A5100609687- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Soybean genetics and cultivation
- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Plant Stress Responses and Tolerance
- Antibiotics Pharmacokinetics and Efficacy
- Legume Nitrogen Fixing Symbiosis
- Tuberculosis Research and Epidemiology
- Advanced Drug Delivery Systems
- HIV Research and Treatment
- Genetic Neurodegenerative Diseases
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Pharmacological Effects and Toxicity Studies
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Lower Extremity Biomechanics and Pathologies
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Pesticide Residue Analysis and Safety
- Mycotoxins in Agriculture and Food
- Circular RNAs in diseases
- Selenium in Biological Systems
- HIV/AIDS drug development and treatment
Southern Medical University
2022-2025
Qingdao Agricultural University
2019-2025
University of California, San Francisco
2021-2025
Prince of Wales Hospital
2024
Chinese University of Hong Kong
2014-2024
Ministry of Agriculture and Rural Affairs
2023
Jiangnan University
2022-2023
State Key Laboratory of Food Science and Technology
2022-2023
Hong Kong Metropolitan University
2023
South China University of Technology
2022
In many aspects of life, epigenetics, or the altering phenotype without changes in sequences, play an essential role biological function. A vast number epigenomic datasets are emerging as a result advent next-generation sequencing. Annotation, comparison, visualization, and interpretation remain key computational biology. ChIPseeker is Bioconductor package for performing these analyses among variable datasets. The fundamental functions ChIPseeker, including data preparation, annotation,...
The identification of the conserved and variable regions in multiple sequence alignment (MSA) is critical to accelerating process understanding function genes. MSA visualizations allow us transform features into understandable visual representations. As sequence-structure-function relationship gains increasing attention molecular biology studies, simple display nucleotide or protein not satisfied. A more scalable visualization required broaden scope investigation. Here we present ggmsa, an R...
To obtain a comprehensive understanding of transcriptomic reprogramming under salt stress, we performed whole-transcriptome sequencing on the leaf and root soybean seedlings subjected to treatment in time-course experiment (0, 1, 2, 4, 24, 48 hr). This time series dataset enabled us identify important hubs connections gene expressions. We highlighted analysis phytohormone signaling pathways their possible crosstalks. Differential expressions were also found among those genes involved carbon...
Abstract White lupin ( Lupinus albus ) is a legume crop that develops cluster roots and has high phosphorus (P)-use efficiency (PUE) in low-P soils. Here, we assemble the genome of white find it evolved from whole-genome triplication (WGT) event. We then decipher its diploid ancestral reconstruct three sub-genomes. Based on results, further reveal sub-genome dominance genic expression different sub-genomes varying relation to their transposable element (TE) density. The PUE genes have been...
Abstract In metabarcoding research, such as taxon identification, phylogenetic placement plays a critical role. However, many existing methods lack comprehensive features for downstream analysis and visualization. Visualization tools often ignore uncertainty, making it difficult to explore interpret data effectively. To overcome these limitations, we introduce scalable approach using treeio ggtree parsing visualizing data. The ‐ method supports filtration, uncertainty exploration, customized...
Rhein, an anthraquinone compound existing in many traditional herbal medicines, has anti-inflammatory, antioxidant, antitumor, antiviral, hepatoprotective, and nephroprotective activities, but its anti-influenza A virus (IAV) activity is ambiguous. In the present study, through plaque inhibition assay, time-of-addition antioxidant qRT-PCR, ELISA, western blotting assays, we investigated anti-IAV effect mechanism of action rhein vitro vivo. The results showed that could significantly inhibit...
Plants that have experienced certain abiotic stress may gain tolerance to a similar in subsequent exposure. This phenomenon, called priming, was observed here soybean (Glycine max) seedlings exposed salt stress. Time-course transcriptomic profiles revealed distinctively different transcriptional responses the primed from those non-primed under high salinity stress, indicating response strategy of repressing unhelpful biotic and focusing on promotion important for tolerance. To identify...
Abstract In the face of global food security crises, it is necessary to boost agricultural production. One factor hampering attempts increase production elevated soil salinity, which can be due salt that naturally present in or a consequence excessive prolonged irrigation application fertiliser. response environmental stresses, plants activate multiple molecular mechanisms, including timely activation stress‐responsive transcriptional networks. However, case stress, combined effects initial...
Respiratory syncytial virus (RSV) infection is a constant threat to the health of young children, and this mainly attributed lack effective prevention strategies. This study aimed determine whether Lactobacillus (L.) mucosae, potential probiotic, could protect against respiratory viral in mouse model. Naive 3-4-week-old BALB/c mice were orally administered with three L. mucosae strains (2.5 × 108 CFU/mouse) 7 days before RSV (105 TCID50/mouse). Results showed that all inhibited replication...
1. Piperine, the major biological active component in black pepper has been associated with miscellaneous pharmacological effects, especially on central nervous system. To correlate its neurological activity, a comprehensive pharmacokinetic profile of piperine brain, plasma and cerebrospinal fluid after oral administration rats was investigated this study. 2. It noted that could efficiently penetrate homogeneously distribute into brain similar pharmacokinetics profiles each region. In...
Significance Small CAG (sCAG) RNAs are neurotoxic, but their role in polyglutamine degeneration remains to be fully elucidated. We observed that cellular expression of sCAGs is sufficient induce neuronal DNA damage and discovered the transcript level NUDT16 was reduced HD models. The protein has previously been linked pathway. At structural level, form double-stranded CAG–CUG heteroduplex RNA with which led its gene silencing. showed bisamidinium-based compound DB213 specifically interacts...
Accessible chromatin regions (ACRs) are tightly associated with gene expressions in the genome. Conserved non-coding cis-regulatory elements, such as transcription factor binding motifs, usually found ACRs, indicating an essential regulatory role of ACRs plant genome architecture. However, there have been few studies on soybean especially those focusing specific tissues. Hence, this study, convenient ATAC-seq, we identified six tissues, including root, leaf bud, flower, flower developing...
Background: Phase 2a trials in tuberculosis typically use early bactericidal activity (EBA), the decline sputum CFU over 14 days, as primary end-point for testing efficacy of drugs monotherapy. However, cost phase can range from USD 7 million to 19.6 on average, while >30% fail progress 3. Better utilising pre-clinical data predict and prioritise most likely succeed will thus help accelerate drug development reduce costs. We aim clinical EBA using vivo pharmacokinetic (PK)-pharmacodynamic...
Candida albicans and Cryptococcus neoformans, human-pathogenic fungi found worldwide, are receiving increasing attention due to high morbidity mortality in immunocompromised patients. In the present work, 110 fungus pairs were constructed by coculturing 16 wood-decaying basidiomycetes, among which coculture of Trametes robiniophila Murr Pleurotus ostreatus was strongly inhibit pathogenic through bioactivity-guided assays. A combination metabolomics molecular network analysis revealed that 44...