigated l-leucine-conjugated chitosan as a drug delivery vehicle in terms of dispersibility and controlled release from nanoparticulate dry powder inhaler (DPI) formulation for pulmonary using diltiazem hydrochloride (DH) the model drug. DH-loaded nanoparticles conjugate were prepared by water-in-oil emulsification followed glutaraldehyde cross-linking. Nanoparticles characterized dynamic light scattering particle size, X-ray photoelectron spectroscopy surface composition,...
The phosphosulfomannan 1 (PI-88) is a mixture of highly sulfated oligosaccharides that currently undergoing clinical evaluation in cancer patients. As well as its anticancer properties, displays number other interesting biological activities. A series analogues were synthesized with single carbon (pentasaccharide) backbone to facilitate structural characterization and interpretation results. In fashion similar 1, all compounds able inhibit heparanase bind tightly the proangiogenic growth...
Abstract Thromboses are potentially fatal complication in malignant tumor diseases. Today, oral anticoagulants considered equivalent alternatives to low molecular weight heparin (LMWH) guideline‐based treatments of cancer‐associated thromboses. Nevertheless, debates on potential antitumorigenic activities beyond anticoagulation still highly relevant. However, disclosure targeted is complicated by the heterogeneous structure this glycosaminoglycan natural origin. Therefore, synthetic polymers...