A5066275412- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Catalysis for Biomass Conversion
- Glycosylation and Glycoproteins Research
- Analytical chemistry methods development
- Trypanosoma species research and implications
- Mercury impact and mitigation studies
- Enzyme Catalysis and Immobilization
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
- Pesticide Residue Analysis and Safety
- Asymmetric Hydrogenation and Catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Heavy metals in environment
- Cancer therapeutics and mechanisms
- Toxin Mechanisms and Immunotoxins
- Cancer Treatment and Pharmacology
- Toxic Organic Pollutants Impact
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Research on Leishmaniasis Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Bacteriophages and microbial interactions
Universidade de São Paulo
2007-2020
Laboratoire des Biomolécules
2019
Centre National de la Recherche Scientifique
2019
University of Bristol
2019
Sorbonne Université
2019
Instituto Nacional de Investigaciones Agropecuarias
2016
Ministry of Agriculture, Livestock, and Food Supply
2012-2015
John Innes Centre
2008
We demonstrate that tuning the reactivity of Cu by choice oxidation state and counterion leads to activation both "armed" "disarmed" type glycals toward direct glycosylation leading α-stereoselective synthesis deoxyglycosides in good excellent yields. Mechanistic studies show CuI is essential for effective catalysis stereocontrol reaction proceeds through dual enol ether as well OH nucleophile.
A very simple and rapid method for the determination of total mercury in fish samples using Direct Mercury Analyser DMA-80 was developed. In this system, a previously weighted portion fresh is combusted released selectively trapped gold amalgamator. Upon heating, desorbed from amalgamator, an atomic absorption measurement performed concentration calculated. Some experimental parameters have been studied optimised. study sample mass about 100.0 mg. The relative standard deviation lower than...
Abstract This study presents the synthesis of novel protected O‐glycosylated amino acid derivatives 1 and 2 , containing βGalNAc‐SerOBn βGalNAc‐ThrOBn units, respectively, as mimetics natural Tn antigen (αGalNAc‐Ser/Thr), along with solid‐phase assembly glycopeptides NHAcSer‐Ala‐Pro‐Asp‐Thr[αGalNAc]‐Arg‐Pro‐Ala‐Pro‐Gly‐BSA ( 3 ‐BSA) NHAcSer‐Ala‐Pro‐Asp‐Thr[βGalNAc]‐Arg‐Pro‐Ala‐Pro‐Gly‐BSA 4 ‐BSA), bearing αGalNAc‐Thr or βGalNAc‐Thr MUC1 tumor mucin glycoproteins. According to ELISA tests,...
Development and validation of a method for Cd Pb determination in fish shrimp by GF AAS, following sample freeze-drying TMAH solubilization.
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This work addresses the synthesis and biological evaluation of glycosyl diketopiperazines (DKPs) cyclo[Asp-(αGalNAc)Ser] 3 cyclo[Asp-(αGalNAc)Thr] 4 for development novel anti-trypanosomal agents Trypanosoma cruzi trans-sialidase (TcTS) inhibitors. The target compounds were synthetized by coupling reactions between amino acids αGalNAc-Ser 7 or αGalNAc-Thr 8 acid (O-tBu)-Asp 17, followed one-pot deprotection-cyclisation reaction in presence 20% piperidine DMF. protected intermediates were,...
A method for the determination of total mercury in fresh fish and shrimp samples by solid sampling thermal decomposition/amalgamation atomic absorption spectrometry (TDA AAS) has been validated following international foodstuff protocols order to fulfill Brazilian National Residue Control Plan. The experimental parameters have previously studied optimized according specific legislation on validation inorganic contaminants foodstuff. Linearity, sensitivity, specificity, detection...
We demonstrate that tuning the reactivity of Cu by choice oxidation state and counterion leads to activation both “armed” “disarmed” type glycals towards direct glycosylation leading a-stereoselective synthesis deoxyglycosides in good excellent yields. Mechanistic studies show CuI is essential for effective catalysis stereocontrol reaction proceeds through dual enol ether as well OH nucleophile.
We demonstrate that tuning the reactivity of Cu by choice oxidation state and counterion leads to activation both “armed” “disarmed” type glycals towards direct glycosylation leading a-stereoselective synthesis deoxyglycosides in good excellent yields. Mechanistic studies show CuI is essential for effective catalysis stereocontrol reaction proceeds through dual enol ether as well OH nucleophile.
We demonstrate that tuning the reactivity of Cu by choice oxidation state and counterion leads to activation both “armed” “disarmed” type glycals towards direct glycosylation leading a-stereoselective synthesis deoxyglycosides in good excellent yields. Mechanistic studies show CuI is essential for effective catalysis stereocontrol reaction proceeds through dual enol ether as well OH nucleophile.
<p><a></a>We demonstrate that tuning the reactivity of Cu by choice oxidation state and counterion leads to activation both “armed” “disarmed” type glycals towards direct glycosylation leading a-stereoselective synthesis deoxyglycosides in good excellent yields. Mechanistic studies show CuI is essential for effective catalysis stereocontrol reaction proceeds through dual enol ether as well OH nucleophile.</p>