A5041248955- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Bacterial Infections and Vaccines
- Transplantation: Methods and Outcomes
- Antenna Design and Analysis
- Renal Transplantation Outcomes and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Blood groups and transfusion
- Cytomegalovirus and herpesvirus research
- Fecal contamination and water quality
- Plant Virus Research Studies
- Mechanical Circulatory Support Devices
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- HIV/AIDS drug development and treatment
- Angiogenesis and VEGF in Cancer
- COVID-19 epidemiological studies
- Water Systems and Optimization
- Viral gastroenteritis research and epidemiology
- Immunodeficiency and Autoimmune Disorders
- Non-Invasive Vital Sign Monitoring
- Water Treatment and Disinfection
The Kids Research Institute Australia
2025
Seqirus (United States)
2023
Victorian Infectious Diseases Reference Laboratory
2012-2020
Peter Doherty Institute
2014-2020
The Royal Melbourne Hospital
2016-2020
GlaxoSmithKline (Australia)
2019-2020
The University of Melbourne
2020
Melbourne Health
2020
HIV Netherlands Australia Thailand Research Collaboration
2016
Monash University
2007-2013
Summary This study sought to assess the antiviral efficacy of lamivudine ( LMV ) administered during third trimester reduce maternal viraemia and identify emergence resistance. A prospective observational analysis was performed on 26 mothers with high viral load (>10 7 IU/mL). Twenty‐one women received (treated group) for an average 53 days (range 22–88 days), remaining five formed untreated control group. Serum samples from two time points were used measure HBV DNA levels drug The...
Hepatitis B e antigen (HBeAg) seroconversion and hepatitis surface (HBsAg) loss are important clinical outcomes for patients with chronic (CHB) treated antiviral therapy. To date, there have been few studies that evaluated viral sequence markers predicting serological response to nucleos(t)ide analogue (NA) treatment.We used next-generation sequencing (NGS) quantitative HBV serology (HBeAg HBsAg) identify associated long-term tenofovir disoproxil fumarate therapy among HBeAg-positive...
ABSTRACT The mechanisms by which hepatitis B virus (HBV) establishes and maintains chronic infection (CHB) are poorly defined. Innate immune responses play an important role in reducing HBV replication pathogenesis. has developed numerous to escape these responses, including the production of secreted e antigen (HBeAg), been shown regulate antiviral toll-like receptor (TLR) interleukin-1 (IL-1) signaling. IL-18 is a related cytokine that inhibits hepatoma cell lines liver through induction...
Understanding patterns of bacterial carriage and otitis media (OM) microbiology are crucial for assessing vaccine impact informing policy. The OM can vary with geography, time, interventions like pneumococcal conjugate vaccines (PCVs). We evaluated the nasopharyngeal middle ear effusions in children living Western Australia, 11 years following introduction PCV13. Children undergoing surgery recurrent acute and/or chronic effusion (cases), non-infectious reasons (controls), were recruited....
Objectives To investigate whether bicycle riding alters total prostate-specific antigen (tPSA) serum concentrations in healthy older men. Methods 129 male participants, ranging age from 50 to 71 years (mean 55 years), rode a recreational group ride of between and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, 5 after completing the ride. The pre-cycling post-cycling values log transformed normality compared using paired t-tests. Linear...
Improvements in cardiac transplant practice and immunosuppressive treatment have done much to curb the incidence of acute cellular rejection (ACR); however, antibody-mediated (AMR) allograft vasculopathy (CAV) remain prevalent. Recent studies shown that is governed by both allogeneic nonallogeneic factors such as inflammation. Initial suggested vascular endothelial growth factor (VEGF), a leukocyte mitogen produced activated cells leukocytes, may play specific role not only trafficking, but...
Hepatitis B virus (HBV) can persist in some HIV-HBV coinfected individuals on tenofovir disoproxil fumarate (TDF)-containing combination antiretroviral therapy (cART) but HBV resistance to TDF has not been reported and the source of persistent DNA is poorly understood. The aims this study were assess long-term suppression receiving investigate quasispecies variation using ultradeep pyrosequencing (UDPS).Ninety-two participants on, or about commence, TDF-containing cART enrolled [Australia (n...
Progressive multifocal leukoencephalopathy (PML) and JCV granular cell neuronopathy occur secondary to polyomavirus (JCV) infection of oligodendrocytes cerebellar neurons (CGNs) during immunosuppression. Pure populations astrocytes, oligodendrocytes, CGNs microglia from frontal cortex cerebellum 17 non-PML patients (9 immunocompetent; 8 immunosuppressed) were isolated by laser capture microdissection (LCM). large T (LT) antigen DNA was detected triple nested polymerase chain reaction (PCR)....
The relationship between latent JC polyomavirus (JCV) infection and progressive multifocal leukoencephalopathy (PML) remains unclear. In this study, JCV DNA was quantified by real-time polymerase chain reaction (qPCR) in brain kidney tissue from patients without PML. Immunosuppressed had significantly higher levels brain, compared with immunocompetent (P = .001). An inverse observed CD4+ T-cell counts qPCR-determined load among HIV (r2 –0.9; P .01; n 7). Higher strongly associated (Spearman...
Adult vaccination in Australia is suboptimal. For instance, as few one nine people have received a pertussis vaccine adolescence or adulthood, despite increasing disease burden and evidence of positive correlation between older age hospitalization rates. The objectives this study were to describe general practitioners' (GPs) adult consumers' knowledge attitudes toward vaccination, with an emphasis on pertussis. Australian GPs consumers recruited two nationally representative online surveys...
Journal Article Evaluation of an alternative method for the enumeration and confirmation Clostridium perfringens from treated untreated sewages Get access T. Wohlsen, Wohlsen Public Health Microbiology, Queensland Scientific Services, Queensland, AustraliaFaculty Science, Education, University Sunshine Coast, Australia Tracey P.O. Box 594, Archerfield, 4108, Australia. E‐mail: tracey_wohlsen@health.qld.gov.au Search other works by this author on: Oxford Academic Google Scholar J. Bayliss,...
Nucleos(t)ide analogues (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However, risk hepatocellular carcinoma (HCC) persists despite viral suppression. Specific HBV variants have been associated adverse outcomes, including HCC; however, the frequency these during seemingly benign immunotolerant (IT) phase is unknown. Next-generation sequencing and detailed virological characterization on a cohort treatment-naïve IT were performed to...
We conducted haplotype analysis of complete hepatitis B virus (HBV) genomes following deep sequencing from 368 patients across multiple phases chronic (CHB) infection four major genotypes (A-D), analyzing 4,110 haplotypes to identify viral variants associated with treatment outcome and disease progression.Between 18.2% 41.8% nucleotides between 5.9% 34.3% amino acids were 100% conserved in all examined, depending on the region analyzed. Hepatitis e antigen (HBeAg) loss by week 192 was...
The combined vaccine against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and Haemophilus influenzae b (DTPa-HBV-IPV/Hib, Infanrix Hexa, GSK) has been used for childhood immunization in Australia according to a two-, four-, six-month schedule since 2009. We reviewed data available the Australian National Notifiable Diseases Surveillance System, annual vaccination coverage reports, Database of Adverse Event Notifications, peer-reviewed literature assess rates, incidence all six...
Summary Background Hepatitis B e antigen ( HB eAg) seroconversion is a treatment endpoint for eAg‐positive CHB , and necessary precursor to sAg loss. Biomarkers that predict serological outcomes would be useful. Aim To evaluate the utility of measuring eAg levels predicting loss under long‐term tenofovir TDF ) therapy. Methods A total 266 patients were enrolled into phase III study vs adefovir ADV 48 weeks in patients, followed by open‐label up 384 weeks. Serum measured subjects with samples...
Summary Microchimerism is the presence of foreign cells in an individual below 1% total cells, which can occur setting solid organ transplantation. This study quantitated donor-derived cellular subsets longitudinally human leucocyte antigen (HLA)-mismatched lung transplant recipients (LTR) during first post-operative year and evaluated pattern peripheral microchimerism with clinical outcomes. Peripheral blood mononuclear (PBMC) isolated from non-HLA-B44 LTR who received HLA-B44 allografts...