A5030389667- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Olfactory and Sensory Function Studies
- Hormonal Regulation and Hypertension
- Pregnancy and preeclampsia studies
- Menopause: Health Impacts and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Birth, Development, and Health
- Neonatal and fetal brain pathology
University of Tsukuba
2023
University of British Columbia
2019-2021
Queens College, CUNY
2020
Middle age represents a critical window for metabolic and cognitive health, particularly in the context of rising obesity diabetes rates. Glucagon-like peptide-1 (GLP-1)-based therapies, which regulate blood glucose body weight, show sex-specific effects, with estradiol potentiating their benefits. However, research on GLP-1s neuroprotective roles has largely been conducted males. Here, we investigated effects GLP-1 conjugated to (GE2) metabolism, cognition, inflammation neurogenesis...
The processing of information regarding the sex and reproductive state conspecific individuals is critical for successful reproduction survival in males. Generally, male mice exhibit a preference toward odor sexually receptive (RF) over nonreceptive females (XF) or gonadally intact males (IM). Previous studies suggested involvement estrogen receptor beta (ERβ) expressed medial amygdala (MeA) RF. To further delineate role played by ERβ MeA neuronal network regulating preference, we developed...
Abstract The processing of information regarding the sex and reproductive state conspecific individuals is critical for successful reproduction survival in males. Generally, male mice exhibit a preference towards sexually receptive (RF) over non-receptive females (XF) or gonadally intact males (IM). Previous studies suggested involvement estrogen receptor beta (ERβ) expressed medial amygdala (MeA) RF. To further delineate role played by ERβ MeA neuronal network regulating preference, we...
Abstract Oxytocin regulates social behaviours, pair bonding and hippocampal neurogenesis but most studies have used adult males. Our study investigated the effects of oxytocin on investigation in male female rats. has poor penetration blood-brain barrier, therefore we tested a nanoparticle drug, TRIOZAN TM (Ovensa Inc.), which permits greater blood-brain-barrier penetration. Adult rats were injected daily (i.p.) for 10 days with either: PBS (0.5 or 1.0 mg/kg), vehicle (PBS) investigation....
ABSTRACT Perinatal depression (PND) affects approximately 15% of women, and de novo postpartum 40% PND cases. Selective serotonin reuptake inhibitors (SSRIs) are a common class antidepressants prescribed to treat PND. However, the safety efficacy SSRIs have been questioned in both clinical preclinical research. Here, using rodent model depression, we aim better understand neuroinflammatory cytokines tryptophan mechanisms that may be related efficacy. Rodent dams were treated with high...
Abstract Perinatal depression (PND) affects 15% of mothers. Selective serotonin reuptake inhibitors (SSRIs) are currently the first-line treatment for PND but not always efficacious. Previously, we found significant reductions in plasma tryptophan concentrations and higher hippocampal proinflammatory cytokine, IL-1b levels, due to maternal SSRI treatment. Both inflammation tryptophan-kynurenine metabolic pathway (TKP) associated with efficacy individuals major depressive disorder (MDD). TKP...