A5057088265- Metal complexes synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- X-ray Diffraction in Crystallography
- Ferrocene Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Magnetism in coordination complexes
- Hemoglobin structure and function
- Nanoparticle-Based Drug Delivery
- Computational Drug Discovery Methods
- Synthesis of Tetrazole Derivatives
- Advanced Drug Delivery Systems
- Inorganic and Organometallic Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Photochemistry and Electron Transfer Studies
- Thermal and Kinetic Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Radioactive element chemistry and processing
- Click Chemistry and Applications
University of Kragujevac
2012-2025
Lurasidone (LUR) is an antipsychotic drug whose interaction with human serum albumin (HSA) plays a crucial role in its pharmacokinetic and pharmacodynamic properties. A thorough understanding of LUR’s binding mechanism to HSA for predicting transport, distribution, potential interactions. Methods: The between LUR was investigated using fluorescence circular dichroism (CD) spectroscopy, followed by molecular docking simulations. Binding characteristics were analyzed through quenching...
The synthesis and characterization of novel hetrometallic complexes [{ cis ‐PtCl(NH 3 ) 2 ( μ ‐4,4′‐bipyridyl)ZnCl(terpy‐Cl)}](ClO 4 C1a ), trans ‐4,4′‐bipyridyl)ZnCl(terpy)}](ClO C2a ‐pyrazine)ZnCl(terpy‐Cl)}](ClO C3a C4a (where terpy‐Cl = 4′‐chloro‐2,2′:6′,2′′‐terpyridine) was done. Acid–base titrations were performed by UV–Vis spectrophotometric method to evaluate the p K a values corresponding aqua complexes. Interactions between important biomolecules, guanosine‐5′‐monophosphate...
A series of mono- and heteronuclear platinum(II) zinc(II) complexes with 4,4′,4″-tri-tert-butyl-2,2′:6′,2″-terpyridine ligand were synthesized characterized. The DNA protein binding properties [ZnCl2(terpytBu)] (C1), [{cis-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C2), [{trans-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C3), [{cis-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C4) [{trans-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C5) (where terpytBu =...
Human serum albumin (HSA) has a very significant role in the transport of drugs, their pharmacokinetic and pharmacodynamic properties, as well unbound concentration drugs circulating plasma. The aim this study was to look into competition between tigecycline (TGC) alkaloid (ALK) (caffeine (CAF)), flavonoids (FLAVs) (catechin (CAT), quercetin (QUE), diosmin (DIO)) binding HSA simulated physiological conditions using multiple spectroscopic measurements docking simulations. Fluorescence...
Copper(II) complexes of hexadentate ethylenediaminetetracarboxylic acid type ligands H4eda3p and H4eddadp (H4eda3p = ethylenediamine-N-acetic-N,N′,N′-tri-3-propionic acid; ethylenediamine-N,N′-diacetic-N,N′-di-3-propionic acid) have been prepared. An octahedral trans(O6) geometry (two propionate coordinated in axial positions) has established crystallographically for the Ba[Cu(eda3p)]·8H2O compound, while Ba[Cu(eddadp)]·8H2O is proposed to adopt a trans(O5) acetates) on basis density...
A ligand field molecular mechanics (LFMM) force (FF) has been developed for d 9 copper(II) complexes of aminopolycarboxylate ligands. Training data were derived from density functional theory (DFT) geometry optimizations 14 comprising potentially hexadentate N 2 O 4 , tetrasubstituted ethylenediamine (ed), and propylenediamine cores with various combinations acetate propionate side arms. The FF was validated against 13 experimental structures X‐ray crystallography including donors where the...
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Bearing in mind that some palladium complexes showed good antitumor potential while exhibiting less kidney toxicity comparing to cisplatin, discover a new agents for chemotherapy with improved properties two novel palladium(II) [Pd (L)2] (3A and 3B) acyl pyruvates (O,O bidentate ligands) were synthesized characterized by spectral (UV-Vis, IR, NMR, ESI-MS) elemental analysis. The analyzed their cytotoxic on human cancer cell lines (HeLa MDA-MB 231) normal fibroblasts (MRC-5). Results complex...
Serum albumin is the major soluble protein in circulatory system of humans. The metabolism drugs, their distribution, free concentration, and efficacy depend on drug-serum interaction [1]. Accordingly, it important to study interactions drugs with serum albumin, which determines pharmacology pharmacodynamics drugs. Quercetin (QUE), a natural polyphenol widely distributed many plant foods, such as fruits, vegetables, nuts, seeds, grains, tea [2], bind [3]. Tigecycline (TGC), tetracycline...
The synthesis and characterization of a newly synthesized piano-stool [Ru-(ɳ6-p-cymene)Cl2L] complex with ligand 3-amino-2-cyano-N-phenyl-3-(4-phenyl-1-piperazinyl)-2-propenethioamide are presented. was obtained in good yield as an ochre powderand characterized by elemental analysis, 1H 13C NMR, IR, conductometry, melting point. fluorescence binding studies showed that the interaction albumin occurs static quenching mechanism very high value constant one site (Kb = 1.68 × 107; n 1.37). In...
Human serum albumin (HSA) is a protein which makes up to 60% of the human plasma and as such most common in circulation. The synthetized liver possesses an array functions, main function being reversibly bind huge number compounds thereby acting transporter. binding increases solubility helps its distribution, except when affinity very high case larger dosses are needed achieve desired effect. Linamarin (2-β-D-glucopyranosyloxy-2-methylpropanenitrile) cyanogenic glucoside found Cassava,...
Tigecycline (TGC) is a new intravenous antibiotic with broad-spectrum effect against many drug-resistant organisms. Further, TGC class representer of antibacterial agents, named glycylcyclines. This group has been specifically developed to overcome the two major mechanisms tetracycline resistance: ribosomal protection and efflux. Flavonoids are wide natural compounds belonging secondary metabolites. Diosmin (main flavonoid in citrus juices) one most utilized being active principle drugs...
Human serum albumin (HSA) is a protein with major role in the transportation and deposition of many ligands present blood. Many papers science field deal interaction between drugs HSA because those mechanisms are very important for understanding pharmacokinetics pharmacodynamics drug pathways. Further, food components (such as flavonoids) may influence drug-HSA binding. It known that flavonoids polyphenolic secondary plant metabolites, which common fruits vegetables. Catechins one such...