A5103268470- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Protease and Inhibitor Mechanisms
- Plant Pathogens and Resistance
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Healthcare and Venom Research
- Molecular Biology Techniques and Applications
- Sulfur Compounds in Biology
- Cancer, Lipids, and Metabolism
- Cancer survivorship and care
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Palliative Care and End-of-Life Issues
- Renin-Angiotensin System Studies
- Empathy and Medical Education
- Pulmonary Hypertension Research and Treatments
Shanghai University of Traditional Chinese Medicine
2024
University of California, San Diego
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Wenzhou Medical University
2022
Wenzhou Medical University
2012-2022
Affiliated Hospital of Youjiang Medical University for Nationalities
2016-2020
Guangxi Medical University
2019
Nantong University
2018
Youjiang Medical College for Nationalities
2013-2017
Baise University
2017
MicroRNA-24 (miR-24) may be involved in neoplastic process; however, the role of this microRNA hepatocellular carcinoma (HCC) related to aflatoxin B1 (AFB1) has not been well elaborated. Here, we tested miR-24 expression 207 pathology-diagnosed HCC cases from high AFB1 exposure areas and cells. We found that was upregulated tumor tissues relative adjacent noncancerous tissue samples, significantly correlated with larger size, higher microvessel density, dedifferentiation. Additionally,...
Background: Genetic polymorphisms in DNA repair genes may influence individual variation capacity and play an important role carcinogenesis. We investigated the of genetic at XRCC4 codon 247 (rs3734091, XRCC4P) XRCC5 180 (rs80309960, XRCC5P) liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1). Methods: A hospital-based case-control study, including 1499 cases 2045 controls without any disease, was conducted a high exposure area Guangxi region China to assess relationship...
MicroRNA-429 (miR-429) may modify the development and progression of cancers; however, role this microRNA in hepatocellular carcinoma (HCC) has not been well elaborated. Here, we tested miR-429 expression 138 pathology-diagnosed HCC cases SMMC-7721 cells. We found that was upregulated tumor tissues high significantly correlated with larger size (odd ratio (OR), 2.70; 95% confidence interval (CI), 1.28-5.56) higher aflatoxin B1-DNA adducts (OR = 3.13, CI 1.47-6.67). Furthermore,...
X-ray repair complementing group 4 (XRCC4) is very important in maintaining overall genome stability and may play an role carcinogenesis. We aimed to investigate the of polymorphisms coding region this gene hepatocellular carcinoma (HCC) caused by aflatoxin B1 (AFB1). A hospital-based case-control study, including 1,499 HCC cases 2,045 controls without any liver diseases or tumors, was conducted a high AFB1 exposure area (the Guangxi region) assess relationship between 21 XRCC4 AFB1-related...
The serum microRNAs have been reported as potential biomarkers for hepatitis virus-related hepatocellular carcinoma (HCC); however, their role in aflatoxin B1 (AFB1)-related HCC to has not yet evaluated.We conducted a case-control study, including 366 cases and 662 controls without any evidence of tumors, identify assess diagnostic prognostic AFB1-related HCC. sensitivity, specificity, area under the receiver operating characteristic curve (AUC) were used elucidate performance, compare with...
Our recent investigation has shown that the variables of microRNA-1268a may involve in hepatocellular carcinoma (HCC) tumorigenesis. Here, we attempted to identify prognostic significance expression tumor tissues by a retrospective analysis 411 patients with HCC, and analyze its effects on post-operative adjuvant transarterial chemoembolization (TACE) improving HCC prognosis. All cases received resection or plus TACE as an initial treatment. Logistical regression exhibited was significantly...
The X-ray repair cross-complementing group 7 (XRCC7) plays an important role in the of DNA double-strand breaks by nonhomologous end-joining (NEJR) pathway. However, XRCC7 polymorphisms (rs#7003908 and rs#10109984) possibly influencing NEJR capacity hepatocellular carcinoma (HCC) induced aflatoxin B1 (AFB1) has not been well elaborated. This hospital-based case-control study, including 348 patients with newly diagnosed HCC 597 controls without any evidence liver diseases, was conducted to...
