A5103265052- Nitric Oxide and Endothelin Effects
- Retinal Diseases and Treatments
- Multiple Sclerosis Research Studies
- Advanced Glycation End Products research
- Marine Biology and Ecology Research
- Plant and animal studies
- Subterranean biodiversity and taxonomy
- Retinal Development and Disorders
- Lepidoptera: Biology and Taxonomy
- Plant Pathogens and Fungal Diseases
- Insect and Arachnid Ecology and Behavior
- Molecular Biology Techniques and Applications
- Glaucoma and retinal disorders
- Animal Behavior and Reproduction
- Genetics, Aging, and Longevity in Model Organisms
- Neurological Disorders and Treatments
- Protist diversity and phylogeny
- Neurobiology and Insect Physiology Research
- Lichen and fungal ecology
- Parasitic Infections and Diagnostics
- Genomics and Phylogenetic Studies
- Ecology and Vegetation Dynamics Studies
- Insect and Pesticide Research
- Species Distribution and Climate Change
- Circadian rhythm and melatonin
Evelina London Children's Healthcare
2024
University of Surrey
2006-2024
University of Florida
1998-2023
Florida Museum of Natural History
2020-2023
University of California, Santa Barbara
2014-2022
Illumina (United States)
2021
Louisiana State University Health Sciences Center Shreveport
2021
Louisiana State University
2021
Texas A&M University
2005-2018
Imaging Center
2005-2018
Butterflies are a diverse and charismatic insect group that thought to have evolved with plants dispersed throughout the world in response key geological events. However, these hypotheses not been extensively tested because comprehensive phylogenetic framework datasets for butterfly larval hosts global distributions lacking. We sequenced 391 genes from nearly 2,300 species, sampled 90 countries 28 specimen collections, reconstruct new phylogenomic tree of butterflies representing 92% all...
In this study, we demonstrate, for the first time, localization of insulin-like growth factor I (IGF-I) in de novo and restenotic human coronary atherectomy plaques by using immunocytochemical techniques. Smooth muscle cells (SMCs) exhibiting synthetic phenotype contained a statistically significant higher concentration IGF-I than SMCs contractile or from normal arteries. addition, provide data to suggest that long-acting somatostatin analogues octreotide angiopeptin inhibit IGF-I- basic...
One of the great mysteries evolutionary biology is why closely related lineages accumulate species at different rates. Theory predicts that populations undergoing strong sexual selection will more quickly differentiate because increased potential for genetic isolation [1Verrell P.A. Illegitimate exploitation signalling systems and origin species.Ethol. Ecol. Evol. 1991; 3: 273-283Crossref Scopus (26) Google Scholar, 2West-Eberhard M.J. Sexual selection, social competition, speciation.Q. Rev....
Opsins, combined with a chromophore, are the primary light-sensing molecules in animals and crucial for color vision. Throughout animal evolution, duplications losses of opsin proteins common, but it is unclear what driving these gains losses. Light availability implicated, dim environments often associated low diversity loss. Correlations between high bright environments, however, tenuous. To test if increased light diversification, we examined diel niche identified opsins using...
This morphological study demonstrates a role for endothelial cells in generating reactive oxygen species early stages of retinopathy the BBZ/Wor rat, an obese, noninsulin dependent model diabetes. Hyperglycemia induced pseudohypoxia results imbalance cytosolic NADH/NAD+. In oxygen-rich environment retina, NADH oxidase generates superoxide radical which is dismutated to hydrogen peroxide. Localization peroxide by cerium enzyme activity cytochemical localization technique shows statistically...
To determine whether hematopoietic stem and progenitor cells (HSCs/HPCs) can home to regenerate the retinal pigment epithelium (RPE) after induced injury.Enriched HSCs/HPCs from green fluorescent protein (gfp) transgenic mice were transplanted into irradiated recipient track bone marrow-derived cells. Physical damage was by breaching Bruch's membrane inducing vascular endothelial growth factor A (VEGFa) expression promote neovascularization. RPE also sodium iodate injection (40 mg/kg)...
