A5082959301- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Boron and Carbon Nanomaterials Research
- Chemical Synthesis and Analysis
- Neuropeptides and Animal Physiology
- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
- Diabetes and associated disorders
- Erythrocyte Function and Pathophysiology
- Biocrusts and Microbial Ecology
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
University Hospital Carl Gustav Carus
2022
TU Dresden
2022
Leipzig University
2014-2020
Dexamethasone is widely used as an immunosuppressive therapy and recently COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested contribute diseases such acute kidney injury, myocardial infarction, stroke, all which are triggered by glutathione (GSH) depletion. GSH levels were significantly decreased dexamethasone. Mechanistically, identified up-regulated the metabolism regulating protein dipeptidase-1...
Abstract Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role pyroptosis is unclear. Pyroptosis mediated by pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern GSDMD-protein expression in peritubular compartment mice that underwent bilateral ischemia reperfusion (IRI). Along similar lines, whole lysates increased during first 84 h following cisplatin-induced AKI. Importantly, unlike...
G-protein-coupled receptors like the human Y1 receptor (hY1R) are promising targets in cancer therapy due to their high overexpression on cells and ability internalize together with bound ligand. This mechanism was exploited shuttle boron atoms into for application of neutron capture (BNCT), a noninvasive approach eliminate cells. A maximized number carboranes introduced hY1R-preferring ligand [F7,P34]-NPY by solid phase peptide synthesis. Branched conjugates loaded up 80 per molecule...
Boron neutron capture therapy (BNCT) allows the selective elimination of malignant tumor cells without affecting healthy tissue. Although this binary radiotherapy approach has been known for decades, BNCT failed to reach daily clinics date. One reasons is lack boron delivery agents. Using loaded peptide conjugates, which address G protein-coupled receptors overexpressed on allow intracellular accumulation boron. The gastrin-releasing receptor (GRPR) a well-known target in cancer diagnosis...
Boron-rich carboxylic acid derivatives were synthesised as coupling partners for tumour-selective biomolecules with applications selective BNCT agents.
The gastrin-releasing peptide receptor (GRPR) is part of the bombesin family and a well-known target in cancer diagnosis therapy. In last decade, promising results have been achieved by using peptide-drug conjugates, which allow selective targeting GRPR expressing tumor cells. Most ligands, however, antagonists even though agonists can lead to higher uptake owing their internalization. So far, only few studies focused on identification small GRPR-selective that are metabolically stable....
Introduction of a bis(isopropylidene)-protected galactopyranosyl moiety in s-triazine-based boron-rich carboxylic acids and amines results soluble suitable coupling partners for tumour-selective biomolecules with applications as selective agents boron neutron capture therapy (BNCT). Bearing either acid or primary amine functional group, these compounds are highly versatile thus largely extend the possible strategies biomolecules. Modification gastrin-releasing peptide receptor (GRPR) agonist...
G protein-coupled receptors (GPCRs) can be used to shuttle peptide-drug conjugates into cells. But, for efficient therapy, a high concentration of cargo needs delivered. To explore this, we studied the pharmacologically interesting neuropeptide Y1 receptor (Y1 R) in one recombinant and three oncogenic cell systems that endogenously express receptor. We demonstrate recycled behave identically newly synthesized with respect ligand binding internalization pathways. Depending on system,...
Diabetic nephropathy is the most common condition that requires a chronic renal replacement therapy, such as hemodialysis, peritoneal dialysis, kidney transplantation, or simultaneous kidney-pancreas transplantation. Chronic disease progression, loss of nephrons, which causes continuous decline eGFR, underlies pathogenesis diabetic nephropathy. During COVID-19 pandemic, it became clear amongst independent risk factors predicts unfavourable outcome upon SARS-CoV2 infection. While we still...