A5089253159- Pesticide Residue Analysis and Safety
- Dye analysis and toxicity
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Toxicity and Pharmacological Properties
- Drug-Induced Hepatotoxicity and Protection
- Environmental Toxicology and Ecotoxicology
- Analytical Methods in Pharmaceuticals
- Carcinogens and Genotoxicity Assessment
- Mycotoxins in Agriculture and Food
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Fungal Plant Pathogen Control
- Coccidia and coccidiosis research
- Marine Toxins and Detection Methods
- Aquaculture disease management and microbiota
- Toxic Organic Pollutants Impact
- Pharmacological Effects and Assays
- Agricultural safety and regulations
- Inflammatory mediators and NSAID effects
- Botanical Research and Chemistry
- Pluripotent Stem Cells Research
- Redox biology and oxidative stress
- Parasitic Infections and Diagnostics
- Isotope Analysis in Ecology
- Metabolomics and Mass Spectrometry Studies
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2014-2025
Centre Hospitalier de Fougères
2009-2024
Abstract Many efforts have been made in the last 30 years to develop more relevant vitro models study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one most promising for liver toxicology, a switch 3D cultures that integrate both vivo architecture cell-cell interactions has occurred achieve even predictive models. Preliminary studies indicated suitable toxicity screening. Our aimed evaluate response spheroids exposed various compounds using single...
An approach is described to validate a fast and simple targeted screening method for antibiotic analysis in meat aquaculture products by LC-MS/MS. The strategy of validation was applied panel 75 antibiotics belonging different families, i.e., penicillins, cephalosporins, sulfonamides, macrolides, quinolones phenicols. samples were extracted once with acetonitrile, concentrated evaporation injected into the LC-MS/MS system. chosen based on Community Reference Laboratory (CRL) guidelines...
The new challenges in toxicology demand novel and innovative vitro approaches for deriving points of departure (PODs) determining the mode action (MOA) chemicals. Therefore, aim this original study was to couple studies with untargeted metabolomics model concentration-response extra- intracellular metabolome data on human HepaRG cells treated 48 h three pyrrolizidine alkaloids (PAs): heliotrine, retrorsine lasiocarpine. Modeling revealed that PAs induced various monotonic and, importantly,...
Henri, J., Maurice, R., Postollec, G., Dubreil‐Cheneau, E., Roudaut, B., Laurentie, M., Sanders, P. Comparison of the oral bioavailability and tissue disposition monensin salinomycin in chickens turkeys. J. Vet. Pharmacol. Therap. 35 , 73–81. The current study describes pharmacokinetic parameters two carboxylic polyether ionophores: turkeys chickens. These data can be used to understand predict occurrence undesirable residues coccidiostats edible tissues these animal species. Special...
PTX-2 is a marine biotoxin frequently found in shellfish that can lead to food intoxication humans. Information regarding metabolism scarce, and little known of its effect on xenobiotic-metabolizing enzymes (XME) or molecular pathways. The aim this study was consequently examine Phase I using rat human liver S9 fractions, also assess the capability PTX-2: (i) modulate gene expression panel (CYP450) II (UGT, SULT, NAT, GST) enzymes, as well III 0 (ABC SLCO) transporters hepatic HepaRG cell...
A qualitative and quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the sensitive exhaustive analysis of residues from triarylmethane dyes, triarylmethane-derivative phenothiazines, phenoxazines xanthenes in aquaculture samples. For a wider more robust detection dye misuse on farms, other residue markers were also included leuco forms brilliant green, crystal violet malachite green; one direct metabolite Victoria pure blue BO methylene three bile...