A5028612209- Congenital heart defects research
- Cardiovascular Disease and Adiposity
- Fish Ecology and Management Studies
- Coronary Interventions and Diagnostics
- Genetic Neurodegenerative Diseases
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Issues in Pregnancy
- Photochromic and Fluorescence Chemistry
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Developmental Biology and Gene Regulation
- Caveolin-1 and cellular processes
- Atherosclerosis and Cardiovascular Diseases
- Zebrafish Biomedical Research Applications
Insigneo
2016-2019
Centre for Life
2019
University of Sheffield
2014-2019
Imperial College London
2016
University College London
2016
Atherosclerosis is initiated at branches and bends of arteries exposed to disturbed blood flow that generates low shear stress. This mechanical environment promotes lesions by inducing endothelial cell (EC) apoptosis dysfunction via mechanisms are incompletely understood. Although transcriptome-based studies have identified multiple shear-responsive genes, most them an unknown function. To address this, we investigated whether zebrafish embryos can be used for functional screening...
Atherosclerosis develops near branches and bends of arteries that are exposed to disturbed blood flow which exerts low wall shear stress (WSS). These mechanical conditions alter endothelial cells (EC) by priming them for inflammation inducing turnover. Homeobox (Hox) genes developmental involved in the patterning embryos along their anterior-posterior proximal-distal axes. Here we identified Hox regulated WSS investigated functions adult arteries.EC were isolated from inner (low WSS) outer...
<h3>Introduction</h3> Atherosclerosis, a disease of arteries that can cause heart attack and stroke, is influenced by local blood flow patterns which exert wall shear stress (WSS) on endothelial cells (EC). Low, oscillatory WSS (LWSS) promotes atherosclerosis inducing EC apoptosis activation, while high, unidirectional (HWSS) athero-protective. We recently used microarray technology coupled to computational fluid dynamics study the transcriptome at regions porcine aorta exposed LWSS or HWSS....
Purpose: Atherosclerosis, a disease of arteries that can cause heart attack and stroke, is influenced by local blood flow patterns which exert wall shear stress (WSS) on endothelial cells (EC). Low, oscillatory WSS promotes atherosclerosis inducing EC apoptosis activation, while high, unidirectional athero-protective. We recently used microarray technology coupled to computational fluid dynamics study the transcriptome at regions porcine aorta exposed low, or WSS. The revealed differential...
Introduction: Atherosclerosis is influenced by blood flow patterns which exert wall shear stress (WSS) on endothelial cells (EC). Low oscillatory WSS promotes atherosclerosis inducing EC apoptosis and activation, whereas high unidirectional protective. We used microarray technology coupled to computational fluid dynamics study the transcriptome of at regions porcine aorta exposed low, or high, WSS. The revealed differential expression multiple genes that co-ordinate embryonic development....
<h3>Abstract</h3> <h3>Background</h3> Trauma-related pathological dissociation is a multidimensional and disabling phenomenon that involves disruptions or discontinuities in psychological functioning. Despite its prevalence, personal societal burden, remains underappreciated clinical practice, it lacks synthesized neurobiological model could place context with other common psychiatric symptoms. To identify nuanced of dissociation, we examined the functional connectivity three core...
Atherosclerosis develops at branches and bends of arteries that are exposed to disturbed blood, whereas regions uniform flow protected. Disturbed generates low, oscillatory wall shear stress (WSS) which promotes atherosclerosis by inducing EC expression inflammatory molecules. Conversely, high unidirectional WSS is protective. We studied the transcriptome low in porcine aorta using micro arrays observed differential multiple Homeobox (Hox) genes. These transcription factors regulate...
<h3>Introduction</h3> Atherosclerosis is influenced by local blood flow patterns, which exert wall shear stress (WSS) on endothelial cells (EC). Low, oscillatory WSS promotes atherosclerosis inducing EC proliferation and permeability, while high athero-protective. We recently used microarray technology coupled to computational fluid dynamics study the transcriptome of at regions porcine aorta exposed low, or high, unidirectional WSS. The revealed differential expression GATA4 Twist1. These...