A5091738414- Vector-borne infectious diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral Infections and Vectors
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Vector-Borne Animal Diseases
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Zoonotic diseases and public health
- Lymphoma Diagnosis and Treatment
- Dermatological diseases and infestations
- Chronic Lymphocytic Leukemia Research
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Virology and Viral Diseases
- Nail Diseases and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Maritime Navigation and Safety
- Bartonella species infections research
- Phytoplasmas and Hemiptera pathogens
- Climate Change and Health Impacts
- Global Public Health Policies and Epidemiology
- Hemoglobinopathies and Related Disorders
- CNS Lymphoma Diagnosis and Treatment
Karlstad Central Hospital
2021-2025
Center for Clinical Research (United States)
2025
Örebro University
2025
Center for Clinical Research Dalarna
2021-2023
Odense University Hospital
2014-2023
Statens Serum Institut
2017-2021
Rigshospitalet
2019
Slagelse Hospital
2018
Lac Courte Oreilles Ojibwa Community College
2017
University of Southern Denmark
2016
Although somatic mutations influence the pathogenesis, phenotype, and outcome of myeloproliferative neoplasms (MPNs), little is known about their impact on molecular response to cytoreductive treatment. We performed targeted next-generation sequencing (NGS) 202 pretreatment samples obtained from patients with MPN enrolled in DALIAH trial (A Study Low Dose Interferon Alpha Versus Hydroxyurea Treatment Chronic Myeloid Neoplasms; #NCT01387763), a randomized controlled phase 3 clinical trial,...
ABSTRACT Background Capnocytophaga canimorsus , a Gram-negative rod found in the commensal oral microflora of dogs, is rare cause infection following dog bite, with severe infections more commonly occurring asplenic or immunocompromised patients. This case septic shock and meningitis serovar B strain an immunocompetent patient who passed away due to infection. Case Summary A previously healthy man his late 50s no known immunodeficiencies was admitted hospital fever cognitive deficits after...
The number of hematological malignancies is expected to increase as the Danish population ages within next few decades. Despite this, data on course cancers among oldest patients are sparse with many intervention studies focusing younger age groups. aim this study present incidence and mortality rates older non-Hodgkin lymphomas (NHL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), acute myeloid (AML).Nationwide population-based presenting incidence, prevalence NHL, MM, AML a...
Lyme borreliosis (LB) is the most common tick-transmitted infection in northern hemisphere and caused by bacteria Borrelia burgdorferi sensu lato (Bbsl)-complex. The diagnosis partially based on serology, clinicians often take follow-up serum samples to look for seroconversion or an increase IgG-antibody levels. In this registry-based study, we proposed a method determining actual changes IgG examined antibody reactivity decay.Serological data from departments of clinical microbiology at...
Despite the presence of several microorganisms, other than Borrelia burgdorferi sensu lato (Bbsl) and TBE virus, in Ixodes ricinus ticks from Nordic countries, data is lacking on their pathogenic potential humans. In this study, we wanted to investigate aetiology clinical manifestations tick-transmitted infections individuals seeking medical care following a tick-bite. The sampling frame was participants large-scale, prospective, multi-centre, follow-up study tick-bitten volunteers recruited...
The tick-borne bacterium, Neoehrlichia mikurensis (N. mikurensis) can cause severe febrile illness and thromboembolic complications in immunocompromised individuals. We investigated the presence of N. DNA retrospectively collected plasma from a well-characterized cohort Danish patients.Plasma samples 239 patients with immune dysfunction related to hematological or rheumatological disease due immunosuppressive therapy, were retrieved transdisciplinary biobank (PERSIMUNE) at Rigshospitalet,...
(Bbsl) and tick-borne encephalitis virus (TBEV) are pathogens. This study aimed to investigate the seroprevalence of these pathogens in Danish blood donors.
With a prevalence of 4.7–13% in Danish Ixodes ricinus ticks, Rickettsia helvetica is one the most frequently detected tick-borne organisms Denmark. Most reports human exposure have described asymptomatic seroconversion or mild, self-limiting flu-like illness but it has also been implicated as cause subacute lymphocytic meningitis. Because Borrelia burgdorferi sensu lato (Bbsl) and R. are both found same tick species, potential co-transmission possibility. We examined 1) seroprevalence...
Abstract Tick-borne encephalitis (TBE) is a tick-borne infection with an increasing presence in many European countries. It caused by the TBE virus (TBEV), flavivirus transmitted Ixodes ricinus tick northern Europe. In Denmark, exists endemically on island of Bornholm. However, large proportion Danish cases are also imported from Sweden, where incidence has steadily been during last few decades. With prospect expanding risk areas due to climate change, surveillance data exchange between...
A 33-year-old man treated with azathioprine for 12 years Crohn’s disease presented headache, nausea and vomiting accompanied by difficulty in putting words together slight mental confusion. Prednisolone antibiotics were without effect. MRI of the brain showed multiple focal lesions surrounding oedema. There was cerebrospinal fluid pleocytosis, Epstein-Barr virus (EBV) DNA detected spinal PCR. biopsy confirmed suspicion primary lymphoma. EBV-associated lymphoma is a relevant differential...
Rickettsia spp. can be found across the globe and cause disease of varying clinical severity, ranging from life-threatening infections with widespread vasculitis to milder, more localized presentations. Vector and, some degree, reservoir are hematophagous arthropods, most species harboured by ticks. In Denmark, rickettsiae known as a imported travel-related infections, but also endemically in ticks country. Data are, however, lacking on geographical origin features diagnosed cases. this...
Erythema migrans (EM) is the most common manifestation of Lyme borreliosis. Here, we examined EM patients in Norwegian general practice to find proportion exposed tick-transmitted microorganisms other than Borrelia, and impact co-infection on clinical manifestations disease duration.Skin biopsies from 139/188 were analyzed using PCR for Neoehrlichia mikurensis, Rickettsia spp., Anaplasma phagocytophilum Babesia spp. Follow-up sera 135/188 spotted fever group (SFG) Rickettsia, A. microti...
Background: Hydroxyurea (HU) is used as first‐line cytoreductive therapy for patients with myeloproliferative neoplasms (MPNs) in most parts of the world. Recent studies have provided encouraging results treatment MPN off‐label recombinant interferon alpha‐2 (r‐IFNα) compared HU. However, direct comparison HU r‐IFNα not been conducted. Aims: To investigate efficacy and toxicity low‐dose vs. MPN. Methods: The DALIAH trial an ongoing investigator initiated Danish multicenter randomized...