A5034051447- Diet and metabolism studies
- Diabetes Treatment and Management
- Advanced Glycation End Products research
- Bariatric Surgery and Outcomes
- Pharmacology and Obesity Treatment
- Natural Antidiabetic Agents Studies
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Biochemical and biochemical processes
- T-cell and B-cell Immunology
- Biomedical Research and Pathophysiology
- Occupational and environmental lung diseases
- Alcohol Consumption and Health Effects
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Lipid metabolism and biosynthesis
- Trace Elements in Health
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular and exercise physiology
- Ovarian function and disorders
- Immune Cell Function and Interaction
- Selenium in Biological Systems
German Cancer Research Center
2016-2023
Heidelberg University
2013-2023
University Hospital Heidelberg
2013-2023
Chirurgische Universitätsklinik Heidelberg
2018
Helmholtz Zentrum München
2018
German Center for Diabetes Research
2018
Heinrich Heine University Düsseldorf
2018
Deutsches Diabetes-Zentrum e.V.
2018
Abstract Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites sensed by the human body and not. We previously showed that fatty acid stearic (C18:0) signals via a dedicated pathway regulate mitofusin activity thereby mitochondrial morphology function cell culture. Whether this poised sense changes dietary intake of C18:0 humans not known. show here ingestion rapidly robustly causes fusion people within 3 h after ingestion. also...
Abstract The suppressor function of regulatory T cells (Tregs) is impaired in multiple sclerosis (MS), but the mechanisms underlying this deficiency are not fully understood. As Tregs counteract sustained elevation intracellular calcium, which indispensable for full activation conventional (Tcons), we hypothesized that interference with pathway might prompt MS-related Treg dysfunction. Using single-cell live imaging, observed rapidly reduce Ca2+ influx and downstream signals Tcons upon cell...
Methylglyoxal (MG) is a reactive metabolite that forms adducts on cysteine, lysine and arginine residues of proteins, thereby affecting their function. detoxified by the Glyoxalase system, consisting two enzymes, Glo1 Glo2, act sequentially to convert MG into d-lactate. Recently, Parkinsonism-associated protein DJ-1 was described in vitro have glyoxalase activity, detoxifying metabolite, or deglycase removing adduct formed proteins. Since Drosophila an established model system study...
Methylglyoxal (MG) is a highly reactive α-oxoaldehyde that glycates proteins. MG has been linked to the development of diabetic complications: major precursor advanced glycation end products (AGEs), risk marker for complications in humans. Furthermore, flies and fish with elevated develop insulin resistance, obesity, hyperglycemia. detoxified large part through glyoxalase system, whose rate-limiting enzyme I (Glo1). Hence, we aimed study how Glo1 activity regulated. We studied regulation...
Exercise and increased physical activity are vital components of the standard treatment guidelines for many chronic diseases such as diabetes, obesity cardiovascular disease. Although strenuous exercise cannot be recommended to people with numerous conditions, walking is something most can perform. In comparison high-intensity training, metabolic consequences low-intensity have been less well studied. We present here a feasibility study subject who performed an intervention low-intensity,...