A5021330575- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- interferon and immune responses
- Hepatitis B Virus Studies
Université Claude Bernard Lyon 1
2019-2022
Centre International de Recherche en Infectiologie
2019-2022
Inserm
2019-2022
Centre National de la Recherche Scientifique
2019-2022
Institut Pasteur
2019-2022
École Normale Supérieure de Lyon
2019-2022
A safe and protective Lassa virus vaccine is crucially needed in Western Africa to stem the recurrent outbreaks of infections Nigeria emergence previously unaffected countries, such as Benin Togo. Major challenges developing a include high diversity circulating strains their reemergence from 1 year another. To address each these challenges, we immunized cynomolgus monkeys with measles vector expressing glycoprotein nucleoprotein prototypic strain Josiah (MeV-NP). evaluate efficacy against...
Lassa virus (LASV) and Mopeia (MOPV) are two closely related, rodent-born mammarenaviruses. LASV is the causative agent of fever, a deadly hemorrhagic fever endemic in West Africa, whereas MOPV non-pathogenic humans. The Z matrix protein arenaviruses essential to assembly budding by recruiting host factors, mechanism that remains partially defined. To better characterize interactions involved, yeast two-hybrid screen was conducted using proteins from as bait. cellular ITCH WWP1, members...
Lassa virus (LASV), an Old World arenavirus, is responsible for hemorrhagic fevers in western Africa. The privileged tropism of LASV endothelial cells combined with a dysregulated inflammatory response are the main cause increase vascular permeability observed during disease. Mopeia (MOPV) another arenavirus closely related to but nonpathogenic non-human primates (NHPs) and has never been described humans. MOPV more immunogenic than NHPs vitro human immune cell models, intense type I IFN...