A5049403513- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Erythrocyte Function and Pathophysiology
- Cytomegalovirus and herpesvirus research
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- interferon and immune responses
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Phagocytosis and Immune Regulation
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
TU Dresden
2022-2024
University Hospital Carl Gustav Carus
2022-2024
Abstract Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role pyroptosis is unclear. Pyroptosis mediated by pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern GSDMD-protein expression in peritubular compartment mice that underwent bilateral ischemia reperfusion (IRI). Along similar lines, whole lysates increased during first 84 h following cisplatin-induced AKI. Importantly, unlike...
Small interfering RNAs (siRNAs) are widely used in biomedical research and clinical trials. Here, we demonstrate that siRNA treatment is commonly associated with significant sensitization to ferroptosis, independently of the target protein knockdown. Genetically targeting mitochondrial antiviral-signaling (MAVS) reversed siRNA-mediated sensitizing effect, but no activation canonical MAVS signaling, which involves phosphorylation IkBα interferon regulatory transcription factor 3 (IRF3), was...
Iridoviridae, such as the lymphocystis disease virus-1 (LCDV-1) and other viruses, encode viral insulin–like peptides (VILPs) which are capable of triggering insulin receptors (IRs) insulin-like growth factor receptors. The homology VILPs includes highly conserved disulfide bridges. However, binding affinities to IRs were reported be 200- 500-fold less effective compared endogenous ligands. We therefore speculated that these also have noninsulin functions. Here, we report LCDV-1 VILP can...
Diabetic nephropathy is the most common condition that requires a chronic renal replacement therapy, such as hemodialysis, peritoneal dialysis, kidney transplantation, or simultaneous kidney-pancreas transplantation. Chronic disease progression, loss of nephrons, which causes continuous decline eGFR, underlies pathogenesis diabetic nephropathy. During COVID-19 pandemic, it became clear amongst independent risk factors predicts unfavourable outcome upon SARS-CoV2 infection. While we still...
Abstract Background and Aims Contradicting previous reasoning, it is now established that necrotic rather than apoptotic cell death pathophysiologically drives acute tubular necrosis during AKI. Whereas involvement of necroptosis ferroptosis has been demonstrated by various groups, the role pyroptosis, a highly immunogenic form requiring proteolytic activation gasdermin protein family members, remains uncertain upon Thus, we aimed to investigate pyroptosis its mechanism action in Method We...
Abstract Acute kidney tubular necrosis (ATN) mediates acute injury (AKI) and nephron loss, the major risk factor for chronic disease (CKD) progression end-stage renal (ESRD) 1-3 . For decades, it has been known that female tissue is less sensitive to AKI 4,5 , but underlying mechanisms have remained elusive. As a specific feature, ATN characterized by dynamic cell death propagation along compartment, mediated ferroptosis in male mice 6,7 Herein we demonstrate ferroptotic abrogated tubules....
Abstract Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis contribute to acute kidney injury (AKI), but the role pyroptosis is unclear. Pyroptosis mediated by pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern GSDMD-protein expression in peritubular compartment mice that underwent bilateral ischemia reperfusion (IRI). Along similar lines, GSDMD whole lysates increased during first 84 hours following cisplatin-induced AKI. Importantly,...
Tonnus, Wulf; Maremonti, Francesca; Brucker, Anne M.; Linkermann, Andreas; AG Linkermann Author Information