A5071822392- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Diaphragmatic Hernia Studies
- Angiogenesis and VEGF in Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Advanced Glycation End Products research
- Pleural and Pulmonary Diseases
- Regulation of Appetite and Obesity
- Barrier Structure and Function Studies
- Dietary Effects on Health
- Hematological disorders and diagnostics
- Retinal Diseases and Treatments
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
University of Leeds
1970-2025
St James's University Hospital
2024
Diabetes, obesity, and Alzheimer’s disease (AD) are associated with vascular complications impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein–cleaving (APP-cleaving) enzyme 1 (BACE1), APP, β-amyloid (Aβ) linked development BACE1 Aβ accompany hyperglycemia hyperlipidemia. However, the causal relationship between obesity diabetes, Aβ, dysfunction is unclear. We report that diet-induced (DIO) in mice plasma Aβ42 correlated decreased NO...
Abstract During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for complications has attracted much attention continues be actively explored. The endothelium lines all blood vessels is close cells, including adipocytes. been suggested act paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), modulator white phenotype. show that...
Abstract Pericytes regulate vascular development, stability, and quiescence; their dysfunction contributes to diabetic retinopathy. To explore the role of insulin receptors in pericyte biology, we created receptor knockout mice (PIRKO) by crossing PDGFRβ-Cre with (Insr) floxed mice. Their neonatal retinal vasculature exhibited perivenous hypervascularity venular dilatation, plus increased angiogenic sprouting superficial deep layers. Pericyte coverage capillaries was unaltered periarterial...
Report2 May 2021Open Access Source DataTransparent process Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity Natalie J Haywood orcid.org/0000-0002-8762-7257 Faculty of Medicine and Health, Leeds Institute Cardiovascular Metabolic Medicine, University Leeds, UK Search for more papers by this author Cheukyau Luk Katherine I Bridge Michael Drozd Natallia Makava Anna Skromna Amanda Maccannell Claire H Ozber Nele Warmke Chloe G Wilkinson Nicole T...
Pericytes are vascular mural cells that support the microvasculature; their dysfunction contributes to diabetic retinopathy and has been linked obesity in humans. To explore role of pericyte insulin signalling on systemic metabolism we utilised male mice from our previously described PIR
There are at least two distinct types of thermogenic adipocyte in mammals: a pre-existing form established during development, termed classical brown adipocytes and an inducible form, 'beige' [1][2][3] .Various environmental cues can stimulate process frequently referred to as 'beiging' white adipose tissue (WAT), leading enhanced thermogenesis obesity resistance 4,5 .Whilst beiging WAT therapeutic goal for obesity-related complications has attracted much attention [6][7][8][9] ;...
Summary There are at least two distinct types of thermogenic adipocyte in mammals: a pre-existing form established during development, termed classical brown adipocytes and an inducible form, ‘beige’ 1–3 . Various environmental cues can stimulate process frequently referred to as ‘beiging’ white adipose tissue (WAT), leading enhanced thermogenesis obesity resistance 4, 5 Whilst beiging WAT therapeutic goal for obesity-related complications has attracted much attention 6–9 ; therapeutics...