Abstract Poly(vinylidene fluoride) (PVDF)‐based polymers demonstrate great potential for applications in flexible and wearable electronics but show low piezoelectric coefficients (e.g., − d 33 < 30 pC N −1 ). The effective improvement the piezoelectricity of PVDF is achieved by manipulating its semicrystalline structures. However, there still a debate about which component primary contributor to piezoelectricity. Therefore, current methods improve can be classified into modulations...

Deposition of collagen IV in proximal tubule cells (PTCs) plays an important role during diabetic nephropathy, but the mechanism underlying excessive production remains poorly understood. In this study, we examined miRNA profile HK‐2 and found that high glucose/TGF‐β1 induced significant down‐regulation miR‐29a. We then showed miR‐29a negatively regulated by directly targeting 3′UTRs col4a1 col4a2 . These results suggest acts as a repressor to fine‐tune expression reduction caused glucose...

Abstract Tumour vasculature is generally disordered because of the production excessive angiogenic factors by tumour cells, which results in progression and reduces effectiveness radiotherapy or chemotherapy. Transient anti-angiogenic therapies that regulate vascular morphology function improve efficiency antitumour therapy are under investigation. Recombinant human endostatin (Endostar/rhES) a angiogenesis–disrupting agent has been used to treat non-small cell lung cancer (NSCLC) clinical...

The early stages of angiogenesis can be divided into three steps: endothelial cell proliferation, migration, and tube formation. Vascular growth factor (VEGF) is considered the most important proangiogenic factor; in particular, VEGF 165 plays a critical role angiogenesis. Here, we evaluated whether gold nanoparticles (AuNPs) could inhibit -induced human umbilical vein (HUVEC) migration AuNPs were coincubated overnight at 4°C, after which effects on formation assessed. Cell was assessed...

Abstract: Angiogenesis is a process by which vessels are formed through preexisting ones, and this plays key role in the progression of solid tumors. However, tumor influenced excessive pro-angiogenic factors, resulting deformed structures that facilitate intravasation cells into circulation subsequent metastasis. Moreover, abnormal have low blood perfusion thereby decreased oxygen infusion This results hostile microenvironment promotes epithelial–mesenchymal transition (EMT), epithelial...

Abstract As a common anticancer drug, cisplatin has been widely used for treating tumors in the clinic. However, its side effects, especially nephrotoxicity, noticeably restrict application of cisplatin. Therefore, it is imperative to investigate mechanism renal injury and explore corresponding remedies. In this study, we showed phenotypes tubules epithelial cell death as well elevated cleaved-caspase3- TUNEL-positive cells rats intraperitoneally injected with Similar cisplatin-induced...

Abstract Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, microenvironment bone was exploited to develop multifunctional nanocarrier capable and promoting regeneration. The avidin-modified black phosphorus nanosheets (BP-Avidin, BP Avi ) were combined with biotin-modified Icaritin (ICT-Biotin, ICT Bio synthesize (ICT)-loaded (BP ). then coated macrophage...

The inhibition of the binding between VEGFs and their receptors reduces angiogenesis retards tumor growth. Owing to large amount antibodies required, antibody-based anti-angiogenic drug remains limited. Gold nanoparticles (AuNPs) displayed excellent biocompatibility, low toxicity effect, but mechanism anti-angiogenesis was unknown. Here, antitumor effects a well-dispersed AuNPs, specifically regarding its influence on VEGF signaling, were examined mechanistically. AuNPs interaction with...

Endothelial cell injury is an essential component of atherosclerosis and hypertension. Atherosclerosis other macrovascular diseases are the most common complications diabetes. Vaccarin a major flavonoid glycoside in Vaccariae semen, expected to be useful treatment vascular diseases. The aim present study was evaluate possible effects vaccarin human umbilical vein endothelial cells (EA.hy926) induced by hydrogen peroxide (H2O2) its underlying mechanism prevention H2O2 injury. In this study,...

Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also have been recognized. Hence, the present study was designed to explore whether Sirt1/PGC-1α participates protection exogenous postconditioning isolated rat hearts. Isolated hearts were...

Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of showed remarkable in vitro antiproliferative activities against GRC-1 and HepG2 cell lines. The first total synthesis peptide achieved for further biological evaluation.

Development of human embryonic stem cell (hESC)-based therapy requires derivation in vitro expandable populations that can readily differentiate to specified types and engraft upon transplantation. Here, we report hESCs into skeletal muscle cells without genetic manipulation. This is achieved through the isolation expressing a mesodermal marker, platelet-derived growth factor receptor-α (PDGFRA), following embryoid body (EB) formation. The ESC-derived differentiated myoblasts as evident by...

The ability of human embryonic stem cells (hESCs) to differentiate into skeletal muscle is an important criterion in using them as a cell source ameliorate impairments. However, differentiation hESCs still remains challenge, often requiring introduction transgenes. Here, we describe the use WNT3A protein promote vitro myogenic commitment hESC-derived and their subsequent vivo function. Our findings show that presence culture medium significantly promotes progenitors expressing mesodermal...

Transforming growth factor β1 (TGF-β1) has been associated with poor outcomes in patients breast cancer. However, the functions and underlying molecular mechanisms of TGF-β1 cancer remain unknown. Therefore, present study aimed to identify effects components TGF-β/microRNA (miR-)21/phosphatase tensin homolog (PTEN) signaling axis was identified upregulate expression miR-21, miR-21 demonstrated be significantly upregulated tissues compared benign proliferative disease. In addition, increased...

ABSTRACT Endometriosis (EM) and adenomyosis (AM) are interrelated gynecological disorders characterized by the aberrant presence of endometrial tissue frequently linked with chronic pelvic pain infertility, yet their pathogenetic mechanisms remain largely unclear. In this cross-sectional study, we analyzed samples from 244 participants, split into 91 EM patients, 56 AM 97 healthy controls (HC). We conducted untargeted liquid chromatography-mass spectrometry (LC-MS) 5R 16S rRNA sequencing to...

AIM:To study the correlation between high metastasisassociated protein 1 (MTA1) expression and lymphangiogenesis in colorectal cancer (CRC) its role production of vascular endothelial growth factor-C(VEGF-C). METHODS:Impact MTA1 VEGF-C levels on disease progression lymphovascular density (LVD, D2-40-immunolabeled) 81 cases human CRC was evaluated by immunohistochemistry. mRNA expressions LoVo HCT116 cell lines were detected real-time polymerase chain reaction Western blotting, respectively,...

Some chemotherapeutics have been shown to induce both the release of damage-associated molecular patterns (DAMPs) and production type I interferon (IFN-I), leading immunogenic cell death (ICD). However, standard chemotherapy drug for glioma, temozolomide (TMZ), cannot ICD as it activate IFN-I signaling. Moreover, inefficient delivery immunostimulants across blood-brain barrier (BBB) is main obstacle overcome in order local immune responses brain.

Dried stem bark from Albizia julibrissin (AJ) is a highly valued Traditional Chinese Medicine, which has been shown to suppress tumor growth and angiogenesis. Total saponins AJ (TSAJ) are one of the most bioactive components extract. The present study evaluated anti‑tumor anti‑angiogenic effects TSAJ in vitro vivo. activity was investigated by measuring on vascular endothelial factor (VEGF)‑induced proliferation, migration tube formation Ea.hy926 cells vitro. expression levels proteins...

Angiogenesis is a major pathological component of several diseases, including traumatic vascular disease and coronary heart disease.The purpose the present study was to determine effects vaccarin on endothelial cell migration neovascularization, which are important necessary components wound healing.The investigated confirmed neovascularization induced by in vitro vivo.In vitro, (1.08 2.15 µM) proliferation, tube formation human microvascular cells (HMEC)-1 were evaluated via sulforhodamine...