A5085208428- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- Proteoglycans and glycosaminoglycans research
- Legume Nitrogen Fixing Symbiosis
- Cannabis and Cannabinoid Research
- Diet, Metabolism, and Disease
- Digestive system and related health
- X-ray Diffraction in Crystallography
- Pneumocystis jirovecii pneumonia detection and treatment
- GABA and Rice Research
- Monoclonal and Polyclonal Antibodies Research
- Synthetic Organic Chemistry Methods
- Trypanosoma species research and implications
- Polyamine Metabolism and Applications
- HIV/AIDS drug development and treatment
- Lipid Membrane Structure and Behavior
- Toxin Mechanisms and Immunotoxins
- Crystallization and Solubility Studies
- Tuberculosis Research and Epidemiology
- Probiotics and Fermented Foods
Scripps Research Institute
2023-2025
Genomics Research Center, Academia Sinica
2021-2022
Indian Institute of Integrative Medicine
2011-2022
Academia Sinica
2022
Academy of Scientific and Innovative Research
2014-2020
Council of Scientific and Industrial Research
2011
Complex-type N-glycans are structurally diverse molecules, responsible for many biological processes, yet the specific sequences of involved in recognition remain largely unknown. Despite recent development efficient chemoenzymatic approaches, it is still lacking a general approach to produce complex-type N-glycans. Here, we designed two common precursors equipped with orthogonal protecting groups antennary differentiation and selective glycan elongation. The N-acetyllactosamine (LacNAc)...
Here, we report a three-step concise and stereoselective synthesis route to one of the most important phytocannabinoids, namely, (−)-cannabidiol (-CBD), from inexpensive readily available starting material R-(+)-limonene. The involved diastereoselective bifunctionalization limonene, followed by effective elimination leading generation key chiral p-mentha-2,8-dien-1-ol. p-mentha-2,8-dien-1-ol on coupling with olivetol under silver catalysis provided regiospecific (−)-CBD, contrary reported...
Remdesivir, an inhibitor of RNA-dependent RNA polymerase developed by Gilead Sciences, has been used for the treatment COVID-19. The synthesis remdesivir is, however, challenging, and overall cost is relatively high. Particularly, stereoselective assembly P-chirogenic center requires recrystallization a 1:1 isomeric p-nitrophenylphosphoramidate mixture several times to obtain desired diastereoisomer (39%) further coupling with d-ribose-derived 5-alcohol. To address this problem, variety...
Abstract Free oligosaccharides are abundant macronutrients in milk and involved prebiotic functions antiadhesive binding of viruses pathogenic bacteria to colonocytes. Despite the importance these oligosaccharides, structural determination is challenging, oligosaccharide biosynthetic pathways remain unclear. Oligosaccharide structures conventionally determined using a combination chemical reactions, exoglycosidase digestion, nuclear magnetic resonance spectroscopy, mass spectrometry. Most...
A comprehensive structure–activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 chMC813-70 as a model.
First, total synthesis of the cell surface phospholipomannan anchor [β-Manp-(1 → 2)-β-Manp]n-(1 2)-β-Manp-(1 2)-α-Manp-1 P-(O 6)-α-Manp-(1 2)-Inositol-1-P-(O 1)-phytoceramide Candida albicans is reported. The target (PLM) poses synthetic challenges such as unusual kinetically controlled (1 2)-β-oligomannan domain, anomeric phosphodiester, and unique phytoceramide lipid tail linked to glycan through a phosphate group. PLM was accomplished using convergent block approach three main...
A series of oxo-phenylacetyl (OPAc)-protected saccharides, with divergent base sensitivity profiles against benzoyl (Bz) and acetyl (Ac) were synthesized, KHSO5/AcCl in methanol was identified as an easy, mild, selective, efficient deprotecting reagent for their removal the perspective carbohydrate synthesis. Timely monitoring AcCl supportive both sequential simultaneous OPAc, Bz, Ac. The salient feature our method is orthogonal stability different groups, its ease to generate valuable...
Dysregulation of amyloidogenic proteins and their abnormal processing deposition in tissues cause systemic localized amyloidosis. Formation amyloid β (Aβ) fibrils that deposit as plaques Alzheimer's disease (AD) brains is an earliest pathological hallmark. The polysulfated heparan sulfate (HS)/heparin (HP) one the non-protein components Aβ deposits not only modulates aggregation, but also acts a receptor for to mediate cytotoxicity. Interfering with interaction between HS/HP could be...
Free oligosaccharides are abundant macronutrients in milk and involved prebiotic functions antiadhesive binding of pathogenic bacteria to colonocytes. Despite the importance these oligosaccharides, structural determination is challenging, oligosaccharide biosynthetic pathways remain unclear. Oligosaccharide structures conventionally determined using a combination chemical reactions, exoglycosidase digestion, nuclear magnetic resonance spectroscopy, mass spectrometry. Most reported free...