Abstract Human herpesvirus-6 (HHV-6) is a member of the HHV family and rare cause infectious uveitis. We report case splenectomised patient, hospitalised due to invasive pneumococcal disease, who was diagnosed with retinitis in right eye, good visual acuity (0.1 LogMAR). Given presence HHV-6 Polymerase chain reaction (PCR) cerebrospinal fluid serum coexistence severe central nervous system infection, ophthalmological features were attributed infection. He treated topical corticosteroid...

Although classically classified as a non-inflammatory condition, an inflammatory basis for keratoconus (KC) appears to be growing evidence. Recently, it has been shown that KC patients have increased choroidal thickness (CT). Among disorders, atopy associated with development; therefore, the aim of this study was evaluate if CT in is related atopy.This analytical cross-sectional KC. Patients were atopic and non-atopic according their history (allergic rhinoconjunctivitis (AR), asthma (AA)...

Introduction: Mucopolysaccharidosis type VI (MPS VI) is a rare inherited metabolic disorder, primarily attributed to the deficiency of enzyme N-acetylgalactosamine-4-sulfatase, responsible for degradation dermatan sulfate and chondroitin-4-sulfate. Therefore, there widespread accumulation partially degraded glycosaminoglycans. Corneal opacification hallmark ocular feature in MPS. Retinal scleral involvement this MPS extremely rare. The purpose work was describe novel fundoscopic alterations...

Abstract: The pandemic caused by SARS-CoV-2 remains a health care concern, despite vaccination programs. Mucormycosis, especially rhino-orbital-mucormycosis, has been described as severe complication of COVID-19. Although it mostly in India and other developing countries, few cases the western world have also described. We present case rhino-orbito-mucormycosis after recovery from COVID-19 Portugal. A 75-year-old diabetic obese man presented with right proptosis associated eye pain low...

Purpose: This work aimed to longitudinally assess the peripapillary (PPCT) and subfoveal (SFCT) choroidal thickness (CT), in patients diagnosed with central (CRVO) or branch retinal vein occlusions (BRVO), correlating SFCT macular (CMT) PPCT nerve fiber layer (pRNFL). Patients Methods: was a retrospective longitudinal study of 71 eyes from treatment-naïve occlusion (24 CRVO 40 BRVO). Spectral-domain optical coherence tomography (SD-OCT, Spectralis HRA-OCT, Heidelberg) used measure PPCT,...

Thyroid eye disease (TED) characterizes by inflammation and remodeling of orbital tissues. Although the majority pediatric TED is mild, some children present progressive severe disease. The approach to in this group patients, especially when noncortico-responsive, challenging. purpose work was describe effective use tocilizumab as second-line therapy steroid-resistant TED. A 13-year-old female with a history Graves' presented right proptosis for at least 8 months associated mild pain on...

Mucopolysaccharidosis (MPS) VI is a rare genetic disease characterized by deficient activity of N-acetylgalactosamine 4-sulfatase, leading to the systemic deposition glycosaminoglycans. Ocular involvement classically progressive corneal clouding, ocular hypertension (OHT), and optic neuropathy. Although clouding can be solved with penetrating keratoplasty (PK), visual impairment usually remains, being frequently attributed glaucoma. The purpose this study was retrospectively describe series...

Objectivo: estudar determinantes cardiovasculares condicionantes do tempo de ventilação, mortalidade e gravidade doença em doentes admitidos numa unidade cuidados intensivos para ventilação mecânica por exacerbação insuficiência respiratória crónica. Desenho local: Estudo prospectivo, com duração 30 meses médico-cirúrgica 14 camas. Material métodos: Estudados 59 idade média 74,7 +/- 9,7 anos, médio 10,8 12,6 dias, APACHE II 23 8,3. Avaliaram-se parâmetros ecocardiográficos (dimensões das...

Background: Leber hereditary optic neuropathy (LHON) is an of mitochondrial inheritance. Childhood-onset disease relatively rare and there are limited data on this important patient subgroup. Case Presentation: We present 3 particular presentations LHON. Patient 1 was 8-year-old boy admitted to the emergency department reporting a progressive bilateral visual loss intermittent headaches. Neuro-ophthalmological examination revealed pseudopapilledema. Lumbar puncture identified intracranial...

Background Oculofaciocardiodental (OFCD) syndrome is a rare genetic disorder affecting ocular, facial, dental, and cardiac systems, being an X-linked condition caused by pathogenic variants in the BCL-6 corepressor gene ( BCOR). We report case series of three female patients with OFCD severe glaucoma. Results Three different involving BCOR gene, heterozygosity: seven-years-old girl insertion (c.2037_2038dupCT), nine years-old microdeletion X (p21.2-p11.4)) spanning gene; 25 deletion...

Purpose The purpose of this work is to investigate the effect ghrelin in a primate choroid retinal cell line cultured under hyperglycemic conditions and its on early changes diabetic retinopathy an animal model type1 diabetes mellitus (DM1). Methods A RF/6a was used vitro assay. Cell migration assessed using wound healing assay increasing (0-300mM) glucose concentrations. To test effect, added (10-5-10-10nM) cultures for 24h. Positive controls had VEGF medium. For vivo studies, Wistar rats...

Purpose Ghrelin is a peptide expressed in many organs and tissues. Recently, ghrelin has been implicated the pathophysiology of proliferative retinopathy, although its true involvement remains unclear. The aim this study to test effect migration, proliferation, apoptosis vitro angiogenesis primate choroid retinal endothelial cells (RF/6A), cultured under high glucose conditions. Methods RF/6A were incubated for 24 hours with different concentrations (0-300 mM). Cell migration was assessed...

In Brief We read with interest the article entitled “Risk of exudative age-related macular degeneration in patients central serous chorioretinopathy: A Nationwide Cohort Study” recently published Retina Journal. However, we believe that authors failed to define AMD and differentiate it from choroidal neovascularization complicating CSC (i.e., pachychoroid neovasculopathy).

Purpose: The purpose of this study was to describe an atypical and severe case giant cell arteritis (GCA). Methods: This a report description. Results: authors the 76-year-old man who presented with progressive bilateral visual loss. On presentation at ophthalmology emergency room, patient's right eye (OD) displayed aqueous flare, hyphema, rubeosis iridis , dense posterior capsular opacification. After YAG laser capsulotomy, vitreous densifications, intraretinal hemorrhages, cotton wool...

Abstract Purpose: To evaluate choroidal thickness progression over time in patients with exudative age‐related macular degeneration (AMD) and its relation anti‐VEGF treatment. Methods: Retrospective observational case series. Study group included observed between January 2022 April at Ophthalmology Department of Hospital de São João, Porto, Portugal, diagnosed bilateral AMD (eAMD) or unilateral eAMD intermediate (iAMD) contralateral eye a minimum follow up 2 years. Subfoveal was measured...