A5047162912- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- CRISPR and Genetic Engineering
- Cancer-related Molecular Pathways
Instituto de Investigación Sanitaria del Principado de Asturias
2022-2024
Universidad de Oviedo
2022-2024
Abstract Background Tumor mutational burden (TMB) has been demonstrated to predict the response immune checkpoint inhibitors (ICIs) in various cancers. However, role of TMB head and neck squamous cell carcinoma (HNSCC) not yet specifically addressed. Since HNSCC patients exhibit a rather limited ICIs, there is an unmet need develop predictive biomarkers improve patient selection criteria clinical benefit ICI treatment. Methods We conducted systematic review meta-analysis according Preferred...
Abstract Background There is growing evidence regarding the prognostic utility of ratios such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR), and systemic immune‐inflammatory index (SIII) in head neck squamous cell carcinoma (HNSCC). However, most studies to date include heterogeneous series with different treatments or tumor subsites. Methods We collected data from 201 patients stage I–II glottic treated transoral laser surgery. NLR, PLR, SIII were calculated...
<title>Abstract</title> <bold>Background:</bold> Head and neck squamous cell carcinoma (HNSCC) remains a challenging prevalent lethal malignancy, with still scarce targeted therapies rather limited clinical benefit. We conducted an optimized genome-wide functional CRISPR screen aimed at identifying actionable genetic vulnerabilities for rapid preclinical evaluation as novel therapies. Cyclin-dependent kinases (CDKs) were prioritized pivotal in cancer therapy. <bold>Methods:</bold>...
Activation of WNT/β-catenin signaling has been associated with a non-T-cell-inflamed tumor microenvironment (TME) in several cancers. The aim this work was to investigate the relationship between β-catenin and TME inflammation head neck squamous cell carcinomas (HNSCCs). Membrane nuclear expression, PD-L1 CD8+ tumor-infiltrating lymphocyte (TIL) density were jointly evaluated by immunohistochemistry series 372 HPV-negative HNSCCs. levels decreased compared normal epithelium. Positive...