The altered expression of some microRNAs (miRNAs) is observed in hepatocellular carcinoma (HCC); however, the genetic polymorphisms precursor miRNAs (pre‐miRNAs) aflatoxin B1 (AFB1)‐related HCC have not yet been investigated. A hospital‐based case‐control study, including 1,706 cases and 2,270 controls without any liver diseases or tumors, was conducted a high AFB1 exposure area China to assess relationship between 48 pre‐miRNAs AFB1‐related risk prognosis. Among polymorphisms, only...
Altered expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is observed in hepatocellular carcinoma. The genetic polymorphisms this gene aflatoxin B1 (AFB1)-related carcinoma have not yet been elucidated.We conducted hospital-based case-control study, including 1,706 cases 2,270 controls without any liver diseases or tumors, to assess the association between 74 ADAMTS5 AFB1-related risk prognosis. Genotype, mRNA levels, TP53 mutation (TP53M) related AFB1...
Background: Limited data exist on bictegravir pharmacokinetics in pregnancy among persons with HIV (PWH) and infant washout. Setting: Nonrandomized, open-label, multi-center phase-IV prospective study of safety pregnant PWH their infants. Methods: Steady-state 24-hour pharmacokinetic sampling oral 50 mg once daily (a component fixed-dose combination bictegravir/emtricitabine/tenofovir alafenamide) during the 2 nd 3 rd trimesters postpartum was performed. Cord blood washout samples were...
Pulmonary sequestration is a relatively rare malformation. The incidence of common pyogenic infection in this anomaly very high. We describe non-symptomatic, 19-year-old man who was misdiagnosed with left lower lobe pneumonia, which treated antibiotics for nearly one month. Contrast-enhanced computed tomography (CT) multiplanar reconstruction showed an aberrant artery originated from the side descending aorta, and went through infiltration lobe. patient underwent surgical removal affected...
Altered expression of ataxin-3 (AT3) can modify DNA repair capacity and is observed in human diseases. The genetic polymorphisms this gene aflatoxin B1 (AFB1)-related liver cirrhosis (LC) have not yet been elucidated.We conducted a hospital-based case-control study, including 384 patients with LC 851 controls without any diseases, to assess the association between 264 AT3 AFB1-related risk. Genotype were tested using TaqMan-PCR or sequencing technique.We found three differentially...
Abstract Rationale: Extensive thrombosis in the portal venous system caused by hypereosinophilic syndrome (HES) is rare, and there no consensus on anticoagulant thrombolytic treatments for arteriovenous HES. Patient concerns: The clinical data of a patient with extensive his (superior mesenteric, splenic, hepatic, veins), renal artery thrombosis, mesenteric HES secondary gastrointestinal bleeding intestinal necrosis were retrospectively analyzed. Before admission, eosinophil count increased...
The X-ray repair cross-complementing group 7 (XRCC7) plays a key role in DNA that protects against genetic instability and carcinogenesis. To determine whether XRCC7 rs#7003908 polymorphism (XRCC7P) is associated with Helicobacter pylori ( H. ) infection-related gastric antrum adenocarcinoma (GAA) risk, we conducted hospital-based case-control study, including 642 patients pathologically confirmed GAA 927 individually matched controls without any evidence of tumours or precancerous lesions,...
Dihydroartemisinin (DHA) is a traditional antimalarial drug. DHA plays crucial role in preventing pulmonary hypertension (PH); however, its regulatory function on microRNAs (miRNAs) PH remains unclear. This study aimed to investigate whether exerts protective functions by regulating miR-335 PH. Hypoxia-induced models were induced both vitro and vivo. Mice treated with various concentrations of DHA, arterial smooth muscle cells (PASMCs) inhibitor, mimic, or Van Gogh-like 2 (Vangl2) plasmid....
Our previous reports have shown that microRNA-4651 is a potential early diagnostic and prognostic marker for hepatocellular carcinoma. We aimed to investigate whether modified postoperative adjuvant transarterial chemoembolization (pa-TACE) improve the prognosis of A hospital-based retrospective study, including 302 patients with advanced-stage carcinoma who received tumor resection or plus pa-TACE as an initial therapy, was conducted assess effects on treatment. MicroRNA-4651 expression in...
To explore the symptom experiences and influencing factors of gastrointestinal (GI) cancer patients on chemotherapy (CTX) in China.