A5052434390- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Ear and Head Tumors
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Vascular Malformations Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Hearing, Cochlea, Tinnitus, Genetics
- RNA modifications and cancer
- Immune cells in cancer
- Neurofibromatosis and Schwannoma Cases
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Parathyroid Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Cerebral Venous Sinus Thrombosis
- Thyroid and Parathyroid Surgery
- Historical Studies in Science
- Wnt/β-catenin signaling in development and cancer
- Vestibular and auditory disorders
Instituto de Investigación Sanitaria del Principado de Asturias
2019-2025
Hospital Universitario De Cabueñes
2025
Universidad de Oviedo
2018-2024
Centro de Investigación Biomédica en Red de Cáncer
2021-2024
Instituto de Salud Carlos III
2021-2024
Central University Hospital of Asturias
2013-2021
University of Bari Aldo Moro
2015
The University of Sydney
2015
University Hospital Complex Of Vigo
2006
Abstract Background Tumor mutational burden (TMB) has been demonstrated to predict the response immune checkpoint inhibitors (ICIs) in various cancers. However, role of TMB head and neck squamous cell carcinoma (HNSCC) not yet specifically addressed. Since HNSCC patients exhibit a rather limited ICIs, there is an unmet need develop predictive biomarkers improve patient selection criteria clinical benefit ICI treatment. Methods We conducted systematic review meta-analysis according Preferred...
Dental disease is more extensive in adults with chronic kidney disease, but whether dental health and behaviors are associated survival the setting of hemodialysis unknown.Prospective multinational cohort.4,205 treated long-term hemodialysis, 2010 to 2012 (Oral Diseases Hemodialysis [ORAL-D] Study).Dental as assessed by a standardized examination using World Health Organization guidelines personal oral care, including edentulousness; decayed, missing, filled teeth index; brushing flossing;...
The SOX2 gene located at 3q26 is frequently amplified and overexpressed in multiple cancers, including head neck squamous cell carcinomas (HNSCC). tumor-promoting activity involvement of tumor progression has been extensively demonstrated, thereby emerging as a promising therapeutic target. However, the role early stages tumorigenesis its possible contribution to malignant transformation remain unexplored. This study investigates for first time protein expression by immunohistochemistry...
Lectin-like transcript 1 (LLT1) expression by tumor cells contributes to immune evasion, thereby emerging as a natural killer (NK) cell-mediated immunotherapeutic target. This study is the first investigate LLT1 (encoded CLEC2D gene) in head and neck cancers ascertain its impact on patient prognosis. was analyzed immunohistochemistry homogeneous cohort of human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinomas (OPSCC), correlated with clinical data. Results were further...
Background: We performed a comparative analysis between an organ-preservation protocol and surgery followed by radiotherapy in patients with locally advanced squamous cell carcinoma of the larynx hypopharynx; Methods: 60 previously untreated who were treated induction chemotherapy chemoradiotherapy responders compared control group up-front surgery. Both groups statistically comparable, according to subsite, TNM (tumor-node-metastasis) stage, age, sex; Results: Mean age was 58 years 92%...
Our goal was to assess the correlation of immune parameters with response induction chemotherapy (ICT) in head and neck squamous cell carcinoma (HNSCC) patients. Pretreatment biopsies from 64 patients HNSCC that received ICT were assessed for PD-L1 protein expression density CD8+ FOXP3+ tumor infiltrating lymphocytes (TIL). In addition, neutrophil-to-lymphocyte ratio (NLR) calculated pretreatment whole blood counts. total, 55% cases exhibited combined proportion score (CPS) positivity (≥1%...
Abstract Background There is growing evidence regarding the prognostic utility of ratios such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR), and systemic immune‐inflammatory index (SIII) in head neck squamous cell carcinoma (HNSCC). However, most studies to date include heterogeneous series with different treatments or tumor subsites. Methods We collected data from 201 patients stage I–II glottic treated transoral laser surgery. NLR, PLR, SIII were calculated...
Ototoxicity occurs in different percentages patients after treatment with platinum-based chemotherapy or cranial radiation therapy. The aim of this study was to present experience ototoxicity monitoring.
Carotid blowout syndrome (CBS) is defined as a rupture of common carotid artery or its branches. Endovascular intervention has been advocated first line treatment for CBS. This Case Report describes 5 patients with prior history head and neck cancer who presented Two acute, 2 impending, one threatened The lesions found were pseudoaneurysm focal vascular irregularities involving the artery, cervical internal lingual artery. Embolization occlusion detachable coils was used in all patients....
Ototoxicity occurs in different percentages patients after treatment with platinum-based chemotherapy or cranial radiation therapy. The aim of this study was to present our experience ototoxicity monitoring.A review made the registry paediatric cancer referred Children's Hearing Loss Unit from 1999 2019.Of 46 unit, 41 had received platinum as part their treatment, 17 underwent neurosurgery, and 18 An anamnesis otoscopy were performed on all them, monitoring carried out tone-verbal audiometry...
Activation of WNT/β-catenin signaling has been associated with a non-T-cell-inflamed tumor microenvironment (TME) in several cancers. The aim this work was to investigate the relationship between β-catenin and TME inflammation head neck squamous cell carcinomas (HNSCCs). Membrane nuclear expression, PD-L1 CD8+ tumor-infiltrating lymphocyte (TIL) density were jointly evaluated by immunohistochemistry series 372 HPV-negative HNSCCs. levels decreased compared normal epithelium. Positive...
ABSTRACT Introduction Cortactin (CTTN) and the Focal Adhesion Kinase (FAK) are two major candidate genes to respectively drive 11q13- 8q24-associated aggressive behaviour in various cancers. Recent evidence uncovered their clinical relevance early stages of tumorigenesis as promising biomarkers for cancer risk assessment. Material methods Using a multicenter validation study CTTN FAK expression was evaluated by immunohistochemistry cohort 109 patients with laryngeal precancerous lesions,...
El meningioma primario de la vaina del nervio óptico es un tumor raro, cuyo manejo diagnóstico y terapéutico ha variado manera sustancial en los últimos años.La aparición desarrollo las técnicas por imagen, como son Tomografía Computerizada Alta Resolución Resonancia Magnética Nuclear, han permitido diagnósticos más precoces precisos.La introducción Radioterapia Convencional (RT) a finales años 70, sola o combinación con cirugía, pero sobre todo Extereotáxica Fraccionada (RTEF)...
ICHNO International Congress on innovative approaches in Head and Neck Oncology (7th, 2019, Barcelona, Spain)