A5054409337- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Animal Nutrition and Physiology
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Metabolomics and Mass Spectrometry Studies
- Animal Genetics and Reproduction
- Dementia and Cognitive Impairment Research
- Animal Behavior and Welfare Studies
- Child and Adolescent Psychosocial and Emotional Development
- Health, Environment, Cognitive Aging
- Gut microbiota and health
- Retinal Imaging and Analysis
- Birth, Development, and Health
- Diet and metabolism studies
- Computational Drug Discovery Methods
- Health Systems, Economic Evaluations, Quality of Life
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related cognitive impairment studies
- Child and Animal Learning Development
- Social Media in Health Education
- Animal testing and alternatives
- Cardiovascular Health and Risk Factors
- Mindfulness and Compassion Interventions
Banyan Biomarkers (United States)
2025
Montana State University
2018-2024
Moderna Therapeutics (United States)
2023
Cohen Veterans Bioscience
2020-2023
University of Tennessee at Knoxville
2019-2022
University of Michigan
2016-2020
Wayne State University
2018-2020
John D. Dingell VA Medical Center
2019
Pennsylvania State University
2013-2016
Park University
2015
The term "stress" is used to describe important phenomena at multiple levels of biological organization, but finding a general and rigorous definition the concept has proven challenging. Current models in behavioral literature emphasize cognitive aspects stress, which said occur when threats organism are perceived as uncontrollable and/or unpredictable. Here we adopt perspective systems biology take step toward stress by unpacking light control theory. Our goal clarify so facilitate...
Abstract INTRODUCTION Understanding longitudinal change in key plasma biomarkers will aid detecting presymptomatic Alzheimer's disease (AD). METHODS Serial samples from 424 Wisconsin Registry for Prevention participants were analyzed phosphorylated‐tau217 (p‐tau217; ALZpath) and other AD biomarkers, to study trajectories relation disease, health factors, cognitive decline. Of the participants, 18.6% with known amyloid status positive (A+); 97.2% cognitively unimpaired (CU). RESULTS In CU,...
The potential diagnostic value of plasma amyloidogenic beta residue 42/40 ratio (Aβ42/Aβ40 ratio), neurofilament light (NfL), tau phosphorylated at threonine-181 (p-tau181), and threonine-217 (p-tau217) has been extensively discussed in the literature. We have also previously described association between retinal biomarkers preclinical Alzheimer's disease (AD). goal this study was to evaluate association, a multimodal model of, for detection AD. included 82 cognitively unimpaired (CU)...
Animals that experience adverse events in early life often have life-long changes to their physiology and behavior. Long-term effects of stress during been studied extensively, but less attention has given the consequences negative experiences solely adolescent phase. Adolescence is a particularly sensitive period when regulation glucocorticoid "stress" hormone response matures specific regions brain undergo considerable change. Aversive this time might, therefore, be expected generate...
There is mounting evidence of systemic inflammation in post-traumatic stress disorder (PTSD) and Parkinson's disease (PD), yet inconsistency a lack replicability findings putative biological markers have delayed progress this space. Variability performance between platforms may contribute to the consensus biomarker literature, as has been seen for number psychiatric disorders, including PTSD. Thus, there need high-performance, scalable, validated discovery development biomarkers use drug...
Objective: Rare diseases, including many rare genetic epilepsies and neurodevelopmental disorders, present significant challenges in timely diagnosis, treatment, patient education due to their incidence, complex clinical nature lack of standardized care pathways. Despite advancements testing, knowledge dissemination remains inadequate, contributing delayed diagnosis inconsistent management. Addressing these gaps requires innovative educational approaches tailored diverse audiences, patients,...
Recently we have shown that adult rats exposed to chronic stress during adolescence increase foraging performance in high-threat conditions by 43% compared reared without stress. Our findings suggest can prepare better function under future threat, which supports hypotheses describing an adaptive role for the long-term consequences of early (e.g. thrifty phenotype and maternal mismatch hypotheses). These often predict will impair low-threat later life. However, did not find any difference...
HIGHLIGHTS This study tested the effects of adolescent-stress on adult learning and memory.Adolescent-stressed rats had enhanced reversal compared to unstressed rats.Adolescent-stress exposure made working memory more vulnerable disturbance.Adolescent-stress did not affect associative or reference memory. Exposure acute stress can cause a myriad cognitive impairments, but whether negative experiences continue hinder individual as they age is well understood. We determined how chronic...
Abstract Mild traumatic brain injury (mTBI) is among the most common injuries sustained by post-9/11 veterans; however, these often occur within context of psychological trauma. Blast exposure, even in absence a diagnosable TBI, leads to changes neural connectivity and congitive functioning. Therefore, considering clinical comorbidities characteristics critical understanding long-term effects mTBI. Research moving towards identifying diagnostic prognostic blood-based biomarkers for TBI; few...
Spatial abilities allow animals to retain and cognitively manipulate information about their spatial environment are dependent upon neural structures that mature during adolescence. Exposure stress in adolescence is thought disrupt maturation, possibly compromising cognitive processes later life. We examined whether exposure chronic unpredictable affects ability late adulthood. evaluated learning, reference working memory, as well long-term retention of visuospatial cues using a radial arm...
Stress exposure can cause lasting changes in cognition, but certain individual traits, such as cognitive flexibility, have been shown to reduce the degree, duration, or severity of following stress. Both stress and flexibility training affect decision making by modulating monoamine signaling. Here, we test role training, high vs. low at level, attenuating stress-induced memory levels using single prolonged (SPS) rodent model traumatic male Sprague-Dawley rats. Exposure SPS heighten fear...
Abstract Stress in adolescence can regulate vulnerability to traumatic stress adulthood through region-specific epigenetic activity and catecholamine levels. We hypothesized that would increase adult trauma by impairing extinction-retention, a deficit PTSD, (1) altering class IIa histone deacetylases (HDACs), which integrate effects of on gene expression, (2) enhancing norepinephrine brain regions regulating cognitive trauma. investigated the adolescent-stress severe using single-prolonged...
Evidence for and against adolescent vulnerability to posttraumatic stress disorder (PTSD) is mounting, but this evidence largely qualitative, retrospective, or complicated by variation in prior exposure trauma context. Here, we examine the effects of development on using adult (early mid adolescence) rats two types trauma: an established animal model PTSD, single prolonged (SPS), a novel composite - stress-predation version (SPSp). We demonstrate first time that early are capable fear safety...
Metabolomics methods often encounter trade-offs between quantification accuracy and coverage, with truly comprehensive coverage only attainable through a multitude of complementary assays. Due to the lack standardization variety metabolomics assays, it is difficult integrate datasets across studies or To inform platform selection, focus on posttraumatic stress disorder (PTSD), we review use sample sizes in psychiatric then evaluate five prominent platforms for performance, including...
Abstract Exposure to chronic stress during adolescence can shape behaviour, cognition and physiology in adulthood, but the consequences of these long‐term changes remain unclear. Prior studies reporting altered performance following exposure have generally interpreted lasting as impairments. However, we recently shown that unpredictable (from post‐natal days 30–70) enhance a context‐dependent manner foraging task. Increases performance, (previously measured by number rewards obtained), are...
Abstract Background Blood‐based AD biomarker tests will be essential clinical tools to provide accessible and affordable screening monitoring for disease‐modifying therapeutics (DMT) as well advancing overall care. Tau phosphorylated at position 217 (pTau217) is considered have the highest accuracy in identifying Alzheimer’s disease (AD) pathology using blood. We describe a multi‐cohort evaluation of Simoa ALZpath pTau217 assay plasma, including memory clinic patients, performance context...