A5089807885- Parasites and Host Interactions
- Malaria Research and Control
- Adolescent Sexual and Reproductive Health
- Global Maternal and Child Health
- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Epilepsy research and treatment
- Child Nutrition and Water Access
- Tuberculosis Research and Epidemiology
- Vitamin C and Antioxidants Research
- Reproductive tract infections research
- Sex work and related issues
- HIV/AIDS Impact and Responses
- Mobile Health and mHealth Applications
- Whipple's Disease and Interleukins
- Antioxidant Activity and Oxidative Stress
- Mycobacterium research and diagnosis
- Vitamin D Research Studies
- Cytokine Signaling Pathways and Interactions
- Vaccine Coverage and Hesitancy
- HIV, Drug Use, Sexual Risk
- Digital Mental Health Interventions
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
Lusaka Apex Medical University
2019-2022
Right to Care
2020
World Health Organization - Zimbabwe
2002-2006
World Health Organization Regional Office for Africa
2006
Swiss Tropical and Public Health Institute
2003
Tropical Diseases Research Centre
1985-2003
World Health Organization
2003
Institut de Recherche Agricole pour le Développement
2002
Centers for Disease Control and Prevention
2002
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale
2002
Objective: The objective of this study was to explore whether the differences in rate spread HIV different regions sub-Saharan Africa could be explained by sexual behaviour and/or factors influencing probability transmission during intercourse. Methods: A cross-sectional, population-based conducted two cities with a high prevalence (Kisumu Kenya and Ndola Zambia) relatively low (Cotonou Benin Yaoundé Cameroon). In each these cities, approximately 1000 men women, aged 15-49 years, were...
To estimate parameters of concurrent sexual partnerships in five urban populations sub-Saharan Africa and to assess their association with levels HIV infection other sexually transmitted infections (STI).Data were obtained from a multicentre study factors which determine the differences rate spread African cities. Consenting participants interviewed on behaviour at four sites also provided blood urine sample for testing STI. Data included number 12 months preceding interview as well dates...
Some Ministries of Health in Africa plan to make blood slide microscopy available peripheral health centers improve malaria diagnosis over the current practice, which relies solely on clinical findings. To assess whether improves management febrile persons centers, we prospectively reviewed medical records all outpatients visiting six with laboratories Zambia during a 2-3-day period. Staff interviews and blinded review series slides from each facility by two expert microscopists were also...
Summary and conclusions In all regions of sub-Saharan Africa, the predominant mode transmission HIV is sexual intercourse between men women, but there are large variations in rate extent spread different populations. We set out to try identify factors that could explain why has more rapidly some parts Africa than others. To approach this question, we used a study design combined ecological comparisons across populations with individual-level analyses within The analysis allowed us explore...
Background: The main conclusion of the multicentre study on factors determining differential spread HIV in four African cities was that differences sexual behaviour could not, by themselves, explain prevalence between cities. present paper examines three potential sources bias invalidate this conclusion: (1) changes since start epidemics; (2) due to low response rates men; and (3) reported behaviour. Methods: To assess whether there have been any over time, selected parameters were compared...
Malaria poses a major health risk to people who are exposed infection in malaria-endemic areas. A randomized, double-blind, placebo-controlled study was conducted determine the efficacy and safety of Malarone (250 mg atovaquone/100 proguanil hydrochloride per tablet) for chemoprophylaxis Plasmodium falciparum malaria Zambia. Adult volunteers received three-day treatment course eliminate pre-existing parasitemia were then immediately randomized with either one tablet daily (n = 136), or...
Objectives: To estimate rates of condom use in four urban populations sub-Saharan Africa and to assess their association with levels HIV infection other sexually transmitted diseases (STDs). Methods: Data were obtained from a multicentre study factors that determine the differences rate spread African cities. Consenting participants interviewed on sexual behaviour, also provided blood urine samples for testing STDs. behaviour included information during all reported spousal non-spousal...
