A5041118171- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Amino Acid Enzymes and Metabolism
- Antimicrobial Peptides and Activities
- Cancer, Hypoxia, and Metabolism
- Fungal and yeast genetics research
- Biochemical and Structural Characterization
- Toxin Mechanisms and Immunotoxins
- Allergic Rhinitis and Sensitization
- Genomics, phytochemicals, and oxidative stress
- Plant nutrient uptake and metabolism
- Folate and B Vitamins Research
- Food Allergy and Anaphylaxis Research
- Metabolomics and Mass Spectrometry Studies
- Transgenic Plants and Applications
- Tea Polyphenols and Effects
- Bacteriophages and microbial interactions
- Nitrogen and Sulfur Effects on Brassica
- Occupational exposure and asthma
- Chemical Reactions and Isotopes
Washington University in St. Louis
2019-2022
Donald Danforth Plant Science Center
2004-2013
Health First
2011
Purdue University West Lafayette
2004
Children's Hospital of Philadelphia
2004
Abstract Plant defensins are a family of small Cys-rich antifungal proteins that play important roles in plant defense against invading fungi. Structures several share Cys-stabilized α/β-motif. Structural determinants govern their activity and the mechanisms by which they inhibit fungal growth remain unclear. Alfalfa (Medicago sativa) seed defensin, MsDef1, strongly inhibits Fusarium graminearum vitro, its is markedly reduced presence Ca2+. By contrast, MtDef2 from Medicago truncatula,...
Insulin secretion by pancreatic beta-cells is stimulated glucose, amino acids, and other metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in this process. The importance of GDH was underscored features hyperinsulinemia/hyperammonemia syndrome, where dominant mutation causes the loss inhibition GTP ATP. Here we report effects green tea polyphenols on insulin secretion. Of four compounds tested, epigallocatechin gallate (EGCG) epicatechin were found...
The globally cultivated
Summary The corn smut fungus, Ustilago maydis , is a global pathogen responsible for extensive agricultural losses. Control of using traditional breeding has met with limited success because natural resistance to U. organ specific and involves numerous maize genes. Here, we present transgenic approach by constitutively expressing the Totivirus antifungal protein KP4, in maize. Transgenic plants expressed high levels KP4 no apparent negative impact on plant development displayed robust...
Glutamate dehydrogenase (GDH) is found in all organisms and catalyzes the oxidative deamination of glutamate to 2-oxoglutarate. While this enzyme does not exhibit allosteric regulation plants, bacteria, or fungi, its activity tightly controlled by a number compounds mammals. We have previously shown that plays an important role insulin homeostasis humans evolved concomitantly with 48-residue "antenna" structure. As here, antenna some first appears Ciliates. This primitive mediated fatty...
Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in insulin secretion by pancreatic β-cells. The most compelling evidence of this comes from features the hyperinsulism/hyperammonemia (HI/HA) syndrome where dominant mutation causes loss inhibition GTP, and studies that link leucine (and its analogue BCH) activation GDH stimulation secretion. This suggests may represent new novel drug target control variety disorders. Recently we demonstrated subset green tea polyphenols...
Abstract Many protein families have numerous members listed in databases as allergens; however, some allergen database entries, herein called “orphan allergens”, are of large which all other not allergens. These orphan allergens provide an opportunity to assess whether specific structural features render a allergenic. Three [ Cladosporium herbarum aldehyde dehydrogenase (ChALDH), Alternaria alternata ALDH (AaALDH), and C. mannitol (ChMDH)] were recombinantly produced purified for structure...