A5086324496- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
- Systemic Lupus Erythematosus Research
- Pharmaceutical Economics and Policy
- Mental Health and Patient Involvement
- Economic and Financial Impacts of Cancer
- Pharmaceutical Practices and Patient Outcomes
- Mental Health Treatment and Access
- Digital Mental Health Interventions
- Healthcare Policy and Management
- Monoclonal and Polyclonal Antibodies Research
- Biomedical Ethics and Regulation
- Healthcare cost, quality, practices
- Global Cancer Incidence and Screening
- Health and Medical Research Impacts
- Mental Health and Psychiatry
- Prenatal Screening and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Ethics in Clinical Research
- Musculoskeletal Disorders and Rehabilitation
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Frailty in Older Adults
- Immune Cell Function and Interaction
Manchester Academic Health Science Centre
2016-2025
University of Manchester
2014-2025
Primary Health Care
2019-2020
NIHR Manchester Biomedical Research Centre
2018-2019
Manchester University NHS Foundation Trust
2018-2019
Manchester University
2017
National Institute for Health Research
2017
To examine the risk of gastrointestinal (GI) bleeding, major stroke and systemic embolism associated with prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) to adults receiving oral anticoagulant (OAC) therapy.We conducted a population-based cohort study in OAC therapy using linked primary care (Clinical Practice Research Datalink GOLD) hospital (Hospital Episodes Statistics) electronic health records. We used cause-specific Cox regression models time-dependent NSAID treatment...
Narratives describing first‐hand experiences of recovery from mental health problems are widely available. Emerging evidence suggests that engaging with narratives can benefit people experiencing problems, but no randomized controlled trial has been conducted as yet. We developed the Narrative Experiences Online (NEON) Intervention, a web application providing self‐guided and recommender systems access to collection recorded (n=659). investigated whether NEON Intervention benefited adults...
Introduction: The advancement of precision medicine into routine clinical practice has been highlighted as an agenda for national and international health care policy. A principle barrier to this is in meeting requirements the payer or reimbursement agency care. This special report aims explain economic case medicine, by accounting explicit objectives defined decision-makers responsible allocation limited resources.Areas covered: framework cost-effectiveness analysis, a method evaluation,...
Objectives To estimate the number and burden of medication errors associated with prescription information transfer within National Health Service (NHS) in England impact implementing an interoperable system (a single digital prescribing record shared across NHS settings) reducing these errors. Methods We constructed a probabilistic mathematical model. estimated transition that would be undetected by standard medicines reconciliation, based on published literature, scaled this up annual...
Introduction Informal carers of people with mental health problems often have unmet support needs. Mental recovery narratives are increasingly accessible, but their relevance to and effect on informal been minimally investigated. The Narrative Experiences Online (NEON) Intervention is a first-in-field intervention that provides access diverse collection recorded narratives. This trial aimed examine the feasibility acceptability NEON for carers. Methods study involved two-arm randomized...
Abstract Objective Therapeutic drug monitoring (TDM) of tumour necrosis factor-α inhibitors (TNFi), by measuring levels and/or anti-drug antibodies, is being considered various international bodies to improve patient health outcomes and the value care for people with rheumatoid arthritis. Rheumatology providers may perceive barriers adopting TNFi TDM within their own clinical practice, limiting potential patients systems benefit. This study aimed explore perceived rheumatologists that reduce...
Background Digital health interventions (DHIs) are an established element of mental service provision internationally. Regulators have positioned the best practice standard evidence as interventional study with a comparator reflective care, often operationalized pragmatic trial. DHIs can extend to those not currently using services. Hence, for external validity, trials might openly recruit mixture people who used services and not. Prior research has demonstrated phenomenological differences...
To identify and quantify resource required associated costs for implementing TNF-α inhibitor (TNFi) drug level anti-drug antibody (ADAb) tests in UK rheumatology practice.A microcosting study, assuming the National Health Service perspective, identified direct medical with providing TNFi ADAb testing clinical practice. Resource use per patient were via four stages: identification of a pathway implications; estimation resources required; cost unit (2015 prices); calculation total patient....
Abstract Background Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in predicted immune cell frequency between active SLE patients, these are associated with clinical features and/or medication use. Methods Patients (BILAG-2004 Index) enrolled BILAG-Biologics Registry (BILAG-BR), prior to change therapy, were studied as part MASTERPLANS...
Paediatric otorrhoea (PO) is a symptom-based diagnosis encompassing acute and chronic ear infections that cause in children young people (CYP). To understand the burden of PO on primary care services. This was longitudinal population study UK care. Data from Clinical Practice Research Datalink (CPRD Aurum), January 2005 to December 2019, analysed. CYP <17 years age with were included. Standardised annual incidence presentation rates estimated. Poisson regression modelling used determine risk...
Management of rheumatoid arthritis (RA) relies on symptoms reported by patients during infrequent outpatient clinic visits. These reports are often incomplete and inaccurate due to poor recall, leading suboptimal treatment decisions outcomes. Asking people track in-between visits integrating the data into clinical pathways may improve this. However, knowledge how implement this practice its impact services outcomes remains scarce in RA. Therefore, we evaluate comparative effectiveness...
Background The increasing development and use of digital health interventions requires good quality costing information to inform commissioning choices about resource allocation decisions. Narrative Experiences Online (NEON) Intervention is a web-application that delivers recorded mental recovery narratives its users. Two randomized controlled trials are testing the NEON in people with experience psychosis experiencing non-psychosis problems (NEON-O). Aim This study describes estimates cost...
Gene therapy is an emerging type of treatment that may aim to provide a cure individuals with genetic mutation known be causative specific disease. A diagnosis the must precede in vivo gene therapy. Both achieving genomic-based and result substantial expenditures for health care systems. Uncertainties around costs, risks, benefits derived from subsequent suggests need developing evidence base, underpinned by opportunity cost, inform if, how, these technologies should introduced into systems...
Treatment decisions for any disease are usually informed by reference to published clinical guidelines or recommendations. These recommendations can be developed improve the relative cost-effectiveness of health care and reduce regional variation in practice. Anti-tumor necrosis factor alpha (anti-TNF) treatments prescribed people with rheumatoid arthritis according specific National Institute Health Care Excellence England. Evidence practice may indicate that different factors have an...
Primary endocrine therapy (PET) offers non-surgical treatment for older women with early-stage breast cancer who are unsuitable surgery due to frailty or comorbidity. This research assessed all-cause and cancer-specific mortality of PET vs. in (≥70 years) oestrogen-receptor-positive by comorbidity levels. study used UK secondary data analyse female patients from 2000 2016. Patients were censored until 31 May 2019 grouped the Charlson index (CCI) hospital risk score (HFRS). Cox regression...
Abstract Objective Identify and quantify the resource use cost per patient of performing a US-guided synovial tissue biopsy for people with RA within routine healthcare setting. Method A micro-costing study was performed from system perspective (National Health Service England). service pathway conceptual model described how procedure will be embedded care to inform management decisions. Consumables were estimated existing standard operating procedures biopsies. Staff time by expert input...