A5044393041- Characterization and Applications of Magnetic Nanoparticles
- Nanomaterials for catalytic reactions
- Advanced MRI Techniques and Applications
- Geomagnetism and Paleomagnetism Studies
- Nanoparticle-Based Drug Delivery
- Boron and Carbon Nanomaterials Research
- Advanced X-ray Imaging Techniques
- Microfluidic and Bio-sensing Technologies
- Cell Image Analysis Techniques
- Magnetic and Electromagnetic Effects
- Advanced Electron Microscopy Techniques and Applications
- Catalytic Processes in Materials Science
- Diamond and Carbon-based Materials Research
- NMR spectroscopy and applications
- Ammonia Synthesis and Nitrogen Reduction
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Body Composition Measurement Techniques
- Immune cells in cancer
- Supercapacitor Materials and Fabrication
- Metal and Thin Film Mechanics
- Inorganic and Organometallic Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Iron oxide chemistry and applications
- Catalysis and Hydrodesulfurization Studies
NanoPET Pharma (Germany)
2015-2021
Max Planck Society
2010-2014
Max Planck Institute of Colloids and Interfaces
2010-2014
An "easy-to-handle" Fe3C powder constituted of nanoparticles is prepared in a simple, fast and relatively cheap way. The are crystalline, small (d ≈ 8 nm), superparamagnetic. Despite the absence any significant coating shell, these stable against oxidation can represent perfect base for generation novel ferrofluids. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted...
The magnetic particle spectrum (MPS) of bacterial magnetosomes, isolated from Magnetospirillum gryphiswaldense, is measured and compared to that the current "gold standard", Resovist®. It shown amplitudes magnetosomes' harmonics by far exceed Resovist®; amplitude third harmonic higher a factor 7, highest value obtained for iron oxide nanoparticles date.
Mesoporous Fe3C is synthesised by combining a hard-templating approach with carbothermal reduction. The product shows high crystallinity, transport pore size of d ≈ 20 nm and specific surface area (415 m2 g−1). Its usefulness exemplified its catalytic activity stability in NH3 decomposition.
Novel Fe3C-based nanostructures with an inner layered structure have been synthesized by a simple medium-temperature (T = 700 °C) process based on carbothermal reduction. In this process, the iron precursor reacts selected nitrogen rich carbon source (namely, 4,5-dicyanoimidazole) to form wrapped nano-sheets of Fe3C@C(N). The nanosheets are composed 5 nm crystalline Fe3C nanoparticles, which integrated into nitrogen-doped phase giving rise morphology. By variation reaction parameters (such...
Superparamagnetic iron oxide nanoparticles (SPION) have a great potential in both diagnostic and therapeutic applications as they provide contrast magnetic resonance imaging techniques allow hyperthermia drug delivery. Though various types of SPION are commercially available, efforts to improve the quality highly demand. Here, we describe strategy for optimization synthesis under microfluidics using coprecipitation approach. Synthesis parameters such temperature, pH, salt concentration,...
Dispersions of Fe(3)C nanoparticles in several ionic liquids (ILs) have been investigated. The ILs are based on 1-ethyl-3-methylimidazolium [Emim] and 1-butyl-3-methylimidazolium [Bmim] cations. Anions ethylsulfate [ES], methanesulfonate [MS], trifluoromethylsulfonate (triflate) [TfO], tetrafluoroborate [BF(4)], dicyanamide [N(CN)(2)], thiocyanate [SCN]. Among the studied, [Emim][SCN] [Emim][N(CN)(2)] stand out because only these stable transparent nanoparticle dispersions obtained. All...
Iron oxide nanoparticles (ION) are highly sensitive probes for magnetic resonance imaging (MRI) that have previously been used in vivo cell tracking and enabled implementation of several diagnostic tools to detect monitor disease. However, the MRI signal ION can overlap with from endogenous iron, resulting a lack detection specificity. Therefore, long-term fate administered remains largely unknown, possible tissue deposition iron cannot be assessed established methods. Herein, we combine...
