A5076369814- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Peptidase Inhibition and Analysis
- Animal Nutrition and Physiology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Galectins and Cancer Biology
- Vasculitis and related conditions
- Pharmacological Effects of Natural Compounds
- Crop Yield and Soil Fertility
- Chemokine receptors and signaling
- Bone health and treatments
- Genetics and Plant Breeding
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Spondyloarthritis Studies and Treatments
- Veterinary medicine and infectious diseases
- Parasite Biology and Host Interactions
- Genetic Mapping and Diversity in Plants and Animals
Shahid Beheshti University of Medical Sciences
2015-2024
Ilam University
2015
Medical University of Ilam
2015
Shahid Beheshti University
2012
University of Idaho
2011
University of Guelph
2004-2005
Uppsala University
2005
Objective: Previous studies have shown that the bioflavonoid quercetin has anti-inflammatory and anti-nociceptive effects. We investigated effect of supplementation on inflammation, disease severity, clinical symptoms in women with rheumatoid arthritis (RA).Methods: The present study was a randomized, double-blind, placebo-controlled trial which 50 RA were allocated into (500 mg/day) or placebo group for 8 weeks. Plasma levels high-sensitivity tumor necrosis factor-α (hs-TNFα), erythrocyte...
Although heterosis in maize (Zea mays L.) has been studied since the early 1900s, very little is known about how affects physiological components of grain yield. The objective this study was to quantify basis for yield by examining hybrids and their parental inbred lines terms its component processes, dry matter accumulation (DMA) at maturity, partitioning DMA (i.e., harvest index), as well processes underlying those two components. genetic material consisted 12 seven lines. Experiments were...
Background: One of the most important concerns about systemic lupus erythematosus (SLE) is presence oral lesions, which in turn one diagnostic criteria for SLE. Regarding wide range lesions and absence comprehensive data Iran, this study aimed to evaluate prevalence mucosal related factors patients with SLE at three rheumatology clinics Tehran. Methods: This descriptive was performed on 188 by observation, clinical examination, completing questionnaire also evaluating patients’ medical...
Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of are extremely disabling treatment options limited. In this study, we aimed to assess the safety efficacy autologous fat grafting in face patients with sclerosis. We enrolled 16 SSc suffering from facial limited mouth opening capacity. Autologous injection ranging 15 40 ml was administered per patient, based on their morphology. The...
Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate an anti-folate drug that may be prescribed in some malignant or inflammatory conditions. The aim the current study was to compare signs symptoms, complications, treatment final outcome MTX toxicity. In a retrospective referral center between March 2010 2018, all patients who had been referred with history poisoning hospitalized due were evaluated compared. Of total 27 admitted during period, 13...
This study aimed to compare efficacy and safety of test-adalimumab (CinnoRA®, CinnaGen, Iran) the innovator product (Humira®, AbbVie, USA) in adult patients with active rheumatoid arthritis (RA). In this randomized, double-blind, active-controlled, non-inferiority trial, a total 136 RA were randomized receive 40 mg subcutaneous injections either CinnoRA® or Humira® every other week, while receiving methotrexate (15 mg/week), folic acid (1 mg/day), prednisolone (7.5 mg/day) over period 24...
Few studies have examined the inheritance and interrelationships of both grain yield underlying physiological processes in maize (Z ea mays L.). The objective this study was to establish genetic relationships between components examine its component (i.e., additive nonadditive effects). Twelve F 1 hybrids, obtained by mating three male four female inbred lines using a North Carolina Design II, were evaluated trials conducted Ontario from 2000 2002. Dry matter accumulation (DMA) at stages...
Abstract Objective: Rheumatoid arthritis is thought to induce conductive hearing loss and/or sensorineural loss. This study evaluated the function of middle ear and cochlea, related factors. Methods: Pure tone audiometry, speech reception thresholds, discrimination scores, tympanometry, acoustic reflexes, distortion product otoacoustic emissions were assessed in rheumatoid patients healthy volunteers. Results: audiometry results revealed a higher bone conduction threshold group, but there...
