A5077627178- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Sepsis Diagnosis and Treatment
- Mesenchymal stem cell research
- COVID-19 and healthcare impacts
- Palliative Care and End-of-Life Issues
- Neutropenia and Cancer Infections
- Long-Term Effects of COVID-19
- Zebrafish Biomedical Research Applications
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Intensive Care Unit Cognitive Disorders
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- Renal Transplantation Outcomes and Treatments
- Respiratory Support and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Dermatological and COVID-19 studies
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Emergency and Acute Care Studies
- Complement system in diseases
- Cerebrospinal fluid and hydrocephalus
University Medical Center Utrecht
2018-2025
Utrecht University
2023-2025
Erasmus MC
2013-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Maastricht University
2024
Amsterdam University Medical Centers
2021-2023
University of Amsterdam
2021-2023
Erasmus University Rotterdam
1996-2018
Franciscus Vlietland
2013-2015
In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which cause of coronavirus pandemic (Covid-2019). A large number these end up in intensive care units critical illness requiring mechanical ventilation. One most important clinical features infection a profound coagulopathy. recent cohort study, 71% who eventually died matched ISTH criteria for disseminated intravascular coagulation, while this percentage was only 0.6% survived.1 Although no data...
Since early in 2020, the first people Europe were infected with SARS-CoV-2 virus leading to COVID-2019 pandemic. In March we admitted patients a infection our hospital. Many of these eventually end up at intensive care unit (ICU). We and others have previously reported that ICU strikingly high rate thromboembolic complications ranging between 25% 35%.1-3 These hypercoagulable state admission on show mainly renal impairment as second organ involvement. Thrombotic microangiopathy (TMA) is one...
Abstract Background To assess trends in the quality of care for COVID-19 patients at ICU over course time Netherlands. Methods Data from National Intensive Care Evaluation (NICE)-registry all admitted to an Netherlands were used. Patient characteristics and indicators during first two upsurges (N = 4215: October 5, 2020–January 31, 2021) final upsurge second wave, called ‘third wave’ 4602: February 1, 2021–June 30, compared with those wave 2733, February–May 24, 2020). Results During third...
Abstract Background Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during final upsurge of second wave (February–June 2021) in Netherlands. We examined whether this decrease persisted third and phases decreasing incidence thereafter brought up to date information on patient characteristics. Methods Data from National Intensive Care Evaluation (NICE)-registry all an Netherlands used. Patient characteristics rates in-hospital (the...
Objectives: Historically, patients with a hematologic malignancy have one of the highest mortality rates among cancer admitted to ICU. Therefore, physicians are often reluctant admit these The aim our study was examine survival who and multiple organ failure Design: This retrospective cohort study, part HEMA-ICU group, designed after admission Patients were followed for at least 1 year. Setting: Five university hospitals in Netherlands. Patients: One-thousand ninety-seven Interventions:...
Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on optimal dosage of thromboprophylaxis critically ill COVID-19 patients. We utilized data from multicentre CAPACITY-COVID patient registry to assess effect differential application Low Molecular Weight Heparin (LMWH) dose protocols PE and in-hospital mortality risk An instrumental variable analysis was...
Throughout life, the hematopoietic system requires a supportive microenvironment that allows for maintenance and differentiation of stem cells (HSC). To understand cellular interactions molecules provide these functions, investigators have previously established stromal cell lines from late gestational stage adult murine microenvironments. However, supports emergence, expansion HSCs during mid-gestational stages has been largely unexplored. Since several tissues within mouse embryo are known...
Abstract Background Very few studies assessed the association between Intensive Care Unit (ICU) triage decisions and mortality. The aim of this study was to assess whether an could be found 30-day mortality, ICU admission consultation conditions decisions. Methods We conducted a retrospective cohort in two large referral university hospitals Netherlands. identified all adult cancer patients for whom requested from 2016 2019. Via multivariable logistic regression analysis, we Results Of 780...
Summary A few decades ago, the chances of survival for patients with a haematological malignancy needing Intensive Care Unit ( ICU ) support were minimal. As consequence, admission policy was cautious. We hypothesized that long‐term outcome admitted to has improved in recent years. Furthermore, our objective evaluate predictive value Acute Physiology and Chronic Health Evaluation APACHE II score. total 1095 from 5 Dutch university hospitals included 2003 until 2015. studied prevalence...
Describe the differences in characteristics and outcomes between COVID-19 other viral pneumonia patients admitted to Dutch ICUs.Data from National-Intensive-Care-Evaluation-registry of February 15th January 1th 2021 1st 2017 2020 were used. Patients' characteristics, unadjusted, adjusted in-hospital mortality compared.6343 2256 79 ICUs included. The included more male (71.3 vs 49.8%), had a higher Body-Mass-Index (28.1 25.5), less comorbidities (42.2 72.7%), prolonged hospital length stay...
Objective prognostic information is essential for good clinical decision making. In case of unknown diseases, scarcity evidence and limited tacit knowledge prevent obtaining this information. Prediction models can be useful, but need to not only evaluated on how well they predict, also stable these are under fast changing circumstances with respect development the disease corresponding response. This study aims provide interpretable actionable insights, particularly clinicians. We developed...
High variability in tacrolimus pharmacokinetics directly after lung transplantation (LuTx) may increase the risk for acute kidney injury (AKI) and transplant rejection. The primary objective was to compare pharmacokinetic patients receiving orally versus intravenously early LuTx.
Patients with haematological malignancies are at risk of concomitant critical neurological events warranting intensive care unit admission. We aimed to examine the characteristics and outcomes this patient population, as more knowledge could facilitate decision making on ICU admission treatment.A retrospective cohort study 68 patients in adult ICUs six Dutch university hospitals between 2003 2011.The median Acute Physiology Chronic Health Evaluation (APACHE) II score was 23 (IQR, 16-27), 77%...
To analyse the involvement of a possible numerical or qualitative stem cell defect in development sustained graft failure after autologous transplantation, we have determined content CD34+ nucleated cells, colony-forming cells and cobblestone area-forming subsets, as well transplant ability to produce progenitors using long-term culture (LTC-CFC) assay. We evaluated material from reference ampoules 13 patients bone marrow transplantation (BMT), four isolated thrombocytopenia peripheral blood...
To develop and validate a prediction model for 1-year mortality in patients with hematologic malignancy acutely admitted to the ICU.