A5032518738- Tuberculosis Research and Epidemiology
- Prenatal Substance Exposure Effects
- Adenosine and Purinergic Signaling
- bioluminescence and chemiluminescence research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Aldose Reductase and Taurine
- Cancer therapeutics and mechanisms
- Mycobacterium research and diagnosis
Pontifícia Universidade Católica do Rio Grande do Sul
2010-2021
Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in last year. Herein, series of 20 1H-indoles were synthesized and evaluated vitro inhibitors Mycobacterium tuberculosis (Mtb) growth. Furthermore, top hit compounds active against multidrug-resistant strains, without cross-resistance first-line drugs. Exposing HepG2 Vero cells to molecules for 72 h showed that one structures was devoid apparent toxicity. In addition, this...
Abstract Tuberculosis (TB) is an infectious disease caused mainly by Mycobacterium tuberculosis (Mtb) and responsible for millions of deaths. New Mtb strains resistant to TB drugs are emerging spreading. The first-line drug, isoniazid (INH), must be activated inside mycobacterial cells the catalase-peroxidase enzyme KatG exert its antimicrobial activity, mutations on katG gene a significant cause INH resistance in clinics. metal-containing compound IQG-607 analog developed inhibit target...