Heterosis for grain yield in maize (Zea mays L.) manifests itself through its effects on the components of yield, dry matter accumulation at maturity, harvest index, and physiological processes underlying these components, such as leaf CO2 exchange rate (CER). The objectives this study were (i) to quantify pattern CER throughout grain-filling period hybrids their parental inbred lines, (ii) determine mode inheritance during period. Studies performed with 12 F1 seven parents grown...
Abstract The positive impacts of β‐ d ‐mannuronic acid (M2000) on the gene expression miR‐155, its target molecules (SOCS1 and SHIP1), NF‐κB transcription factor were demonstrated in a study using HEK293‐TLR2 cell line. This new drug has been approved as safe effective medication by randomized, multinational, phase III clinical trial RA patients. present aimed to evaluate oral administration effect M2000 levels mentioned genes research was conducted 12 patients healthy individuals. After...
The Childiidae sensuDörjes 1968 comprises the acoel worms characterized by a cone-shaped penis with muscular or sclerotized elements. Based on differences in body-wall musculature arrangement, Hooge (2001) recently restricted family to genus Childia Graff, 1910 and placed remaining genera his new Actinoposthiidae 2001. This rearrangement has been questioned (Raikova et al. 2004). We reconstructed phylogeny of means total evidence analysis including Histone H3, 28S rDNA 18S sequences, as well...
Abstract COVID‐19 should be considered as a new triggering factor for autoimmune disorders like DM‐lupus overlap syndrome. We recommend that patients presenting with dermatomyositis during this pandemic screened COVID‐19.
Context: miR-146a, its targets (IRAK1, TRAF6) and NF-κB transcription factor play a fundamental role in rheumatoid arthritis (RA). Positive effects of drug β-d-mannuronic acid (M2000) were proven on their expression the HEK-Blue hTLR2 cell line, results phase III clinical trial RA patients encouraging.Objective: This research aimed to investigate M2000 these genes serum levels IL-6 TNF-α as pro-inflammatory cytokines patients.Material methods: In this study (Trial Registration Number:...
Using the same cutoff points for whole-body measurements as site-specific will result in underestimation of osteoporosis.We assessed correlation between densitometry whole body with those femur, lumbar spine, and forearm to evaluate possibility replacing values measurements.In this cross-sectional study, we evaluated all patients referred a single rheumatology clinic bone mineral density from 2009 2010. All who had taken hip, forearm, were enrolled study. Standard performed using dual energy...
Hemophagocytic lymphohistiocytosis (HLH) is a rare hematologic disease that occurs due to immune system dysfunction. Clinical manifestations of this are fever, increased ferritin level, cytopenia, and hemophagocytosis in the biopsy report bone marrow. We 36-year-old woman referred our hospital with persistent arthralgia interphalangeal joints, cutaneous rash on trunk, was subsequently diagnosed as an adult-onset Still's (AOSD), after marrow aspiration, HLH her.
Rheumatoid arthritis (RA) as a long-term autoimmune disease is characterized by pain, swelling and joints destruction. The therapeutic efficacy of Guluronic acid (G2013) (patented, DEU: 102016113017.6) was reported in phase I/II clinical trial RA patients. In this study, we aimed to evaluate the effect G2013 novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive property on genes expression pro-inflammatory cytokines their transcription factors blood sample patients.
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This open-label study investigated the safety and efficacy of tocilizumab in Middle Eastern patients with rheumatoid arthritis (RA). Patients whose Disease Activity Score based on 28 joints (DAS28) was >3.2 received 8 mg/kg intravenously every 4 weeks for 24 weeks. receiving aTNF ± nonbiologic disease-modifying antirheumatic drug(s) (DMARD(s)) switched to tocilizumab; DMARD monotherapy added tocilizumab. Primary end points were adverse events (AEs), serious AEs (SAEs), laboratory parameters;...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease which involves several organs.CD26 multifunctional molecule that has an extracellular domain with dipeptidyl peptidase IV activity digests crucial inflammatory molecules. CD26 plays important role in T-cell activation and enhances immune responses. This study was carried out to evaluate the level of gene expression SLE patients. Forty-six patients 44 healthy controls voluntarily participated this study. Based on index...