Non-small cell lung cancer is mostly recognized among other types of with a poor prognosis by cause chemotherapeutic resistance and increased metastasis. Luteolin has been found to decrease However, its underlying mechanisms remain unresolved. The objective this study was examine the effect (and mechanism) luteolin on migration invasion human non-small A549 cells.Cell viability investigated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Wound healing transwell assays...

Abstract This study investigated the production of Sangyod rice bran hydrolysate (SYRB) from rice, focusing on incubation times (1, 3, and 5 h) alcalase enzyme concentrations (0, 0.7, 1% v/v). The results demonstrated a concentration-dependent relationship: higher increased yield. Prolonged incubation, especially with alcalase, enhanced substrate breakdown, further increasing production. degree hydrolysis, reflecting peptide bond cleavage, depended both time concentration, emphasizing role...

Recently, seaweed extracts have been found to potential in skin benefits. This study, therefore, aimed explore phytochemical analysis, antimicrobial, antioxidant, and wound healing properties of brown Sargassum plagiophyllym ethanolic extract (SPEE) on human keratinocyte HaCaT cells the possible mechanism involved. Our results indicated that SPEE contained flavonoid, phenolic, carotenoid as major active constituents. The HPLC chromatogram revealed C-phycocyanin fucoidan presented SPEE....

This study aimed to explore the use of D-limonene and some vegetable oils with different amounts saturated unsaturated fatty acids as alternative green solvents for microwave-assisted extraction (MAE) cannabis (Cannabis sativa L.). A standardized extract was selected evaluate its potential a chemopreventive agent. Alternative solvents, powder-to-solvent ratios, irradiation cycles were determined optimize MAE conditions. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...

Hawm Gra Dang Ngah rice (HDNR) is a red variety cultivated in Thailand’s southern border region, yet its biological properties have not been extensively studied. This study investigates the effects of HDNR extracts on bioactive constituents, spectral fingerprints, and antioxidant capacities. We evaluated inhibitory aqueous (HDNR-W) ethanolic (HDNR-E) monoamine oxidase (MAO), α-glucosidase, HMG-CoA reductase activities, as well their cytotoxicity normal cancer cells. The results demonstrated...

Apium graveolens L. is a traditional Chinese medicine prescribed as treatment for hypertension, gout, and diabetes. This study aimed to determine the neuroprotective effects of A. extract against Parkinson's disease (PD) model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice. Male mice treated with MPTP were orally dosed daily 21 days. Behavioral tests, including rotarod apparatus, narrow beam test, drag grid walk swimming resting tremor evaluation, performed....

BACKGROUND/OBJECTIVES: Re-epithelialization has an important role in skin wound healing.Astaxanthin (ASX), a carotenoid found crustaceans including shrimp, crab, and salmon, been widely used for protection.Therefore, we investigated the effects of ASX on proliferation migration human keratinocyte cells explored mechanism associated with that migration.MATERIAL/METHOD: HaCaT were exposed to 0.25-1 μg/mL ASX.Proliferation keratinocytes was analyzed by using MTT assays flow...

Centella asiatica is widely considered the most important medicinal plant for treating and relieving skin diseases. Recently developed standardized extract of ECa 233 has demonstrated positive effects on wound healing incision burn in rats. However, knowledge associated with mechanism was scare. Therefore, this study aimed to investigate effect underlying molecular mechanisms migration a human keratinocyte cell line (HaCaT) using scratch assay. Formation filopodia, key protein as well...

Bioactivites of hydrolyzed collagen from defatted Seabass skin were enhanced <italic>via</italic> conjugation with epigallocatechin-gallate (EGCG) using free radical grafting method.

Apium graveolens Linn. (Apiaceae) is an indigenous plant of the North and South Americas, Southern Europe, Asia has been widely used as a food or traditional medicine for treatment inflammation arthritis. The purpose this study was to investigate antioxidant effects methanolic extract A. (AGE) against liver oxidative stress in adjuvant-induced arthritic rat model. AGE (250, 500, 1,000 ㎎/㎏) given orally 24 consecutive days after induction by injecting complete Freund’s adjuvant. Liver spleen...

Hydrolyzed collagen (HC) from sea bass skin prepared using papain and Alcalase had antioxidant potency could enhance MRC-5 cell proliferation lamellipodia formation. HC can be used as a nutraceutical or functional food ingredient.

Oxidative stress and inflammation play key roles in the pathophysiology of dyslipidemia, which are positive risks that increase atherosclerosis leading to important healthcare problems. Therefore, we aimed study antioxidant, anti-inflammatory, lipid-lowering effects jelly drink containing polyphenol-rich roselle calyces extract passion fruit juice with pulp concentrate (RP drink) comparison a placebo for 8 weeks. Forty-three adults dyslipidemia were randomly assigned into two groups: RP...

Passion fruit is a dietary plant with the protective proterties against many diseases such as cardiovascular diseases. The aim of this study was to explore biological properties (anti-oxidant, anti-inflammatory, anti-lipid, and vascular relaxation) P. edulis extracts obtained from seed (PSEE) (PFWE). Thin-layer chromatography (TLC) HPLC were used analyze phytochemical constituents in extracts. Antioxidant enzyme inhibition examined. Anti-inflammatory activities PFWE PSEE evaluated...

To elucidate the anxiolytic and free radical scavenging effect of methanolic extract Apium graveolens (A. graveolens) in adult C57BL/6 mice. Sixty male mice were divided into 6 groups: control, vehicle, positive control A. (125, 250 500 mg/kg). Different behavioral models elevated plus maze, open field, light/dark, hole-board pentobarbital-induced sleep used to assess anxiety-like behavior. Biochemical parameters including monoamine oxidase-A (MAO-A) activity, lipid peroxidation, %...

Background.Interleukin 18 (IL-18) is an inflammatory cytokine belonging to the interleukin 1 (IL-1) superfamily, and known for its role in anti-cancer activity by promoting type immune response, thus may be applied cancer immunotherapy.Our previous report has showed 16 times higher of engineered E6K+T63A IL-18 than native vitro.However, no data been acquired effect animal model. Objectives.To investigate as stimulant vivo. Material methods.Tumor-bearing mice were treated with or E6K once a...

Abstract BACKGROUND Stroke is a neurological disease caused by sudden disturbance of cerebral blood flow to the brain, leading loss brain function. Recently, accumulating lines evidence have suggested that dietary enrichment with nutritional antioxidants could reduce damage and improve cognitive In this study, we investigated possible protective effects Apium graveolens , medicinal plant putative neuroprotective activity, against oxidative‐stress‐related due inflammation induced focal...

Metformin has recently emerged as a key player in promotion of neuroblastoma differentiation and neurite outgrowth. However, molecular mechanisms how metformin promotes cellular have not yet been fully elucidated. In this study, we investigated cell differentiation, via an inhibition proliferation, by culturing SH-SY5Y cells with or without metformin. Pretreatment reactive oxygen species (ROS) scavenger, NAC, revealed that ROS plays crucial role induction differentiation. Cell was observed...