A prospective cohort study was conducted in two villages Zambia to compare the efficacy of praziquantel treatment schistosomiasis haematobium people with and without concomitant infection human immunodeficiency virus (HIV). Five hundred seven individuals infected Schistosoma were enrolled followed-up for as long 12 months after a single dose praziquantel. Seventy-three coinfected HIV. The demonstrated that is still very effective control S. even when there coinfection HIV (without symptoms...
User charges in public health facilities are aimed at improving efficiency and quality of services. In Africa, evidence about their effect on patient attendance community health-seeking behaviour mixed. This paper reports a study the user revenue collection, services people's relation to malaria Korogwe district, Tanzania. Data were collected through focus-group discussions with members, interviewing leaders workers, field observations review registers. Generally, there was no distinct...
Literature indicates a high prevalence and burden of mental illness in youths world-wide, which may be even higher low- middle-income countries (LMIC), such as South Africa Zambia. Additionally, there is lack knowledge regarding youth depression amongst many primary health care (PHC) practitioners. The principal goal the MEGA project to provide with better access services appropriate care, by developing screening mobile application tool used PHC settings In this study, we will use mixed...
Abstract Background: The spread of drug-resistant malaria and appreciation side effects associated with existing antimalarial drugs emphasize the need for new to prevent malaria. combination atovaquone proguanil hydrochloride was previously shown be safe highly effective treatment malaria, including multi-drug-resistant Plasmodium falciparum. Methods: We reviewed results clinical trials that evaluated either a fixed-dose prophylaxis or alone causal prophylactic activity against P. Results:...
Six hundred and ninety-three individuals from an area endemic for S. mansoni infection had parasitological physical examinations done. A morbidity questionnaire was also administered to each participant. Among those with infection, there a significant increase in watery diarrhoea, bloody blood stool hepatomegaly. The severity of the disease appears be directly related egg load therefore these results give further justification treatment high intensity age groups community based chemotherapy...
Studies from Asia and Europe indicate an association between vitamin D deficiency susceptibility to TB. We performed observational case-control study determine cathelicidin (LL-37) levels their with active TB in newly diagnosed microbiologically confirmed adult patients Zambia, a high HIV prevalence setting.
Background People living with HIV (PLHIV) co-infected tuberculosis (TB) have a distinct clinical presentation and poorer treatment outcomes compared to HIV-seronegative TB patients. Excluding low CD4 count, innate immune factors associated are not fully elucidated. We, therefore, characterised the expression of IL-6, TNF-α, IFN-γ, IL-10 in whole blood naïve patients stimulated heat-killed Mycobacterium stratified by status level count. Results We recruited 39 seropositive 31 seronegative...
Journal Article A three year follow-up of chemotherapy with praziquantel in a rural Zambian community endemic for schistosomiasis mansoni Get access T.Y. Sukwa, Sukwa ∗ Tropical Diseases Research Centre, P.O. Box 71769, Ndola, Zambia ∗Author correspondence. Search other works by this author on: Oxford Academic PubMed Google Scholar B.A. Boatin, Boatin F.K. Wurapa Transactions The Royal Society Medicine and Hygiene, Volume 82, Issue 2, March-April 1988, Pages 258–260,...
A community-based, double-blind, randomized trial of praziquantel was carried out in an area Zambia endemic for schistosomiasis. The aim the study to assess impact treatment on Schistosoma mansoni morbidity. total 377 infected children, aged seven 19 years, into two groups: one 190 (group A) and 187 B). All children were treated with 40 mg praziquantel/kg at start study. Six months later, group re-treated same dose praziquantel, while B given placebos. followed up three, six 12 after initial...
At the Tropical Diseases Research Centre, Ndola, Zambia, we have used “relative risks” to demonstrate relationship between intensity of Schistosoma mansoni infection and liver spleen enlargement. There was a significant trend in risk for both right left lobe enlargement across strata. However showed no trend.