A5016775792- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- Innovations in Medical Education
- Pancreatic and Hepatic Oncology Research
- Clinical Reasoning and Diagnostic Skills
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Pelvic and Acetabular Injuries
- Pediatric Hepatobiliary Diseases and Treatments
- Hernia repair and management
- Adolescent Sexual and Reproductive Health
- Radiology practices and education
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- LGBTQ Health, Identity, and Policy
- Health Sciences Research and Education
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- 3D Printing in Biomedical Research
- Gastrointestinal disorders and treatments
- Structural Integrity and Reliability Analysis
- Frailty in Older Adults
- Esophageal and GI Pathology
- Abdominal Surgery and Complications
Royal Hobart Hospital
2018-2025
University of Tasmania
2016-2025
King's College London
2022-2024
BioPharm (United Kingdom)
2022
National Centre for Social research
2021
UNSW Sydney
2021
AstraZeneca (United Kingdom)
2021
CTI BioPharma (United Kingdom)
2019
Aimmune Therapeutics (United Kingdom)
2019
Karolinska Institutet
2018
The discovery that the AP-1 family of enhancer binding factors includes a complex cellular Fos (cFos) and Jun (cJun) proteins established direct important link between oncogenesis transcriptional regulation. Homodimeric cJun protein synthesized in vitro is capable selectively to recognition sites, whereas cFos polypeptide not. When cotranslated, can form stable, heterodimeric with DNA properties AP-1/cJun. related B vJun are also able complexes cFos. Directed mutagenesis reveals leucine...
Knowledge and understanding of basic biomedical sciences remain essential to medical practice, particularly when faced with the continual advancement diagnostic therapeutic modalities. Evidence suggests, however, that retention tends atrophy across span an average course into early postgraduate years, as preoccupation clinical medicine predominates. We postulated perceived relevance demonstrated through applicability situations may assist in science knowledge.To test this hypothesis our own...
Abstract Background The experiences of gay, bisexual, and other men who have sex with (GBMSM) receiving anorectal surgery are not well understood, including their interaction surgeons the impact on receptive anal intercourse. This pilot exploratory study aimed to understand GBMSM recently received surgery. Methods mixed methods utilized surveys semi‐structured interviews gay bisexual operative treatment by a general or colorectal surgeon for benign condition within Australia. Descriptive...
Background Evidence suggests a varied level of sexual health literacy (SHL) among university student populations, so we evaluated the SHL students at University Tasmania.Students were invited to complete an anonymous online questionnaire during August/September 2013. was assessed using ARCSHS National Survey Australian Secondary Students & Sexual Health (ARC) and Questionnaire (SHS). Predictors scores by linear regression.The study recruited 1786 participants (8.2% 2013 population), similar...
Glucose control is vital to ensure consistent growth and protein production in mammalian cell cultures. The typical fed‐batch glucose strategy involving bolus additions based on infrequent off‐line daily samples results cells experiencing significant concentration fluctuations that can influence product quality growth. This study proposes an on‐line method manipulate utilizing readily available process measurements. generates a correlation between the cumulative oxygen transfer rate...
This paper describes a method of predicting constant flow filtration capacities using pressure datasets collected during the purification several monoclonal antibodies through depth filtration. The required characterisation fouling mechanism occurring in processes by evaluating best fit each classic and combined theoretical models. optimised coefficients various models were correlated with corresponding achieved operation at specific pressures performed for centrate. Of investigated,...
Multivariate data analysis (MVDA) is a highly valuable and significantly underutilized resource in biomanufacturing. It offers the opportunity to enhance understanding leverage useful information from complex high-dimensional sets, recorded throughout all stages of therapeutic drug manufacture. To help standardize application promote this within biopharmaceutical industry, paper outlines novel MVDA methodology describing necessary steps for efficient effective analysis. The followed solve...
Duodenal perforation is an uncommon complication of endoscopic retrograde cholangio-pancreatography (ERCP) and a rare upper gastrointestinal endoscopy. Most are minor perforations that settle with conservative management. A few however result in life-threatening retroperitoneal necrosis require surgical intervention. There relative paucity references specifically describing the interventions required for this eventuality.Five cases iatrogenic duodenal were ascertained between 2002 2007 at...
