A5101537469- Mycotoxins in Agriculture and Food
- Veterinary medicine and infectious diseases
- Plant Toxicity and Pharmacological Properties
- Insect and Pesticide Research
- Carcinogens and Genotoxicity Assessment
- Wheat and Barley Genetics and Pathology
- Fungal Biology and Applications
- Metabolomics and Mass Spectrometry Studies
- Aquaculture disease management and microbiota
- Plant and fungal interactions
- Plant Pathogens and Fungal Diseases
- Toxin Mechanisms and Immunotoxins
- Nicotinic Acetylcholine Receptors Study
- Marine Toxins and Detection Methods
- Phytochemicals and Antioxidant Activities
- Meat and Animal Product Quality
- Chemical Thermodynamics and Molecular Structure
- Phytoestrogen effects and research
- Pesticide Residue Analysis and Safety
- Bee Products Chemical Analysis
- Microbial infections and disease research
- Phytochemical Studies and Bioactivities
- Polysaccharides and Plant Cell Walls
- Analytical Chemistry and Chromatography
- Gut microbiota and health
Norwegian Veterinary Institute
2014-2025
Nordic Institute of Dental Materials
2024
Ghent University Hospital
2024
Swedish Veterinary Agency
2009
Ciguatera poisoning (CP) is a severe seafood-borne disease, caused by the consumption of reef fish contaminated with Caribbean ciguatoxins (C-CTXs) in and tropical Atlantic. However, C-CTXs have not been identified from their presumed algal source, so relationship to CTXs causing illness remains unknown. This has hindered development detection methods, diagnostics, monitoring programs, limited fundamental knowledge on environmental factors that regulate C-CTX production. In this study, vitro...
The aim of this study was to determine the toxicokinetic characteristics ZEN and its modified forms, α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), zearalenone-14-glucoside (ZEN14G), zearalenone-14-sulfate (ZEN14S), including presystemic systemic hydrolysis in pigs. Crossover pig trials were performed by means intravenous oral administration forms. Systemic plasma concentrations administered toxins their metabolites quantified further processed via tailor-made compartmental models. Furthermore,...
Enniatins are cyclic hexadepsipeptidic mycotoxins with ionophoric, antibiotic, and insecticidal activity. Enniatin B (EnnB), the most important analogue, is produced by many Fusarium species a common contaminant in grain-based foods. The compound's cytotoxic potential has been shown different experiments; however, mode of action not detailed so far. In present study, several mutually confirmative experiments have performed indicating that EnnB-initiated cytotoxicity could be connected...
4-Deoxynivalenol is one of the most prevalent mycotoxins in grain-based food and feed products worldwide. Conjugation deoxynivalenol to glucuronic acid elimination via urine appears be major metabolism pathway, although with differing efficiency different species. In order make pure glucuronides for analytical methodologies available we intended enzymatically synthesize using rat human liver microsomes supplemented uridine 5′-diphosphoglucuronic alamethicin as detergent. Three were isolated...
Post-smolt Atlantic salmon (Salmo salar) were fed standard feed with added 2 or 6 mg kg–1 pure deoxynivalenol (DON), 0.8 2.4 ochratoxin A (OTA), no toxins for up to 8 weeks. The experiments performed in duplicate tanks 25 fish each per diet group, and the was given three 2-h periods day. After 3, weeks, 10 from group sampled. In following hours after last feeding at toxin elimination studied by sampling five time points. Analysis of DON OTA tissues plasma conducted liquid chromatography-mass...
Enniatins are cyclic hexapeptidic mycotoxins produced by fungi growing on field grains, especially in wet climates. They show considerable resistance to food and feed processing technologies might cause intoxication of humans animals. also under exploration as anticancer drugs. The observed difference vitro vivo toxicities suggests low absorption or fast elimination the enniatins after oral uptake. In study presented here, metabolism studies enniatin B were performed using rat, dog, human...
