A5025825194- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Chromium effects and bioremediation
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Clinical Nutrition and Gastroenterology
- Microbial bioremediation and biosurfactants
- Hematopoietic Stem Cell Transplantation
- Isotope Analysis in Ecology
- Wastewater Treatment and Nitrogen Removal
- Clostridium difficile and Clostridium perfringens research
- Mesenchymal stem cell research
- Esophageal Cancer Research and Treatment
- Trace Elements in Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Soil and Water Nutrient Dynamics
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Bacteriophages and microbial interactions
- Marine and coastal ecosystems
- Cancer Cells and Metastasis
- Metal Extraction and Bioleaching
- Bird parasitology and diseases
- Coccidia and coccidiosis research
- Pharmaceutical and Antibiotic Environmental Impacts
University of Michigan
2017-2024
Michigan Medicine
2023
Bowling Green State University
2002-2016
University of Toledo
2003
The high susceptibility of neonates to infections has been assumed be due immaturity the immune system, but mechanism remains unclear. By colonizing adult germ-free mice with cecal contents neonatal and mice, we show that microbiota is unable prevent colonization by two bacterial pathogens cause mortality in neonates. lack resistance occurred when Clostridiales were absent microbiota. Administration Clostridiales, not Bacteroidales, protected from pathogen infection abrogated intestinal...
Hyporheic sediment bacterial communities were exposed to dissolved organic matter (DOM) from a variety of sources assess the interdependence metabolism and community composition. Experiments ranged small‐scale core perfusions with defined compounds (glucose, bovine serum albumin) mesocosms receiving natural leaf leachate or water different streams. Response variables included production, oxygen consumption, extracellular enzyme activity, similarity as manifest by changes in banding patterns...
Inhaled oxygen alters the microbiota of mice and humans, which may contribute to oxygen-induced lung injury.
niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Microbial communities must balance the assimilation of biologically necessary metals with resistance to toxic metal concentrations. To investigate impact heavy contaminants on microbial communities, we performed two experiments measuring extracellular enzyme activities (EEA) in polluted and unpolluted sediments Lake Erie. In first experiment, inoculations moderate concentrations copper zinc appreciably diminished EEA from uncontaminated sites, whereas contaminated increased or were only...
Key Points The presence of butyrogenic bacteria after the onset acute GVHD associates with subsequent steroid-refractory or chronic GVHD. Butyrate inhibits human colonic stem cells from forming an intact epithelial monolayer.
Pancreatic ductal adenocarcinoma has a unique tumor microbiome and the systemic depletion of bacteria or fungi using antibiotic/antifungal cocktails leads to decrease in pancreatic burden mice. However, functional studies remain rare due limited availability clinically relevant microbiota. Here, we describe detail isolation from small intestine cancer patients at Rogel Cancer Center. We then further characterized impact newly isolated
Abstract Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease conditions. Adherent–invasive Escherichia coli (AIEC), a pathobiont enriched the gut mucosa of patients with inflammatory bowel (IBD), utilizes diet-derived L-serine adapt inflamed gut. Therefore, restriction dietary starves AIEC and limits its fitness advantage. Here, we find that can overcome this nutrient limitation by switching source from diet host cells presence mucolytic bacteria....
Abstract Background Steroid refractory acute graft- vs. -host-disease (GVHD) after hematopoietic cell transplantation (HCT) is highly morbid with limited treatment options. Murine studies show protection from GVHD butyrate exposure but direct of stem/progenitor cells to inhibits colonic stem proliferation. Methods Stool samples were collected weekly in a cohort HCT recipients (n = 210) undergoing allogeneic transplant, and underwent 16S rRNA sequencing determine the number relative abundance...