A5103042986- Antibiotic Resistance in Bacteria
- Cancer-related Molecular Pathways
- Antibiotics Pharmacokinetics and Efficacy
- Plant Molecular Biology Research
- Horticultural and Viticultural Research
- Bacterial Identification and Susceptibility Testing
- Plant Reproductive Biology
- Peptidase Inhibition and Analysis
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Light effects on plants
- Circadian rhythm and melatonin
- Ubiquitin and proteasome pathways
- Plant biochemistry and biosynthesis
Guangzhou Medical University
2023-2024
Guangzhou University of Chinese Medicine
2023
Soochow University
2018
The ubiquitin-proteasome system (UPS) modulates the ubiquitination and degradation of many proteins thus alters their abundance biological functions. core clock protein, aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL or BMAL1), is master regulator circadian plays important roles in regulation processes, such as synthesis, cell senescence, rhythms. However, influence UPS on BMAL1 not fully understood. Here, we find an E3 ubiquitin ligase, TNF receptor-associated factor 2...
As an important virulence phenotype of Escherichia coli, the regulation mechanism biofilm by non-coding RNA and quorum sensing system has not been clarified. Here, transcriptome sequencing RT-PCR analysis, we found CsrB, a carbon storage system, was positively regulated LuxR protein SdiA. Furthermore, β-galactosidase reporter assays showed that SdiA enhanced promoter transcriptional activity csrB. The consistent dynamic expression levels CsrB during coli growth were also detected. Moreover,...
Eravacycline (ERV) has emerged as a therapeutic option for the treatment of carbapenem-resistant pathogens. However, advent heteroresistance (HR) to ERV poses challenge these strategies. This study aimed investigate HR prevalence among common clinical isolates and further characterize in Klebsiella pneumoniae (CRKP). A total 280 pathogens from two centers were selected analyzed using population analysis profiling (PAP) modified E -tests. The PAP assay revealed an overall 0.7% (2/280), with...