Oat ( Avena sativa L.) ranks seventh in the world cereal production and is considered to be an important source for many valuable components of nutritional biological importance, i.e. proteins, fats, carbohydrates, fibre, minerals vitamins. Because these properties amount oat used human consumption has increased progressively during last years. Unfortunately, quality this grain crop often compromised by mycotoxin contamination, which relatively ubiquitous despite efforts control problem....
This study determined the presence, levels and co-occurrence of mycotoxins in fish feeds Kenya. Seventy-eight ingredients were sampled from farms feed manufacturing plants analysed for 40 using high-performance liquid chromatography-high resolution mass spectrometry. Twenty-nine (73%) identified with 76 (97%) samples testing positive presence. Mycotoxins highest prevalences enniatin B (91%), deoxynivalenol (76%) fumonisin B1 (54%) while those maximum sterigmatocystin (<30.5-3517.1 µg/kg);...
Fish are exposed to xenobiotics in the water. Uptake occurs mainly through gills, which function as an exchange point with environment. The gills' ability detoxify harmful compounds by biotransformation is essential protection mechanism. enormous numbers of waterborne requiring ecotoxicological assessment makes it necessary replace vivo fish studies predictive vitro models. Here, we have characterized metabolic capacity ASG-10 gill epithelial cell line from Atlantic salmon. Inducible CYP1A...
Ergot alkaloids are mycotoxins which produced among fungi in the family Clavicipitaceae. Poisoning with ergot is an important veterinary problem animal husbandry and has recently also been recognised wild animals. While poisoning syndrome observed domestic animals such as cattle, horses sheep usually caused by endophyte-infected grass, ergotism Norwegian cervids probably due to infection of grasses Claviceps. Mass spectrometry today method choice for rapid qualitative quantitative...
Enniatins, a large group of cyclodepsipeptides, are widely distributed contaminants different crops intended for human and animal consumption. Enniatin B is one the principal analogues in species genus Fusarium , known to have ionophoric, antibiotic, insecticidal activity. Regardless considerable cytotoxic effects observed vitro enniatins been characterised as compounds with low acute toxicity vivo. The biotransformation enniatin has previously elucidated liver microsomes, 12 metabolites (M1...
New protein sources in fish feed require the assessment of carry-over potential contaminants and anti-nutrients from ingredients into fish, possible health risks for consumers. Presently, plant materials including wheat legumes make up largest part aquafeeds, so evaluation transfer capabilities typical toxic metabolites plant-infesting fungi vegetable phytoestrogens products is great importance. With aim facilitating surveillance relevant mycotoxins isoflavones, we have developed validated a...
Cyanobacteria are cosmopolitan photosynthetic prokaryotes that can form dense accumulations in aquatic environments. They able to produce many bioactive metabolites, some of which potentially endocrine disrupting compounds, i.e., compounds interfere with the hormonal systems animals and humans. Endocrine disruptors represent potential risks both environmental human health, making them a global challenge. The aim this study was investigate activities emphasis on estrogenic effects extracts...
Mucous membranes such as the gill and skin mucosa in fish protect them against a multitude of environmental factors. At same time, changes molecular composition mucus may provide valuable information about interaction with their environment, well health welfare. In this study, metabolite profiles plasma, freshwater Atlantic salmon (Salmo salar) were compared using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS). Several normalization procedures aimed reduce...
The tobacco alkaloid nicotine is known for its activation of neuronal nicotinic acetylcholine receptors. Nicotine consumed in different ways such as through conventional smoking, e-cigarettes, snuff or pouches. use has been associated with several adverse health effects, inflammatory reactions the oral mucosa and cavity cancer. We performed a metabolomic analysis nicotine-exposed THP-1 human monocytes. Cells were exposed to 5 mM up 4 h, cell extracts medium subjected untargeted liquid...
Metabolomic analysis has been explored to search for disease biomarkers in humans some time. The application animal species, including fish, however, is still at the beginning. In present study, we have used targeted and untargeted metabolomics identify metabolites plasma of Atlantic salmon (Salmo salar) challenged with Piscine orthoreovirus (PRV-1), aiming find associated progression PRV-1 infection into heart skeletal muscle inflammation (HSMI). metabolomes control PRV-1-infected were...