A5071247699- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Menopause: Health Impacts and Treatments
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Alzheimer's disease research and treatments
- Inflammasome and immune disorders
- Menstrual Health and Disorders
- Salivary Gland Disorders and Functions
- Cytokine Signaling Pathways and Interactions
- Cancer-related cognitive impairment studies
- Reproductive System and Pregnancy
- Phytochemistry and biological activity of medicinal plants
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lipid metabolism and disorders
- Prostate Cancer Diagnosis and Treatment
- Hair Growth and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Traditional Chinese Medicine Analysis
- Advanced Computational Techniques and Applications
- Pluripotent Stem Cells Research
- Synthesis and pharmacology of benzodiazepine derivatives
- Medicinal Plant Pharmacodynamics Research
- Genomics, phytochemicals, and oxidative stress
Guangzhou University of Chinese Medicine
2011-2024
Guangzhou University
2005-2014
In neurodegenerative diseases, microglial activation and neuroinflammation are essential for the control progression of diseases. Mitigating microglium-induced inflammation is one strategy hindering Ferulic acid (FA) an effective anti-inflammatory agent, but its potential role regulation mechanism in neuroinflammatory reactions have not been fully studied. this study, model was established by lipopolysaccharide (LPS), inhibitory effect FA on BV2 microglia The results showed that...
Microglia hyperactivation is an important cause of neuroinflammation in Alzheimer's disease (AD). Paeoniflorin (PF), ferulic acid (FA), and atractylenolide III (ATL) are potent anti-inflammation neuroprotection. Multiple components can act on different targets simultaneously to exert synergistic therapeutic effects exploring the potential between compounds area research. We investigated PF, FA, ATL, alone or combination, LPS-induced autophagy BV2 microglia cells. found that significantly...
This study aims to establish a diagnostic scoring scheme for Shanghuo (Heatiness) and evaluate whether is associated with biochemical parameters of salivary lysozyme (LYZ), secreted immunoglobulin (S-IgA), amylase (AMS), saliva flow rate (SFR).We collected 121 patients at the Affiliated Hospitals Guangzhou University Traditional Chinese Medicine in Guangdong Province, 60 cases as recovered group, healthy control group. The was established by probability theory maximum likelihood...
Alzheimer's disease (AD) is a neurodegenerative brain disorder that progressively impairs long-term and working memory. The function mechanism of PA(Patchouli alcohol) in improving AD the external treatment encephalopathy remain unclear. This study aimed to investigate therapeutic effect PA on using an Aβ
Danggui Shaoyao San (DSS), a frequently prescribed Chinese medicine formula, has demonstrated clinical efficacy in the treatment of Alzheimer's disease (AD). This study aims to explore differences therapeutic effects DSS and its disassembled prescriptions, Suangan (SG) Xingan (XG), treating Disease mechanism recovering autophagy AD.
Salvianolic acid B (SB) is an antioxidant derived from Salvia militarize, and one of the most widely used herbs in traditional Chinese medicine. SB a potent that has been well documented as scavenger oxygen free radicals, for prevention treatment atherosclerosis‑associated disorders. To explore its potential therapeutic effects treating radiation damage, this study, mice were treated with at different doses 5, 12.5 20 mg/kg, subsequent to receiving γ‑irradiation. The on peripheral blood,...
Abstract A synthetic approach of isoindolinones through intramolecular amidation ortho ‐vinyl benzamides was reported. variety N ‐aryl isoindolinone derivatives were prepared in moderate to excellent yields using perfluorobutyl iodide as oxidant. magnified image
The polarization of T helper (Th) cells plays an important role in the inflammatory response, pathogen removal, and tissue damage processes infectious acute lung injury (ALI). However, Th cell viral- or bacterial-mediated ALI is not well defined. Herein, influenza virus (A/FM/1/47, H1N1) lipopolysaccharide (LPS) were chosen to induce mice, resultant diversity Th-cell was explored.BALB/c mice challenged intranasally with LPS. Edema lung, infiltration (macrophages, neutrophils, lymphocytes),...
The establishment of human-induced pluripotent stem cell (iPSC) models from sporadic Alzheimer’s disease (sAD) patients is necessary and could potentially benefit research into etiology therapeutic strategies. However, the development sAD iPSC still limited due to multifactorial nature disease. Here, we extracted peripheral blood mononuclear cells (PBMCs) a patient with induced them by introducing Sendai virus expressing Oct3/4, Sox2, c-Myc, Klf4, which were subsequently neural build model...
Objective To study the effect of Chinese medicine hair-restoring lotion on proliferation in vitro human epiderm keratinocytes (HEK). Methods Taking Zhangguang 101 as a positive drug, cultured HEK by using enzymatic digestion, observed morphology cells, determined growth activity MTT assay, and drew curve cells each group, to evaluate vitro. Results Compared with blank control administrated 24 h later, group increased number, some were connected other, there was no transparent...