A5038041091- Antibiotic Resistance in Bacteria
- Travel-related health issues
- Burkholderia infections and melioidosis
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric health and respiratory diseases
- Vibrio bacteria research studies
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- Salmonella and Campylobacter epidemiology
- Bacterial biofilms and quorum sensing
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- HIV/AIDS drug development and treatment
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Gut microbiota and health
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Ocular Infections and Treatments
- Escherichia coli research studies
- School Health and Nursing Education
Universiti Sains Malaysia
2016-2025
Hospital Universiti Sains Malaysia
2014-2025
University Kebangsaan Malaysia Medical Centre
2021
Universiti Malaysia Kelantan
2019
Monash University
2012-2013
The University of Sydney
2009
The dry antibiotic development pipeline coupled with the emergence of multidrug resistant Gram-negative 'superbugs' has driven revival polymyxin lipopeptide antibiotics. Polymyxin resistance implies a total lack antibiotics for treatment life-threatening infections. molecular imaging probes that possess native polymyxin-like antibacterial activity is barrier to understanding mechanisms and new generation lipopeptides. Here we report regioselective modification B core scaffold at N-terminus...
Respiratory tract infection (RTI) is a major public health challenge during the Muslim pilgrimage to Makkah. This study aims evaluate knowledge, attitude, and practice of Malaysian Hajj Umrah pilgrims towards prevention RTIs in 2018 determine correlations among three domains. A cross-sectional was conducted 225 pilgrims. Knowledge, (KAP) RTI assessed by using validated self-administered questionnaire attending weekly orientation course organized private Hajj/Umrah companies. Out...
Hajj pilgrimage faces numerous challenges including a high prevalence of respiratory tract infection as well its prevention strategies. The aim this study was to develop and validate questionnaire evaluate knowledge, attitude practice (KAP) towards infections (RTIs) among Malaysian pilgrims.This conducted Umrah pilgrims in Malaysia from Kuala Lumpur Kelantan. then underwent series validation process that included content, face validity exploratory part. Item response theory (IRT) analysis...
Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- therapy against MDR K. emergence of resistance. A one-compartment in vitro pharmacokinetic/pharmacodynamic model was employed over a 72-h period two inocula (∼10(6) ∼10(8) CFU/ml); colistin-heteroresistant reference strain (ATCC 13883) three clinical isolates (colistin-susceptible FADDI-KP032 [doripenem resistant], FADDI-KP033,...
Respiratory symptoms including cough, runny nose, sore throat, and fever are the most common clinical manifestations faced by hajj pilgrims in Mecca. The aim of study was to determine prevalence respiratory among Malaysian effect a few protective measures taken reduce symptoms.A cross-sectional conducted distributing survey forms at transit center before flying back Malaysia. recruitment respondents on voluntary basis.A total 387 were available for analysis. mean age 50.4 +/- 11.0 years....
This study examines the interaction of polymyxin B and colistin with surface outer membrane components a susceptible resistant strain Klebsiella pneumoniae. The between polymyxins bacterial isolated LPS from paired wild type polymyxin-resistant strains K. pneumoniae were examined N-phenyl-1-naphthylamine (NPN) uptake, fluorometric binding thermal shift assays, lysozyme deoxycholate sensitivity by 1 H NMR. displayed reduced affinity for in comparison LPS. NPN permeability was greater compared...
With increasing prevalence and spread of multidrug resistant Gram-negative infections, parenteral polymyxins resurged in clinical practice. The primary aim the study was to determine predictors treatment failure in-hospital mortality among critically ill patients treated with polymyxin B.Demographic data, underlying diseases, procedures details on B therapy were retrospectively analyzed a cohort 84 who received intravenous an intensive care unit from 2010 2014.Polymyxin used treat bacteremia...
Abstract Background: Increasing trend and spread of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) in clinical settings is a great challenge managing patients with infections caused by this pathogen. Objective: To determine the risk factors outcomes MDR-PA acquisition northeastern state Malaysia. In addition, study also reported on susceptibility pattern common resistant genes among MDR-PA. Materials Methods: isolates obtained between March 2021 February 2022 from all four major...
AIMS: In Malaysia, Shigella spp. is the third most common bacterial agent responsible for childhood diarrhoea. This study was conducted to determine prevalence and antimicrobial susceptibility patterns of isolated from patients admitted Hospital Universiti Sains Malaysia January 2001 December 2009. SUBJECTS AND METHODS: A hospital-based retrospective used. Stool samples were cultured using a standard culture method. isolates identified by biochemical serological methods, pattern evaluated...
We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day 9.5 log CFU/capsule) in improving symptoms vaginal irritation, discharge and burning pregnant women with candidiasis upon administration for 8 weeks, accompanied by improved emotional social quality life parameters. Thus, present study aimed to analyse microbiota inflammatory changes hope better understand clinical as observed previously. Patients group showed decreased abundance Candida...
We report the first case of a human Burkholderia tropica infection. The patient was premature neonate who had necrotizing enterocolitis with bowel perforation requiring surgical intervention. stoma care and difficulties in feeding were chronic problem. At age almost 4 months he developed septicemia due to B. tropica. Three consecutive blood cultures grew this organism. organism cleared from after course imipenem resolution post-operative ileus. Our suggests that environmental plant pathogens...
The aim of this study was to investigate the effects lactobacilli strains in preventing recurrences vaginal candidiasis (VC) 78 pregnant women with VC (lactobacilli, n = 39; placebo, 39) and potential benefits on quality life.The putative probiotic (SynForU-HerCare; two capsules/day 9·5 log CFU per capsule) or placebo administered for 8-weeks a randomized, double-blind, placebo-controlled study. Subjects were assessed gut health conditions at baseline, week-4 week-8 via questionnaires....
In a recent summary of integrase sequences, primary inhibitor mutations were rare. review inhibitor-naïve Australian HIV-1 not identified, although the accessory mutation G140S was detected. A link with previous antiretroviral therapy, intra-subtype B divergence across gene and transmission polymorphisms also noted. Based on these findings, we would recommend ongoing surveillance mutations, region sequencing for patients prior to commencement inhibitors.