A5083028455- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Aquaculture disease management and microbiota
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- NF-κB Signaling Pathways
- Marine Toxins and Detection Methods
- Toxic Organic Pollutants Impact
- Plant Disease Resistance and Genetics
- DNA Repair Mechanisms
- Fungal Plant Pathogen Control
- Retinoids in leukemia and cellular processes
- Physiological and biochemical adaptations
- Ion Transport and Channel Regulation
- Immunotoxicology and immune responses
- Aquaculture Nutrition and Growth
- Metabolism, Diabetes, and Cancer
- Amino Acid Enzymes and Metabolism
- Invertebrate Immune Response Mechanisms
- Inflammatory mediators and NSAID effects
- Plant Disease Management Techniques
- Immune Response and Inflammation
- Animal Virus Infections Studies
Norwegian Veterinary Institute
2016-2025
Swedish Veterinary Agency
2010
University of Oslo
2008
Oslo University Hospital
2008
Norwegian Institute of Public Health
2003-2007
Norwegian University of Science and Technology
2001
As a complex system governing and interconnecting numerous functions within the human body, immune is unsurprisingly susceptible to impact of toxic chemicals. Toxicants can influence through multitude mechanisms, resulting in immunosuppression, hypersensitivity, increased risk autoimmune diseases cancer development. At present, regulatory assessment immunotoxicity chemicals relies heavily on rodent models limited number Organisation for Economic Co-operation Development (OECD) test...
In this study we show that benzo[ a ]pyrene (B[ ]P) and the cyclopenta polycyclic aromatic hydrocarbons (CP-PAH) cyclopenta[ c , d (CPP), benz[ j ]aceanthrylene ]A) l induce apoptosis in Hepa1c1c7 cells, as measured by fluorescence microscopy flow cytometry. The compounds induced formation of active form caspase-3, cleavage its intracellular substrate, poly(ADP-ribose)polymerase (PARP), DNA fragmentation. B[ ]A was found to be most potent inducing apoptosis, followed ]P, CPP ]A. All...
Fish-killing harmful algal blooms (HABs) threaten fisheries and aquaculture globally. In May June 2019, the haptophyte Chrysochromulina leadbeateri formed most devastating fish-killing bloom ever recorded in Northern Norway. Despite severe impact of HABs on farmed fish, our understanding their toxic mechanisms is limited. Here, we investigated ichthyotoxicity C. by using gill epithelial cell line ASG-10 from Atlantic salmon. Extracts showed potent hemolytic activity towards salmon red blood...
Enniatins are cyclic hexadepsipeptidic mycotoxins with ionophoric, antibiotic, and insecticidal activity. Enniatin B (EnnB), the most important analogue, is produced by many Fusarium species a common contaminant in grain-based foods. The compound's cytotoxic potential has been shown different experiments; however, mode of action not detailed so far. In present study, several mutually confirmative experiments have performed indicating that EnnB-initiated cytotoxicity could be connected...
Here we evaluated the gill epithelial cell line ASG-10 from Atlantic salmon, as an in vitro model for research on known water quality challenges aquaculture. Ammonia/ammonium (NH3/NH4+), a recognized challenge water-intensive recirculating aquaculture systems (RAS), induced lysosomal vacuolization, reduced protein degradation and migration of cells. Aluminium (Aln+), another freshwater facilities had only minor effects. Next, investigated tolerance direct exposure ASG-10. The cells tolerated...
Tumor necrosis factor (TNF)-α and interleukin (IL)-1β are potent activators of the transcription NF-κB, induced during inflammatory conditions. We have previously shown that both secretory cytosolic phospholipase A2(PLA2) involved in TNF-α- IL-1β-induced NF-κB activation. In this study, we addressed mechanism PLA2 involvement with respect to downstream arachidonic acid (AA) metabolites functional coupling between PLA2s mediating show addition inhibitors PLA2s, 5-lipoxygenase attenuate...
Fish gills are not only the respiratory organ, but also essential for ion-regulation, acid-base control, detoxification, waste excretion and host defense. Multifactorial gill diseases common in farmed Atlantic salmon, still poorly understood. Understanding pathophysiology is of paramount importance, sacrifice large numbers experimental animals this purpose should be avoided. Therefore, vitro models, such as cell lines, urgently required to replace fish trials. An salmon epithelial line,...