A5001112515- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Childhood Cancer Survivors' Quality of Life
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- Neurological Complications and Syndromes
- Multiple and Secondary Primary Cancers
- Cytomegalovirus and herpesvirus research
- Sarcoma Diagnosis and Treatment
- Uterine Myomas and Treatments
- Genetic Syndromes and Imprinting
- Galectins and Cancer Biology
- CNS Lymphoma Diagnosis and Treatment
St. Eugenio Hospital
2024-2025
ASL Roma
2024-2025
Azienda Ospedaliera Pugliese Ciaccio
2020-2023
Université Laval
2022
Institute for Biomedical and Pharmaceutical Research
2022
University of Bonn
2022
The University of Texas MD Anderson Cancer Center
2022
UCLouvain
2022
Sapienza University of Rome
2008-2019
Policlinico Umberto I
2016-2017
RNA-seq is a promising technology to re-sequence protein coding genes for the identification of single nucleotide variants (SNV), while simultaneously obtaining information on structural variations and gene expression perturbations. We asked whether suitable detection driver mutations in T-cell acute lymphoblastic leukemia (T-ALL). These leukemias are caused by combination fusions, over-expression transcription factors cooperative point oncogenes tumor suppressor genes. analyzed 31 T-ALL...
Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that commonly driven by recurrent gene rearrangements. In conventional low‐grade ESS, JAZF1‐SUZ12 , PHF1‐JAZF1 EPC1‐PHF1 and MEAF6‐PHF1 recently described ZC3H7 ‐ BCOR chimeric fusions have been reported in > 50% cases. Conversely, oncogenic t(10;17)(q22;p13) translocation yields YWHAE‐FAM22A/B proteins associated with histologically high‐grade clinically more aggressive ESS. Integrating...
To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate prognostic role additional genomic lesions, we analyzed copy number aberrations using Cytoscan HD Array in 116 newly diagnosed adult patients with enrolled four different GIMEMA protocols, all based on a chemotherapy-free induction strategy. This analysis showed that carry an average 7.8 lesions/case, deletions outnumbering gains (88% versus 12%). The most common were...
Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the stem cell compartment drive disease pathogenesis. Recent advancements genomic profiling have provided valuable insights into biological underpinnings MDSs and expanded therapeutic options, particularly for specific molecularly defined subgroups. This review highlights diagnostic principles, classification updates, prognostic...
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs recurrently mutated cancer genes are becoming available for many types. Increasing access to sequencing technology, including bench-top sequencers, provide opportunity re-sequence a limited set across patient cohort with processing time. Here, we re-sequenced in T-cell acute lymphoblastic leukemia (T-ALL) using Nimblegen sequence capture coupled Roche/454 technology. First, investigated how maximal sensitivity...
Summary BCR / ABL 1 ‐like acute lymphoblastic leukaemia ( ALL ) is a subgroup of B‐lineage that occurs within cases without recurrent molecular rearrangements. Gene expression profiling GEP can identify these but it expensive and not widely available. Using , we identified 10 genes specifically overexpressed by used their values – assessed quantitative real time‐polymerase chain reaction (Q‐ RT ‐ PCR in 26 non‐ to build statistical “ predictor”, for the identification cases. By screening 142...
Despite therapeutic improvements, a sizable number of patients with T-cell acute lymphoblastic leukemia still have poor outcome. To unravel the genomic background associated refractoriness, we evaluated transcriptome 19 cases refractory/early relapsed (discovery cohort) by performing RNA-sequencing on diagnostic material. The incidence and prognostic impact most frequently mutated pathways were validated Sanger sequencing DNA from samples an independent cohort 49 (validation cohort),...
This report discusses a rare case involving patient with high-risk (HR) Del(5q) myelodysplastic syndrome (MDS) who achieved long-term response to lenalidomide after having received six cycles of azacytidine. The latter treatment led the clearance blast cells from bone marrow (BM). As per current clinical practice, patients HR MDS receive azacytidine continuously until disease progresses or occurrence unmanageable side effects. However, in this case, decided interrupt hypomethylation therapy....
Acute lymphoblastic leukemia (ALL) remains an important cause of morbidity in children and adults. In this article, we highlight advances the genetics therapy three key subtypes ALL: T-cell ALL, BCR-ABL1 (Philadelphia [Ph] chromosone–positive), Ph-like ALL. T-ALL is aggressive disease that accounts for about 15% 25% ALL among pediatric adult cohorts, respectively, exhibits a multistep nature cancer initiation progression. The integration cytogenetics, molecular biology, immunophenotype...
// Monica Messina 1,* , Sabina Chiaretti Jiguang Wang 2,* Anna Lucia Fedullo 1 Nadia Peragine Valentina Gianfelici Alfonso Piciocchi 3 Fulvia Brugnoletti Filomena Di Giacomo 4 Simona Pauselli Antony B. Holmes 5 Maria Cristina Puzzolo Giulia Ceglie Valerio Apicella Marco Mancini Geertruy te Kronnie 6 Testi Antonella Vitale Vignetti Guarini Raul Rabadan 2 and Robin Foà Hematology, Department of Cellular Biotechnologies Sapienza University, Rome, Italy Systems Biology, Biomedical...
Antibody response following SARS-CoV2 vaccination is somewhat defective in chronic lymphocytic leukemia (CLL). Moreover, the correlation between serologic and status of cellular immunity has been poorly studied.This study was undertaken to assess humoral immune responses BNT162b2 messenger RNA (mRNA) COVID-19 CLL.The presence spike antibodies assessed at a median time 14 days from second vaccine dose 70 CLL followed-up single institution.The antibody rate (RR) patients 58.5%, compared 100%...