Although X-ray based 3D virtual histology is an emerging tool for the analysis of biological tissue, it falls short in terms specificity when compared to conventional histology. Thus, aim was establish a novel approach that combines information provided by microCT with high only (immuno-)histochemistry can offer. For this purpose, we developed software frontend, which utilises elastic transformation technique accurately co-register various histological and immunohistochemical stainings free...
In the field of regenerative medicine, we focus on repairing damaged tissue using appropriate cells for therapy that have healing capacities, such as human mesenchymal stem (hMSCs). Tissue will only be possible if can homed to their target. Beside cell homing at targeted organ, assessing vitality is paramount interest during process. To guarantee homing, hMSCs labeled long-term, noninvasive monitoring. Cell with iron oxide nanoparticles tracked various methods like magnetic particle imaging...
In the search for alternative materials to current expensive catalysts, Ni has been addressed as one of most promising and, on this trail, its corresponding nitride. However, nickel nitride is a thermally unstable compound, and therefore not easy prepare especially nanoparticles. present work, sol-gel-based process (the urea glass route) applied well-defined homogeneous Ni3N both cases, prepared crystalline nanoparticles (∼25 nm) are dispersed in carbon matrix forming interesting Ni3N-...
We herein developed a micro-CT method using the innovative contrast agent ExiTron™ MyoC 8000 to longitudinally monitor cardiac processes in vivo small animals. Experiments were performed on healthy mice and with myocardial infarction inflicted by ligation of left anterior descending artery. Time-dependent signal enhancement different tissues was measured various doses investigated so as determine minimum required dose for imaging myocardium. Due its ability be taken up myocardium but not...
Magnetic resonance imaging (MRI) and magnetic particle (MPI) are powerful methods in the early diagnosis of diseases. Both techniques utilize nanoparticles that have high susceptibility, strong saturation magnetization, no coercivity. FeraSpinTM R its fractionated products been studied for their performances; however, a detailed characterization immobilized state is still lacking. This particularly important applications MPI require fixation with target cells or tissues. We examine...
Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides known to penetrate across cell membranes. Here, we thus introduce system based on magnetite the polypeptide poly-l-arginine (polyR-Fe3O4). We show that hybrid exhibit low cytotoxicity is comparable Resovist®, commercially available drug. PolyR-Fe3O4 particles perform very well diagnostic such as magnetic particle imaging (1.7...
Fe3 N and C nanocomposites have a wide range of applications thanks to their ceramic nature, magnetic properties, conductivity catalytic activity, just cite some. In many fields optimal performances are ensured by crystallinity, homogeneity hierarchical organization. the present paper, crystalline, well-defined nanofibres iron nitride carbide/carbon nanocomposite with tunable composition size were prepared via electrospinning. The starting polymeric material was directly electrospun into...
A successful clinical translation of novel nanoparticle-based cancer therapeutics requires a thorough preclinical investigation their interaction with immune, tumor and endothelial cells as well components the tumor-microenvironment. Although high-resolution microscopy images fixed tissue specimens can provide valuable information in this regard, they are only static snapshots momentary event. Here we describe superior alternative fluorescence approach to assess feasibility investigating...
Abstract Although x-ray based 3D virtual histology is an emerging tool for the analysis of biological tissue, it falls short in terms specificity when compared to conventional histology. Thus, aim was establish a novel approach that combines information provided by microCT with high only (immuno-)histochemistry can offer. For this purpose, we developed software frontend, which utilises elastic transformation technique accurately co-register various histological and immunohistochemical...
To avoid the disadvantages of classical batch-wise coprecipitation in synthesis iron oxide nanoparticles we developed a microfluidic platform with continuous flow mode which enables faster and more efficient adjustment relevant parameters like pH-value, temperature educt concentration. Initial results electrostatically stabilized particles demonstrate high potential for use as tracer magnetic particle imaging or contrast agent resonance outperforming efficacy current gold-standard...