Abstract Introduction Knowledge of the size liver is an important factor in diagnosing disease. Hepatomegaly a term used to describe that enlarged beyond its normal dimensions, and ultrasound often front line investigation suspicion hepatomegaly. This study sought develop reference range for using simple, reliable valid measurement technique. Methods Two images blood test were taken from 126 participants. Three simple linear measurements these two converted volume published equation. Results...
Prompt diagnosis of choledocholithiasis is crucial for reducing disease severity, preventing complications and minimizing length stay. Magnetic resonance cholangiopancreatography (MRCP) commonly used to evaluate patients with suspected but expensive may delay definitive intervention. To optimize patient care resource utilization, we have developed five machine learning models that predict a patients' risk based on clinical presentation pre-MRCP investigation results.
The environmental impact of large language models (LLMs) in medicine spans carbon emission, water consumption and rare mineral usage. Prior-generation LLMs, such as GPT-3, already have concerning impacts. Next-generation GPT-4, are more energy intensive used frequently, posing potentially significant harms. We propose a five-step pathway for clinical researchers to minimise the natural algorithms they create.
Objective Structured Clinical Examinations (OSCEs) have been used globally in evaluating clinical competence the education of health professionals. Despite objective intent OSCEs, scoring methods by examiners a potential source measurement error affecting precision with which test scores are determined. In this study, we investigated differences inter-rater reliabilities checklist and subjective global rating (who were exposed to an online training program standardise techniques) across two...
The optimization of bioprocesses for biopharmaceutical manufacturing by Chinese hamster ovary (CHO) cells can be a challenging endeavor and, today, heavily relies on empirical methods treating the bioreactor process and as black boxes. Multi-omics approaches have potential to reveal otherwise unknown characteristics these systems identify culture parameters more rationally optimize cultivation process. Here, authors applied both metabolomic proteomic profiling perfusion process, using CHO...
Host cell proteins (HCP) that co-purify with biologics produced in Chinese hamster ovary cells have been shown to impact product quality through proteolytic degradation of recombinant proteins, leading potential losses. Several problematic HCPs can remain the final even after extensive purification. Each line has a unique HCP profile be determined by numerous upstream and downstream factors, including clonal variation protein sequence expressed therapeutic molecule. Here, we worked lines...
In recent years, mRNA-based therapeutics have been a fast-growing new class of biologics that can, in principle, encode any protein(s) directly patients to treat various diseases. mRNA vaccines proven work efficiently, high potency, and can be rapidly developed deployed, which is critical for quick responses the case pandemic. Such agile development enabled by rapid synthesis RNA vitro using recombinant enzymes rather than relying on lengthy complex cell culture processes. exhibits physical...
The aim of this study was to assess the risk clinical thromboembolism in laparoscopic digestive surgery. From June 1992 1997, 2,384 consecutive patients were studied. All received perioperative prophylaxis with low-molecular-weight heparin (LMWH), which continued until full mobility regained. Eight cases (0.33%) deep venous thrombosis noted, but there no pulmonary embolus. In six (five cholecystectomies reverse Trendelenburg position and one inguinal hernia repair), release pneumoperitoneum...
Sonography is an effective, noninvasive, safe, and inexpensive technique for measurement of the liver. Measurements liver using 2D ultrasound aid in diagnosing tracking disease surgical planning. Multiple studies have developed techniques to measure adult ultrasound. The aim this systematic literature review was determine whether a correctly developed, reliable, reproducible measuring has been reported. Analysis meeting inclusion criteria showed that none these rigorously undertaken terms...
This paper considers a real-world optimization problem involving the identification of cost-effective equipment sizing strategies for sequence chromatography steps employed to purify biopharmaceuticals. Tackling this requires solving combinatorial subject multiple constraints, uncertain parameters, and time-consuming fitness evaluations.An industrially-relevant case study is used illustrate that evolutionary algorithms can identify with significant improvements in performance criteria...