A5054709660- Advanced Measurement and Metrology Techniques
- Neuroscience and Neural Engineering
- Mast cells and histamine
- Optical measurement and interference techniques
- Scientific Measurement and Uncertainty Evaluation
- Platelet Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- CO2 Sequestration and Geologic Interactions
- Wireless Communication Networks Research
- Advanced Wireless Communication Techniques
- Neural dynamics and brain function
- Enhanced Oil Recovery Techniques
- Ion channel regulation and function
- Analytical Chemistry and Sensors
- Cooperative Communication and Network Coding
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Context-Aware Activity Recognition Systems
- Advanced Sensor Technologies Research
- Advanced Memory and Neural Computing
- Glaucoma and retinal disorders
- Advanced Surface Polishing Techniques
- Polyamine Metabolism and Applications
Naval Postgraduate School
2024-2025
University of Virginia
2023-2024
Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer
2022
Cleveland Clinic
2020-2022
Cleveland Eye Clinic
2020-2022
Physikalisch-Technische Bundesanstalt
2003-2021
The University of Texas at Austin
2020
Institut für Solartechnologien (Germany)
2018
Gilead Sciences (United States)
2014-2017
Saarland University
2012-2017
In hippocampal and other cortical neurons, action potentials are followed by afterhyperpolarizations (AHPs) generated the activation of small-conductance Ca 2+ -activated K + channels (SK channels). By shaping neuronal firing pattern, these AHPs contribute to regulation excitability encoding function neurons. Here we report that CA1 pyramidal neurons express an AHP current is suppressed apamin involved in control repetitive firing. This presents distinct kinetic pharmacological features, it...
Schizophrenic patients are thought to have an impaired ability process sensory information. This deficit leads disrupted auditory gating measured electrophysiologically as a reduced suppression of the second paired auditoryevoked responses (P50) and is proposed be associated with decreased function and/or expression homomeric α7 nicotinic acetylcholine receptor (nAChR). Here, we provide evidence that <i>N</i>-[(3<i>R</i>)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride...
Self-motion signals are sufficient for animal navigation (“path integration”) and updating hippocampal location-specific firing. The contributions of ambulatory, vestibular, optic self-motion to CA1 unit activity EEG were studied while rats either walked or drove a car between locations on circular track (referred as WALK CAR, respectively) experienced pseudomotion, in which the was stationary environment rotated (WORLD). Fewer pyramidal cells expressed place fields during CAR those that did...
Mesodermal development is a multistep process in which cells become increasingly specialized to form specific tissue types. In Drosophila and mammals, proper segregation patterning of the mesoderm involves bHLH factor Twist. We investigated activity Twist-related factor, CeTwist, during Caenorhabditis elegans development. Embryonic C. derives from number distinct founder that are specified early lineages; contrast, single blast cell (M) responsible for all nongonadal formation postembryonic...
Nucleus accumbens (NAc) inactivation increases food intake, indicating that NAc neurons exert ongoing inhibition of feeding. We previously described a subpopulation pause during sucrose licking and proposed the permits consumption. tested this hypothesis by first recording consumption, then electrically stimulating through same electrodes. A large proportion shell core were inhibited local electrical stimulation abruptly interrupted licking. Effective sites more anterior than ineffective in...
Experimental studies of both drainage and imbibition displacements are needed to improve our fundamental understanding multi-phase flow trapping in CO2-brine systems effectively take advantage the large storage capacity saline aquifers. Very few relative permeability measurements have been made even fewer with situ saturation measurements. Two new sets steady state two different rock samples, over a range injection rates. These show that brine displacement efficiency is strongly affected by...
Summary Saline-aquifer storage of carbon dioxide (CO2) has become recognized as an important strategy for climate-change mitigation. Saline aquifers have very large estimated capacities, are distributed broadly across the globe, and potential geologic-scale retention times. Many these sites not well characterized, it is critical to conduct detailed experiments analysis understand how features such heterogeneity can influence theoretical capacity, spatial extent plume migration, secondary...
Negative features in microdevices find a wide range of applications. The process 3D printing has revolutionized their fabrication due to the combination good resolution and integration capability. Herein, we report on systematic study effects materials print directions microfluidic channels as negative under PolyJet technology. Specifically, Statasys Objet500 printer was used for this study. We printed two sets chips (n=10 each), each which contains channel pairs high-contrast reference...
At the Physikalisch-Technische Bundesanstalt, autocollimators are calibrated with aid of WMT 220 angle comparator to ensure their direct traceability SI unit plane angle, radian (rad). It is shown that high-resolution electronic can thus be an uncertainty 0.007 arcsec (k = 2) in reproducible measurement steps down 0.005 arcsec. Calibrations very small close autocollimators' resolution inform about possible short-period deviations and resulting aliasing effects measurements autocollimators.
A new highly precise angle measuring table has been developed for the Physikalisch-Technische Bundesanstalt, which is to be used as a comparator calibrate standards. First results of determination comparator's errors measurement obtained by two calibration methods are reported. Considering obtained, it expected that desired uncertainty can achieved.
At the Physikalisch-Technische Bundesanstalt (PTB), a self-calibration method for fast and precise in situ calibration of angle encoders without recourse to external reference standards has been developed. It relies on suitable geometric arrangement multiple reading heads which read out radial grating encoder at different angular positions. Fourier-based algorithms are used analyse measurement differences pairs recover graduation error grating. A comprehensive overview, both theoretical...
Artificial muscles underlie exciting, novel technologies that have many wide-reaching applications: exoskeleton actuation, walker robots, prosthetics and stealthy underwater propulsion. Actuating these via electrostatic forces promises excellent energy efficiency output force density a high strength-to-weight ratio. Building through 3D-printed conductive microfluidics fast mass production at low cost. A microfluidic double-helix weave as potential solution for the architectural design of...
Pancreatic α-cells express voltage-gated Na(+) channels (NaChs), which support the generation of electrical activity leading to an increase in intracellular calcium, and cause exocytosis glucagon. Ranolazine, a NaCh blocker, is approved for treatment angina. In addition its antianginal effects, ranolazine has been shown reduce HbA1c levels patients with type 2 diabetes mellitus coronary artery disease; however, mechanism behind antidiabetic effect unclear. We tested hypothesis that exerts...