A5066688910- Biochemical and Molecular Research
- Drug Solubulity and Delivery Systems
- Surfactants and Colloidal Systems
- Analytical Chemistry and Chromatography
- HIV/AIDS drug development and treatment
- Lanthanide and Transition Metal Complexes
- Advancements in Transdermal Drug Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Lipid Membrane Structure and Behavior
- Advanced NMR Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Protein Structure and Dynamics
- Microbial Natural Products and Biosynthesis
- Spectroscopy and Quantum Chemical Studies
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Crystallization and Solubility Studies
Monash University
2010-2024
Australian Regenerative Medicine Institute
2008-2024
The University of Melbourne
2000-2020
Parks Victoria
2017
Institute of Medicinal Plant Development
2012-2014
Biotechnology Institute
2009
Macquarie University
2000-2008
Wilmington University
1999-2004
Innovative Clinical Research
2004
Albert Einstein College of Medicine
2004
Abstract The permeability of human epidermis to many phenolic compounds can be related octanol/water partition coefficients. For a series having similar diffusion coefficients and showing an increase in lipophilic character, the maximum flux will obtained with less because solubility decreases more rapidly than coefficient increases. penetration some is concentration dependent, constant being observed below threshhold above which increases concentration. attributed ‘damage’ reduction its...
P. Molyneux, C. T. Rhodes and J. Swarbrick, Trans. Faraday Soc., 1965, 61, 1043 DOI: 10.1039/TF9656101043
The dry antibiotic development pipeline coupled with the emergence of multidrug resistant Gram-negative 'superbugs' has driven revival polymyxin lipopeptide antibiotics. Polymyxin resistance implies a total lack antibiotics for treatment life-threatening infections. molecular imaging probes that possess native polymyxin-like antibacterial activity is barrier to understanding mechanisms and new generation lipopeptides. Here we report regioselective modification B core scaffold at N-terminus...
Structural studies of proteins and protein-ligand complexes by nuclear magnetic resonance (NMR) spectroscopy can be greatly enhanced site-specific attachment lanthanide ions to create paramagnetic centers. In particular, pseudocontact shifts (PCS) generated lanthanides contain important unique long-range structure information. Here, we present a high-affinity binding tag that attached single cysteine residues proteins. The new has many advantageous features are not available in this...
The cysteine-rich secretory proteins (Crisp) are predominantly found in the mammalian male reproductive tract as well venom of reptiles. Crisps two domain with a structurally similar yet evolutionary diverse N-terminal and characteristic C-terminal domain, which we refer to Crisp domain. We presented NMR solution structure mouse Tpx-1, showed that it contains subdomains, one has fold ion channel regulators BgK ShK. Furthermore, have demonstrated for first time regulatory activity is...
Abstract The water vapour transmission properties of selected hydrophilic, lipophilic, and mixed hydrophilic-lipophilic polymer systems, cast as free films, have been examined a function time, film thickness, plasticiser concentration, formulation. An inverse linear relationship was established between the logarithm rate (Rwvt) thickness in presence various concentrations for three systems studied. lipophilic n-butyl methacrylate films were found to be less permeable moisture than either...
The voltage-gated potassium (Kv) 1.3 channel is widely regarded as a therapeutic target for immunomodulation in autoimmune diseases. ShK-186, selective inhibitor of Kv1.3 channels, ameliorates diseases rodent models, and human phase 1 trials this agent healthy volunteers have been completed. In study, we identified characterized large family Stichodactyla helianthus toxin (ShK)-related peptides parasitic worms. Based on phylogenetic analysis, 2 worm were selected study: AcK1, 51-residue...
Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from hitherto-unculturable soil bacterium, Eleftheria terrae, and recognized potent antibacterial agent against various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-resistant enterococci. The most distinctive...
Methods based on pulse electron paramagnetic resonance allow measurement of the electron-electron dipolar coupling between two spin labels. Here we compare most popular technique, Double Electron-Electron Resonance (DEER or PELDOR), with dead-time free 5-pulse Relaxation-Induced Dipolar Modulation Enhancement (RIDME) method for Gd(iii)-Gd(iii) distance measurements at W-band (94.9 GHz, ≈3.5 T) using Gd(iii) tags a small zero field splitting (ZFS). Such are important because their high EPR...
VPS29 is a key component of the cargo-binding core complex retromer, protein assembly with diverse roles in transport receptors within endosomal system. has fold related to metal-binding phosphatases and mediates interactions between retromer other regulatory proteins. In this study we examine functional mammalian VPS29, using X-ray crystallography NMR spectroscopy. We find that although can coordinate metal ions Mn2+ Zn2+ both putative active site at locations, affinity for metals low, lack...
All the way with IDA! Attachment of iminodiacetic acid (IDA) to a protein helix creates rigid lanthanide binding site that can be exploited for paramagnetic NMR spectroscopy (see picture). Pseudo-contact shifts (PCSs) larger than 8 ppm are achievable tag, and metal exchange is sufficiently fast enable signal assignment by 15Nz spectroscopy, eliminating need an initial model. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamics of micellization some zwitterionic N-alkyl betainesJames Swarbrick and J. DaruwalaCite this: Phys. Chem. 1969, 73, 8, 2627–2632Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://doi.org/10.1021/j100842a029Request reuse permissionsArticle Views125Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads...