A5101825956- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Colorectal Cancer Screening and Detection
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Nausea and vomiting management
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Anesthesia and Sedative Agents
- Clinical Nutrition and Gastroenterology
- Phosphodiesterase function and regulation
- Cardiac electrophysiology and arrhythmias
- Dietetics, Nutrition, and Education
- Digestive system and related health
- Esophageal Cancer Research and Treatment
- Interprofessional Education and Collaboration
- Gallbladder and Bile Duct Disorders
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Genetic and phenotypic traits in livestock
- Epilepsy research and treatment
- Drug-Induced Hepatotoxicity and Protection
- Global Health Workforce Issues
Cairns Hospital
2008-2024
Eisai (United States)
2022
James Cook University
2007-2020
Eisai (United Kingdom)
2019
Royal Marsden Hospital
1978
Institute of Cancer Research
1978
Duodenal perforation is an uncommon complication of endoscopic retrograde cholangio-pancreatography (ERCP) and a rare upper gastrointestinal endoscopy. Most are minor perforations that settle with conservative management. A few however result in life-threatening retroperitoneal necrosis require surgical intervention. There relative paucity references specifically describing the interventions required for this eventuality.Five cases iatrogenic duodenal were ascertained between 2002 2007 at...
Abstract Background & Aims Incidence and mortality of hepatocellular carcinoma ( HCC ) is increasing globally, but varies between countries regions. To target scarce resources to most need, clinical services must be informed by regional epidemiology. Using population‐based data, we sought document the incidence in Queensland, Australia, a state occupying vast land area with diverse at‐risk subpopulations. Methods data from 1996 2011, age‐standardised rate ASR ), annual percentage change...
Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) has excellent cure rates and minimal side effects. Despite the high burden of disease, strategies to ultimately eradicate HCV are being developed. However, delivery care in regional settings is challenging efficacy decentralised models incompletely defined. A prospective cohort study patients whose treatment was initiated or supervised by Cairns Hospital, a tertiary hospital which provides services culturally diverse...
Aboriginal and Torres Strait Islander Australians living in remote locations suffer disproportionately from chronic hepatitis B (CHB). Defining the temporospatial epidemiology of disease-and assessing ability local clinicians to deliver optimal care-is crucial improving patient outcomes these settings.The demographic, laboratory radiology findings all patients diagnosed with CHB after 1990, presently residing Far North Queensland (FNQ), tropical Australia, were correlated their management...
Oxycodone is a widely-used semisynthetic opioid analgesic that has been used for over eighty years. known to cause side effects such as nausea, pruritus, dizziness, constipation and somnolence. As far we are aware cholestatic hepatitis result of oxycodone use not reported so in the world literature. A 34-year-old male presented with jaundice severe pruritus after receiving analgesia post-T11 vertebrectomy. Extensive laboratory investigations imaging studies did reveal any other obvious his...
Abstract Background and Aim Endoscopist directed nurse administered propofol sedation (EDNAPS) is widely considered to be safe efficient, but there are limited data from the Australian health‐care setting, guidelines do not support practice. Thus, we report a prospective audit of EDNAPS over 6.5‐year period in an referral hospital. Methods Consecutive endoscopic procedures performed between January 2013 June 2019. Sedation protocol was initial dose midazolam 1–3 mg intravenously (i.v.) 10–50...
Abstract Background Hepatitis C virus (HCV) infection can now be cured with well-tolerated direct-acting antiviral (DAA) therapy. However, a potential barrier to HCV elimination is the emergence of resistance-associated substitutions (RASs) that reduce efficacy drugs, but real-world studies assessing clinical impact RASs are limited. Here, an analysis on retreatment outcomes for different salvage regimens in patients nationally who failed first-line DAA therapy reported. Methods We collected...
Accurate definition of metastases in para-aortic lymph nodes and lungs is essential planning treatment for patients with testicular teratoma. The addition CT scanning to routine investigation these has given additional sensitivity detection localisation metastases. extent could be clearly defined, even when bulk replacement prevented by lymphography. This information was used the best surgical approach lymphadenectomy, which done as part combined large volume
Abstract Background and Aims: There is very little information known about esophageal cancer in Indigenous persons. In this retrospective study, we investigated the epidemiological clinical features of Australians with cancer. Methods: A study was carried out on non‐Indigenous diagnosed at Cairns Base Hospital during period 1 January 2001 to 31 December 2006. Information obtained from hospital medical records, Queensland Cancer Registry survival data Health Pathology Services laboratory...
Australian and international guidelines suggest that immunochemical faecal occult blood test (iFOBT) for colorectal cancer (CRC) screening may be deferred 5–10 years after a negative colonoscopy. However, it is not uncommon community health practitioners to repeat iFOBT at earlier than
Abstract Data from a large Hereford bull breeding herd in South Canterbury, New Zealand, were analysed to estimate genetic parameters for liveweights and three reproductive traits. The records comprised yearling weight (YW) both sexes, 18-month (final) (FW) on bulls, scrotal circumference (SC), serving capacity of bulls recorded two ways, first as the number serves standard time (serving number, SN), second grade grade, SG). There 8 years data available (1982–89 calf crops), comprising 2414...
Purpose: A 40 year old Caucasian lady from a rural community near Cairns presented to our gastroenterology clinic for investigation of chronic diarrhoea since infancy. She passed at least 8 bulky stools per day and her bloating flatulence had been worsening recently. Past medical history was otherwise unremarkable. on no medications. Physical examination normal. Her family significant deceased brother who infancy that also never investigated. dietary notable avoidance sugary foods early...
May 5, 2019April 9, 2019Free AccessPharmacokinetic (PK) Assessment of Perampanel Intravenous (IV) Formulation as a Bioequivalent Alternative to Oral Tablet Administration (P1.5-029)Larisa Reyderman, Jim Ferry, Leock Y. Ngo, Min-Kun Chang, Jagadeesh Aluri, Peter Boyd, and Ziad HusseinAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P1.5-029 Letters the Editor
INTRODUCTION: Australian and international guidelines suggest that immunochemical faecal occult blood test (iFOBT) for colorectal cancer (CRC) screening may be deferred 5–10 years after a negative colonoscopy. The aim of this retrospective multicentre observational study was to evaluate the outcomes patients who had repeat colonoscopy iFOBT positivity within five previous showing low risk or normal findings, assess interval CRC advanced neoplasia (ACRN). We sought determine if having prior...
Background: E2027 is a novel, highly selective and potent inhibitor of phosphodiesterase 9 in development for dementia with Lewy bodies. Cardiac safety assessments emerging agents are essential to avoid drug-induced QT interval prolongation, which may predispose individuals potentially fatal ventricular arrhythmias. To evaluate the cardiac inform dose selection phase 2 study bodies, we evaluated concentration-response modeling pooled electrocardiogram data. Patients Methods: A post hoc...