A5071892474- Exercise and Physiological Responses
- Hematological disorders and diagnostics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Body Composition Measurement Techniques
- Bioactive natural compounds
- Synthesis of Organic Compounds
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Vitamin C and Antioxidants Research
- Bioactive Compounds and Antitumor Agents
- Blood groups and transfusion
University of Tsukuba
2020-2024
Japan Sport Council
2020
Excess reactive oxygen species (ROS) produced during strong or unfamiliar exercise cause exercise-induced gastrointestinal syndrome (EIGS), leading to poor health and decreased performance. The application of conventional antioxidants can neither ameliorate EIGS nor improve performance because their rapid elimination severe side effects on the mitochondria. Hence, a self-assembling nanoparticle-type antioxidant (RNP
Abstract Although the adverse effects of excessively generated reactive oxygen species (ROS) on body during aerobic exercise have been debated, there are few reports remarkable application conventional antioxidants performance. The could not enhance performance due to their rapid excretion from and serious cellular respiratory system. In this study, impact original antioxidant self‐assembling nanoparticle, redox‐active nanoparticle (RNP), is investigated rats running experiments. With an...
α-Mangostin-rich extract (AME) shows promise as a functional ingredient for cancer chemotherapy. Here, we encapsulated AME in our originally designed antioxidant nanoparticles (NanoAOX) to increase its solubility and prevent oxidative degradation (AME@NanoAOX). In this study, two types of self-assembled polymers containing nitroxide radicals were engineered. These into nanoscale particles aqueous media, entrapping (abbreviated AME@NanoAOX(B) AME@NanoAOX(G)). formulations considerably...
Aims] Excessive amounts of reactive oxygen species (ROS) generated by exercise causes oxidative stress to the body, and decreases performance.Antioxidants can reduce ROS stress.So it is thought that antioxidants may improve performance, however, poorly effective because discharged quickly from body.Therefore, we designed an antioxidant nanoparticle (RNP) shows a long capacity in vivo.Herein, used RNP rats running model.[Methods] Male F344 were administered run 40 m/min on animal...
Aims] High-intensity exercise has been reported to inhibit gastrointestinal integrity and function, called exercise-induced syndrome (EIGS).Although conventional antioxidants are expected ameliorate the EIGS by suppressing intestinal inflammation, none have effective since not only metabolized excreted quickly, but it also side effects such as mitochondrial damage.We designed nanoparticle-type (RNP O ), which reduce adverse of retained selectively in tract after oral administration.We...