A5047571292- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- Peripheral Neuropathies and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Influenza Virus Research Studies
Genomics Research Center, Academia Sinica
2022-2024
A major challenge to end the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is develop a broadly protective vaccine that elicits long-term immunity. As key immunogen, viral surface spike (S) protein frequently mutated, and conserved epitopes are shielded glycans. Here, we revealed S glycosylation has site-differential effects on infectivity. We found generated lung epithelial cells glycoforms associated with increased Compared fully glycosylated protein,...
Abstract Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited upon natural infection and vaccination showed that they recognize an immunogenic patch on the internal surface core RBD, which faces inwards is hidden “down” state. These broadly neutralize wild type (Wuhan-Hu-1) SARS-CoV-2, Beta Delta variants some are effective other sarbecoviruses. observed continuum...
Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from vaccinated and infected individuals elucidate the mechanism of action broadly neutralizing antibodies dissect at epitope level. The breadth clonality anti-RBD B cell response varies among individuals. majority clones lose or exhibit reduced activities Beta, Delta, Omicron variants. Nevertheless, portion that develops after primary series...