Atm1p is an ABC transporter localized in the mitochondrial inner membrane; it functions to export unknown species into cytosol and involved cellular iron metabolism. Depletion or deletion of causes Fe accumulation mitochondria a defect cytosolic Fe/S cluster assembly but reportedly not assembly. In this study nature accumulated was examined using Mössbauer spectroscopy, EPR, electronic absorption X-ray electron microscopy. The that aerobically grown cells form iron(III) phosphate...
Abstract The spectra of fiber and axon diameter, myelin sheath thickness, density, g ratio the optic nerve were analyzed for strain‐13 guinea pig, an animal extensively utilized in investigation experimental disorders demyelination. Our detailed analytical study normal pig provides basis comparison to disease states morphology other species. As rat, mouse, chipmunk, diameters unimodal, but dissimilar trimodal cat primate. predominance medium‐sized fibers (0.80–2.00 μm), common most species,...
Yah1p, an [Fe2S2]-containing ferredoxin located in the matrix of Saccharomyces cerevisiae mitochondria, functions synthesis Fe/S clusters and heme a prosthetic groups. EPR, Mössbauer spectroscopy, electron microscopy were used to characterize Fe that accumulates Yah1p-depleted isolated intact mitochondria. Gal-YAH1 cells grown standard rich media (YPD YPGal) under O2 or argon atmospheres. Mitochondria anaerobically, then prepared as-isolated redox state, dithionite-treated O2-treated state....
Two species of the genus Ptilohyale were collected from shallow coastal waters Korea. One is identified as a new species: brevicrus sp. nov. The morphology gnathopod 2, pereopods, uropods and mandible are major characteristics which differentiate its congeners. remaining species, P. barbicornis (Hiwatari & Kajihara, 1981) recorded for first time Both fully described illustrated. A key to family Hyalidae Korea also provided.
Abstract Background The availability of thousands genomes has enabled new advancements in biology. However, many have not been investigated for their quality. Here we examine quality trends a taxonomically diverse and well-known group, butterflies (Papilionoidea), provide draft, de novo assemblies all available butterfly genomes. Owing to massive genome sequencing investment taxonomic curation, this is an excellent group explore Findings We 822 interpret terms completeness continuity....
Synaptonemal complexes have been demonstrated previously in the young sporonts of certain microsporidia. Now, for first time any microsporidium, meiosis is substantiated through observation chromosomes. Specifically, meiotic configurations were observed diplokaryotic an undescribed species Amblyospora Hazard and Oldacre mosquito Culex salinarius Coquillett. A haploid chromosome number 7 was determined. Also, electron micrographs these those Parathelohania Codreanu, a closely related genus...
In mammals, Bone Morphogenetic Protein (BMP) pathway signaling is important for the growth and homeostasis of extracellular matrix, including basement membrane remodeling, scarring, bone growth. A conserved BMP member in Caenorhabditis elegans, DBL-1, regulates body length a dose-sensitive manner. Loss DBL-1 also results increased anesthetic sensitivity. However, physiological basis these pleiotropic phenotypes largely unknown. We created over-expressing strain show that sensitivity to...
We have employed FITC−albumin as the protein template molecule in an aqueous phase molecular imprinted polymer (HydroMIP) strategy. For first time, use of a fluorescently labeled is reported, with subsequent characterization smart material to show that HydroMIP possesses significant memory comparison nonimprinted control (HydroNIP). The imaging using confocal microscopy described, situ removal displayed terms observed changes fluorescence polymer, both before and after elution (using 10%...
The ability to control the differentiation of adult hematopoietic stem cells (HSCs) would promote development new cell-based therapies treat multiple degenerative diseases. Systemic injection NaIO3 was used ablate retinal pigment epithelial (RPE) layer in C57Bl6 mice and initiate neural degeneration. HSCs infected ex vivo with lentiviral vector expressing RPE-specific gene RPE65 restored a functional RPE layer, typical phenotype including coexpression another marker, CRALBP, photoreceptor...
Dicyemids and orthonectids were traditionally classified in a group called Mesozoa, but their placement single clade has been contested position(s) within Metazoa is uncertain. Here, we assembled comprehensive matrix of Lophotrochozoa (Metazoa) investigated the position Dicyemida (= Rhombozoa) Orthonectida, employing multiple phylogenomic approaches. We sequenced seven new transcriptomes one draft genome from dicyemids ( Dicyema , Dicyemennea ) two Rhopalura ). Using these published data,...