A5089050711- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cystic Fibrosis Research Advances
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Antibiotics Pharmacokinetics and Efficacy
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- Infections and bacterial resistance
- Hematological disorders and diagnostics
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Pharmaceutical studies and practices
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Bacterial biofilms and quorum sensing
- Vector-borne infectious diseases
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Membrane Separation Technologies
- Cell death mechanisms and regulation
- Antibiotic Resistance in Bacteria
Zealand University Hospital
2021-2025
Zealand University Hospital Køge
2025
Roskilde Sygehus
2025
Region Zealand
2021-2024
Statens Serum Institut
2021-2024
University of Copenhagen
2010-2022
Harvard University
2022
Czech Academy of Sciences, Institute of Microbiology
2021
Rigshospitalet
2010-2016
Abstract The neutrophil-to-lymphocyte ratio(NLR) is increased in chronic inflammation and myeloproliferative neoplasms (MPN). We hypothesize that NLR associated with all-cause mortality by comorbidity burden the general population individuals MPN. included 835,430 from Danish General Suburban Population Study, practitioners, outpatient clinics. investigated on stratified prevalent incident MPN, essential thrombocythemia (ET), polycythemia vera (PV), myelofibrosis (MF), (CCI-score), Triple-A...
Anaplasmosis is caused by the tick-borne bacterium Anaplasma phagocytophilum. In this case report, a 73-year-old immunocompetent male was admitted with high fever, headache and fatigue following tick bite. The patient had hyperinflammation an intense 18F-fluordeoxyglucose uptake in spleen bone marrow. patient's symptoms subsided without specific treatment. A. phagocytophilum identified use of amplicon-based 16S/18S rDNA next generation-sequencing DNA extracted from ethylenediamine...
The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is impaired function unknown. In the Danish General Suburban Population Study (N = 19 958) from 2010 to 2013, 645 individuals were positive for JAK2V617F 613) or CALR 32) mutations. Mutation-positive without haematological malignancy defined as having CHIP 629). We used multiple and inverse probability weighted (IPW)-adjusted linear regression...
Essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF) are myeloproliferative neoplasms (MPN). Inflammation is involved in the initiation, progression, symptomology of diseases. The gut microbiota impacts immune system, infection control, steady-state hematopoiesis.
The Philadelphia chromosome-negative myeloproliferative neoplasms are a group of slowly progressing haematological malignancies primarily characterised by an overproduction myeloid blood cells. Patients treated with various drugs, including the JAK1/2 inhibitor ruxolitinib. Mathematical modelling can help propose and test hypotheses how treatment works. We present extension Cancitis model, which describes development their interactions inflammation, that explicitly models progenitor cells...
Summary Background: Ciprofloxacin (CIP) is frequently used when treating cystic fibrose (CF) patients with intermittent Pseudomonas aeruginosa (P. aeruginosa) lung colonization. However, approximately 20% of the progress to chronic infection despite early intervention. The aim this study, was investigate pharmacokinetics CIP, evaluate if CYP3A4‐related metabolism involved and find optimal dose needed eradicate intermittently colonizing bacteria in lungs CF patients. Methods An open‐label,...
Chronic inflammation is believed to play an important role in the development and disease progression of polycythemia vera (PV). Because association between gut microbiota, hematopoiesis, well established, we hypothesized that patients with PV have a microbiota distinct from healthy control participants (HCs). Recombinant interferon alfa 2 (IFN-α2)-treatment reportedly modifying terms normalization elevated blood cell counts concert reduction JAK2V617F allelic burden. Therefore, treated...
Initial diagnosis of overt myeloproliferative neoplasms (MPNs) represents the juncture during clonal evolution when symptoms or complications prompt an afflicted individual to seek medical attention. In 30-40% MPN subgroups essential thrombocythemia (ET) and myelofibrosis (MF), somatic mutations in calreticulin gene ( CALR ) are drivers disease resulting constitutive activation thrombopoietin receptor (MPL). current study, we describe a healthy mutated 12 year follow-up from initial...
Granulomas contain multinucleated giant cells (MGCs), the function of which remains largely unknown. In patients with autoimmune granulomatous disease, granulomas can be resolved during treatment glucocorticosteroid (GCS). However, little is known about influence GCSs on formation MGCs.Monocytes isolated from buffy coats were stimulated IFN-γ and Concanavalin A to form MGCs either in presence or absence TNF-α, methylprednisolone (MP), adalimumab human immunoglobulin G. The concentrations...
Clonal Hematopoiesis of Indeterminate Potential (CHIP) is associated with an increased risk cardiovascular diseases (CVD) and a precursor stage to the BCR-ABL negative chronic myeloproliferative neoplasms (MPNs). These are acquired stem cell neoplasms, arising due mutations in hematopoietic cell. The most prevalent JAK2V617F (JAK2) mutation, which potently generates reactive oxygen species (ROS), accordingly contributes greatly inflammatory state thrombosis MPNs. MPNs largely underdiagnosed...
ABSTRACT Essential thrombocythemia (ET) is part of the Philadelphia chromosome-negative myeloproliferative neoplasms. It characterized by an increased risk thromboembolic events and also to a certain degree hypermetabolic symptoms. The gut microbiota important initiator hematopoiesis regulation immune system, but in patients with ET, where inflammation hallmark disease, it vastly unexplored. In this study, we compared via amplicon-based 16S rRNA gene sequencing V3–V4 region 54 ET according...