A5049222028- Aortic aneurysm repair treatments
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Disease and Adiposity
- Vascular Procedures and Complications
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood properties and coagulation
- Cerebrovascular and Carotid Artery Diseases
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Peripheral Artery Disease Management
- Angiogenesis and VEGF in Cancer
- Protein Kinase Regulation and GTPase Signaling
- Atherosclerosis and Cardiovascular Diseases
- Genetic and Kidney Cyst Diseases
- Sirtuins and Resveratrol in Medicine
- Tuberous Sclerosis Complex Research
University of Leeds
2015-2025
London Bridge Hospital
2024
Leeds General Infirmary
2011-2022
Leeds Teaching Hospitals NHS Trust
2014
Unidad de Cirugía Artroscópica
2014
Enhanced Vision (United States)
2014
Pulmonary Vascular Research Institute
2014
Cork University Hospital
2014
University College Cork
2014
Information Technology University
2014
OBJECTIVE Obesity and diabetes frequently coexist, yet their individual contributions to cardiovascular risk remain debated. We explored disease biomarkers, events, mortality in the UK Biobank stratified by BMI diabetes. RESEARCH DESIGN AND METHODS A total of 451,355 participants were ethnicity-specific categories (normal, overweight, obese) status. examined biomarkers including carotid intima-media thickness (CIMT), arterial stiffness, left ventricular ejection fraction (LVEF), cardiac...
Abstract During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for complications has attracted much attention continues be actively explored. The endothelium lines all blood vessels is close cells, including adipocytes. been suggested act paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), modulator white phenotype. show that...
Abdominal aortic aneurysm (AAA) is a silent, progressive disease with high mortality and an increasing prevalence aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) cells porcine carotid artery (PCA) model early aneurysm. Human AAA-SMC presented secretory phenotype expressed elevated levels differentiation marker miR-145 (2.2-fold, p < 0.001)...
Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function poorly understood. To examine endothelial cell (EC) biology, we generated mice with catalytic inactivation one SHIP2 allele selectively ECs (ECSHIP2Δ/+). Hyperinsulinemic-euglycemic clamping studies revealed ECSHIP2Δ/+ was resistant to insulin-stimulated glucose uptake adipose tissue and skeletal...
Abstract Background Cardiovascular disease (CVD) is the main cause of death in people with abdominal aortic aneurysm (AAA). There little evidence that screening for AAA reduces all-cause or cardiovascular mortality. The aim study was to assess whether subjects a small medium (3·0–5·4 cm), without previous history clinical CVD, had raised levels CVD biomarkers increased total Methods This prospective included and controls, all CVD. (high-sensitivity C-reactive protein, hs-CRP; heart-type...
Insulin and insulin-like growth factor-1 stimulate specific responses in arteries, which may be disrupted by diet-induced obesity. We examined (1) temporal effects of high-fat diet compared to low-fat mice on insulin receptor, receptor/insulin-like receptor hybrid expression insulin/insulin-like factor-1-mediated Akt phosphorylation aorta; (2) vascular tone resistance arteries. Medium-term (5 weeks) decreased increased (~30%) only. After long-term (16 diet, was reduced ~30%, a further ~40%...
Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of from the insulin-resistant endothelium is Nox2 isoform NADPH oxidase. Here we examine therapeutic potential inhibition on in saphenous vein ECs (SVECs) patients with advanced atherosclerosis type 2 diabetes vascular function, damage, lipid deposition apolipoprotein E-deficient (ApoE-/-) mice EC-specific insulin (ESMIRO). To effect genetic Nox2, ESMIRO...
Abstract We have previously reported that overexpression of human insulin-like growth factor binding protein (IGFBP)-1 in mice leads to vascular insulin sensitization, increased nitric oxide bioavailability, reduced atherosclerosis, and enhanced repair, the setting obesity improves glucose tolerance. Human studies suggest low levels IGFBP-1 are permissive for development diabetes cardiovascular disease. Here we seek determine whether loss plays a causal role predisposition cardiometabolic...
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production superoxide and a simultaneous reduction in the availability vasoprotective signaling radical NO. We recently demonstrated preclinical models that simultaneously causes resistance IGF-1 (insulin-like growth factor-1)–mediated glucose lowering NO release. Objective: To examine effect specifically ECs vivo. Methods Results: generated mice expressing mIGF-1Rs (mouse...
Abdominal aortic aneurysm (AAA) growth is a complex process that incompletely understood. Significant heterogeneity in trajectories between patients has led to difficulties accurately modeling across cohorts of patients. We set out compare four models commonly used the literature and confirm which best fits patient data our AAA cohort.Patients with were included study if they had two or more abdominal ultrasound scans greater than 3 months apart. Patients censored from analysis once their...
Report2 May 2021Open Access Source DataTransparent process Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity Natalie J Haywood orcid.org/0000-0002-8762-7257 Faculty of Medicine and Health, Leeds Institute Cardiovascular Metabolic Medicine, University Leeds, UK Search for more papers by this author Cheukyau Luk Katherine I Bridge Michael Drozd Natallia Makava Anna Skromna Amanda Maccannell Claire H Ozber Nele Warmke Chloe G Wilkinson Nicole T...
High fat diet (HFD)-induced obesity leads to perturbation in the storage function of white adipose tissue (WAT) resulting deposition lipids tissues ill-equipped deal with this challenge. The role insulin like growth factor-1 (IGF-1) systemic and organ-specific responses HFD is unclear. Using cixutumumab, a monoclonal antibody that internalizes degrades cell surface IGF-1 receptors (IGF-1 R), leaving receptor expression unchanged we aimed establish R response HFD. Mice treated cixutumumab fed...
Introduction Abdominal aortic aneurysms (AAA) are characterized by a progressive dilatation of the abdominal aorta, and associated with high risk rupture once exceeds 55 mm in diameter. A large proportion AAA develops an intraluminal thrombus, which contributes to hypoxia, inflammation tissue degradation. We have previously shown that patients produce clots altered structure is more resistant fibrinolysis. The aim this study was investigate genetic polymorphisms FXIII fibrinogen identify how...
Objective Thrombin-activatable fibrinolysis inhibitor (TAFI) reduces the breakdown of fibrin clots through its action as an indirect plasmin. Studies in TAFI-deficient mice have implicated a potential role for TAFI Abdominal Aortic Aneurysm (AAA) disease. The inhibition on AAA formation adult ApoE-/- is unknown. aim this paper was to investigate effects development and progression. Methods Using Angiotensin II model AAA, male were infused with 750ng/kg/min or without monoclonal antibody...