A5000781509- Neonatal and fetal brain pathology
- Prenatal Substance Exposure Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Fatty Acid Research and Health
- Fetal and Pediatric Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Spinal Dysraphism and Malformations
- Muscle Physiology and Disorders
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
University of Maryland, Baltimore
2016-2024
Advanced Imaging Research (United States)
2019-2024
Perinatal hypoxia ischemia (HI) is a significant cause of brain injury in surviving infants. Although hypothermia improves outcomes some infants, additional therapies are needed since about 40% infants still have poor outcome. Acetyl-<smlcap>L</smlcap>-carnitine (ALCAR), an acetylated derivative <smlcap>L</smlcap>-carnitine, protected against early changes metabolites and mitochondrial function after HI on postnatal day (PND) 7 rat pup model near-term injury. However,...
A murine model of central nervous system (CNS) decompression sickness demonstrates that high gas pressure activates astrocytes and microglia triggering inflammatory microparticle (MP) production. Thrombospondin-expressing MPs are released from the CNS via enhanced glymphatic flow to systemic circulation where they activate neutrophils. Secondary production neutrophil-derived causes further cell activation neutrophil adherence brain microvasculature establishing a feed-forward neuroinflammatory cycle.
Blast-related traumatic brain injury (bTBI) is a major cause of neurological disorders in the U.S. military that can adversely impact some civilian populations as well and lead to lifelong deficits diminished quality life. Among these types injuries, long-term sequelae are poorly understood because variability intensity number blast exposure, range subsequent symptoms overlap with those resulting from other events (e.g., post-traumatic stress disorder). Despite valuable insights rodent...
Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans rats. Behavioral changes include deficits executive function, which requires cooperative activity between the frontal cortices other regions. In this study, we analyzed connectivity neurochemical levels of prefrontal cortex (PFC) using resting-state magnetic resonance imaging (rsfMRI) proton spectroscopy (<sup>1</sup>H-MRS) ethanol-exposed (Eth) control (Ctr) Pregnant Long-Evans rats...
Fetal alcohol spectrum disorder (FASD) is the leading known cause of intellectual disability, and may manifest as deficits in cognitive function, including working memory. Working memory capacity accuracy increases during adolescence when neurons prefrontal cortex undergo refinement. Rats exposed to low doses ethanol prenatally show adolescence, flexibility young adulthood. The cholinergic system plays a crucial role learning processes. Here we report that combination choline training on...
Mild (mTBI) traumatic brain injury (TBI) accounts for the majority of all TBI cases. Evidence has suggested that patients with mTBI can suffer from long-lasting cognitive deficits, persistent symptoms, and decreased quality life. Sleep disorders are commonly observed after TBI, prevalence rate sleep disturbances in persons being much higher than general population. Poor impair functions This effect may impede recovery processes population TBI. The objective this study is to add our...
Children with fetal alcohol spectrum disorders (FASD) often have deficits associated multisensory processing. Because ethanol (EtOH) disrupts activity-dependent neuronal plasticity, a process that is essential for refining connections during cortical development, we hypothesize early exposure results in alterations networks, which could explain the processing seen FASD. Here, use gyrencephalic animal model to test prediction alters functional connectivity and microstructural features of...
Blast-related traumatic brain injury (bTBI) resulting from improvised explosive devices is the hallmark of recent wars, and affects many returning veterans who experienced either direct or indirect exposure. Many these have long-term neurocognitive symptoms. However, there very little evidence to show whether blast-induced acceleration alone, in absence secondary impacts, can cause mild TBI. In this study, we examine effect under-vehicle hyperacceleration (uBIH) ∼1700 g on biochemical...
MET, the gene encoding tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility autism spectrum disorder (ASD). Genetically altered mice with kinase-inactive Met offer potential model understanding neural circuit organization changes in autism. Here, we focus on somatosensory thalamocortical circuitry because distinct sensitivity phenotypes accompany ASD, and this system plays major role sensorimotor social behaviors mice. We employed resting-state functional magnetic...
People with fetal alcohol spectrum disorder (FASD) often have structural or functional alterations of the central nervous system, including changes in brain network organization. These been associated neuropsychological deficits, but outcomes are not consistent across studies. We used a rat model FASD to assess males and females following ethanol exposure during prenatal period similar first half gestation humans.
Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by the lack of dystrophin with progressive degeneration skeletal muscles. Most studies regarding DMD understandably focus on muscle, but also expressed in central nervous system, potentially resulting cognitive and behavioral changes. Animal models are being used for developing more comprehensive neuromonitoring protocols clinical image acquisition procedures. The recently developed rat animal model that parallels muscle...
Compared to rodents, the ferret model has greater similarities humans in terms of developmental process, brain structure and sophisticated behavior. In this study, we assessed longitudinal changes metabolism impulsivity behavior a that closely mimics blast exposure conditions encountered by Warfighters. Ferrets demonstrated concomitantly increased behavioral metabolite alterations prefrontal cortex following exposure. Our findings agree with clinical observations patients, suggesting is good...