A5023563741- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Biomimetic flight and propulsion mechanisms
- Advanced Frequency and Time Standards
- Cold Atom Physics and Bose-Einstein Condensates
- Atomic and Subatomic Physics Research
- Advanced Sensor and Energy Harvesting Materials
- Underwater Vehicles and Communication Systems
- Single-cell and spatial transcriptomics
- Molecular Sensors and Ion Detection
- Extracellular vesicles in disease
- Antenna Design and Optimization
- Antenna Design and Analysis
- Nanoplatforms for cancer theranostics
- Dyeing and Modifying Textile Fibers
- Micro and Nano Robotics
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- Scientific Measurement and Uncertainty Evaluation
- Organic Light-Emitting Diodes Research
- Atmospheric chemistry and aerosols
- Aerospace Engineering and Energy Systems
- Immune cells in cancer
- Polydiacetylene-based materials and applications
Soochow University
2020-2025
Cornell University
2022-2025
Saint Meinrad Seminary and School of Theology
2025
Allen Institute for Immunology
2025
Monash Medical Centre
2025
Tsinghua University
2021-2024
Harbin Engineering University
2024
Harbin Institute of Technology
2024
Sichuan University
2024
Jinzhou Medical University
2024
We give an overview of the work done with Laboratoire National de M\'etrologie et d'Essais-Syst\`emes R\'ef\'erence Temps-Espace (LNE-SYRTE) fountain ensemble during last five years. After a description clock ensemble, comprising three fountains, FO1, FO2, and FOM, newest developments, we review recent studies several systematic frequency shifts. This includes distributed cavity phase shift, which evaluate for FO1 FOM applying techniques our on FO2. also report calculations microwave lensing...
Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various applications. While the current method relies on drainage of nanoparticles to lymph nodes by intramuscular (IM) or subcutaneous (SC) injections, efficient carrier SLOs-targeting systemic administration (IV) is highly desirable but yet be available. In this study, we developed using phosphatidylserine (PS), a well-known signaling molecule that promotes endocytic activity phagocytes and cellular entry...
Abstract Although therapies of cancer are advancing, it remains challenging for therapeutics to reach the sites metastasis, which accounts majority associated death. In this study, we have developed a strategy that guides an anti-programmed cell death-ligand 1 (aPDL1) antibody accumulate in metastatic lesions promote anti-tumour immune responses. Briefly, combination Vadimezan disrupts tumour blood vessels metastases and facilitates recruitment activation adoptively transferred...
Abstract Neural networks such as variational autoencoders (VAE) perform dimensionality reduction for the visualization and analysis of genomic data, but are limited in their interpretability: it is unknown which data features represented by each embedding dimension. We present siVAE, a VAE that interpretable design, thereby enhancing downstream tasks. Through interpretation, siVAE also identifies gene modules hubs without explicit network inference. use to identify whose connectivity...
One of the greenest and promising ways to solve problem freshwater crisis is surface solar steam generation from seawater. A great number photothermal materials with multi-component multi-layered delicate yet complex structures often suffer either low evaporation rate or high energy loss. Here, this work presents a single component foam evaporator up 4.32 kg m
We evaluate the distributed cavity phase and microwave lensing frequency shifts, which were two largest sources of uncertainty for NPL-CsF2 cesium fountain clock. report measurements that confirm a detailed theoretical model fields shifts clock they produce. The significantly reduce to $1.1 \times 10^{-16}$. derive shift cylindrical with circular apertures. An analytic result reasonable approximations is given, in addition full calculation indicates $6.2 10^{-17}$. models we report, along...
Abstract Chimeric antigen receptor (CAR) T cells exhibit promising results for cancer immunotherapy. However, the clinical success is still restricted to certain types of blood cancers, while in solid tumors activity modest and potential toxicities remain a concern. There are various barriers that prevent CAR from combating tumors. Therefore, distinct strategies have been explored augment cell proliferative capacity, persistence, effector function. Altering tumor microenvironment, particular...
Solar-driven desalination systems have been recognized as an effective technology to address the water crisis. Recently, evaporators prepared based on advanced manufacturing technologies emerged a promising tool in enhancing ocean energy utilization. In this review, we discussed thermal conversion, flow, salt deposition mechanisms, and design strategies for solar-driven systems, explored how improve performance use efficiency of through technologies. future perspectives, determined...
We demonstrate agreement between measurements and ab initio calculations of the frequency shifts caused by distributed cavity phase variations in microwave a primary atomic fountain clock. Experimental verification finite element models cavities gives first quantitative evaluation this leading uncertainty allows it to be reduced $\ensuremath{\delta}\ensuremath{\nu}/\ensuremath{\nu}=\ifmmode\pm\else\textpm\fi{}8.4\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}17}$. Applying these...
The development of multifunctional photosensitizers (PSs) with aggregation-induced emission (AIE) properties plays a critical role in promoting the progress photodynamic therapy (PDT). In this work, PS (named DSABBT NPs) AIE activity has been designed and prepared to carry out ultrafast staining, excellent two-photon bioimaging, high-efficiency image-guided PDT. Simply, characteristic was synthesized by one-step Schiff reaction 4-(diethylamino)-salicylaldehyde (DSA)...
Achieving therapeutic efficacy in protein replacement therapies requires sustaining pharmacokinetic (PK) profiles, while maintaining the bioactivity of circulating proteins. This is often achieved via PEGylation protein-based therapies, but it remains challenging for proteins produced vivo mRNA-based due to lack a suitable post-translational modification method. To address this issue, we integrated genetically encoded zwitterionic polypeptide, EKP, into mRNA constructs enhance PK properties...
We perform 3D finite element calculations of the fields in microwave cavities and analyze distributed cavity phase errors atomic clocks that they produce. The cylindrical are treated as an azimuthal Fourier series. Each lowest components produces clock with unique characteristics must be assessed to establish a clock's accuracy. describe how evaluate them. prove sharp structures do not produce large frequency errors, even at moderately high powers, provided density varies slowly. model...
Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to the polarization of TAMs suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded lipid droplets be released at site upon cell-triggered lipolysis. Locally administered drug-loaded increased in both primary distant tumors suppressed growth melanoma model. Furthermore, improved...
Although recombinant adeno-associated viruses (AAVs) are considered low immunogenic and safe for gene delivery, the immunogenicity of capsids still represents a major obstacle to readministration AAV vectors. Here, we design an immunosuppressive zwitterionic phosphoserine (PS)-containing polypeptide induce AAV-specific immune tolerance eradicate immunological response. AAVs modified with PS maintain their transduction activity tissue tropism but suppress induction antibodies. In hemophilia A...
This work utilizes aspartic acid as both an acidulant and a chelant, effectively controlling the crystallization rate of Prussian blue, reducing its usage, enhancing electrochemical performance.
Spatially resolved transcriptomics technologies have advanced our understanding of cellular characteristics within tissue contexts. However, current analytical tools often treat cell-type inference and neighborhood identification as separate hard clustering processes, limiting comparability across scales samples. SPARROW addresses these challenges by jointly learning latent embeddings soft clusterings cell types organization. It outperformed state-of-the-art methods in microenvironment zone...
<title>Abstract</title> Dendritic cells (DCs) can process patient-derived antigens to generate extracellular vesicles (DEVs) vaccines, which be personalized and rapidly adapted the evolving antigenic profile in chronic diseases. These DEVs present stimulate T cell responses, but their clinical efficacy is limited by poorly understood mechanisms. This study reveals how DCs incorporate ancient viral genes produce endogenous virus-like (VLVs) that enable long-range communication. Overexpressing...