A5034410641- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Bipolar Disorder and Treatment
- Muscle and Compartmental Disorders
- Advanced Proteomics Techniques and Applications
- Healthcare Policy and Management
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Sarcoidosis and Beryllium Toxicity Research
- Mass Spectrometry Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Healthcare cost, quality, practices
- Erythropoietin and Anemia Treatment
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Primary Care and Health Outcomes
- Tuberculosis Research and Epidemiology
- Otitis Media and Relapsing Polychondritis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Extracellular vesicles in disease
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Angiogenesis and VEGF in Cancer
Salford Royal Hospital
2000-2024
ChemoCentryx (United States)
2023
Northern Health and Social Care Trust
2022
Salford Royal NHS Foundation Trust
2008-2021
Manchester Academic Health Science Centre
2015
University of Manchester
2015
University of Salford
2003-2012
New York Medical College
2004-2008
Renal Research Institute
2005-2007
Cornell University
2006
Endothelium-derived microparticles have recently been described as a new marker of endothelial cell dysfunction. Increased levels circulating documented in inflammatory disorders, diabetes mellitus, and many cardiovascular diseases. Perturbations angiogenesis play an important role the pathogenesis these disorders. We demonstrated previously that isolated (EMPs) impair function vitro, diminishing acetylcholine-induced vasorelaxation nitric oxide production by rat aortic rings simultaneously...
The urinary proteome in health and disease attracts increasing attention because of the potential diagnostic pathophysiologic biomarker information carried by specific excreted proteins or their constellations. This cross-sectional study aimed to analyze patients with biopsy-proven acute rejection (<i>n</i> = 23) compared transplant recipients stable graft function 22) healthy volunteers 20) correlate this clinical, morphologic, laboratory data. Urine samples were preadsorbed on four...
Chronic kidney diseases are accompanied by the accumulation of substances like asymmetric dimethylarginine, phenylacetic acid, homocysteine, and advanced glycation end products, known to either inhibit endothelial nitric oxide synthase (eNOS) or uncouple it, consequently limiting amount available (NO). Reduced bioavailability NO induces dysfunction. An early loss peritubular capillaries in tubulointerstitial fibrotic areas injury cells have been linked progressive renal disease. Screening...
We previously demonstrated that 4.7 kDa and 4.4 peptides are useful in diagnosing acute rejection renal transplant recipients. The aim of this study was to characterize these polypeptides assess their potential as biomarkers. were identified human beta-Defensin-1 (4.7 kDa) alpha-1-antichymotrypsin (4.4 kDa), by tandem mass spectrometry ProteinChip immunoassay. urinary abundance both polypeptides, assessed using surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF MS),...
The response to steroid therapy is used characterize the idiopathic nephrotic syndrome (INS) of childhood as either steroid-sensitive (SSNS) or steroid-resistant (SRNS), a classification with better prognostic capability than renal biopsy. majority (approximately 80%) INS due minimal change disease but percentage focal and segmental glomerulosclerosis increasing. We applied new technological platform examine urine proteome determine if different urinary protein excretion profiles could...
The pathogenesis of progressive renal allograft injury, which is termed chronic nephropathy (CAN), remains obscure and currently defined by histology. Prospective protocol-biopsy trials have demonstrated that clinical standard laboratory tests are insufficiently sensitive indicators the development progression CAN. study aim was to determine if CAN could be characterized urinary proteomic data identify proteins associated with disease. proteome 75 transplant recipients 20 healthy volunteers...
Background: The advancement of COVID-19 vaccination programs globally has been viewed as an integral strategy to reduce both the number cases and consequential complications COVID-19, particularly for high-risk patient groups. There are limited data on antibody response protection from disease infection severity in patients requiring hemodialysis (HD) following during Delta Omicron variant predominance. We conducted a study aiming evaluate humoral immunity derived two different vaccines...
Abstract Background Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in predicted immune cell frequency between active SLE patients, these are associated with clinical features and/or medication use. Methods Patients (BILAG-2004 Index) enrolled BILAG-Biologics Registry (BILAG-BR), prior to change therapy, were studied as part MASTERPLANS...
Abstract Background Patients undergoing haemodialysis (HD) are at higher risk of developing worse outcomes if they contract COVID-19. In our renal service we reduced HD frequency from thrice to twice-weekly in selected patients with the primary aim reducing COVID 19 exposure and transmission between patients. Methods Dialysis unit nephrologists identified 166 suitable (38.4% population) temporarily convert immediately prior peak COVID-19 pandemic area. Changes pre-dialysis weight, systolic...
<b><i>Background:</i></b> Best practice in dialysis is synthesised clear international guidelines. However, a large gap remains between the guidelines and actual delivery of care. In this paper, we report outcomes for first year multifaceted improvement programme our network. <b><i>Methods:</i></b> One collaborative involving 3 haemodialysis units peritoneal (PD) 299 patients. Each unit addressed different indicator (unit A - catheter-related...
Myosin heavy chain-9-related disorders (MYH9-RDs) are a group of autosomal-dominant caused by mutations in the MYH9 gene. The features include congenital macrothrombocytopaenia, inclusion bodies neutrophils and variable risk developing sensorineural deafness, progressive renal impairment presenile cataracts. A 44-year-old Caucasian man was initially thought to have Alport's syndrome thrombocytopaenia secondary idiopathic thrombocytopaenic purpura (ITP). detailed family history genetic...
We present a case of 71-year-old woman who initially presented with renal-limited antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Following standard therapy cyclophosphamide, steroids and plasma exchange, her renal function began to improve. However, despite appropriate treatment, subsequently deteriorated she suffered haemoptysis. Owing diagnostic uncertainty, bronchoscopy repeat biopsy were performed. The washings demonstrated positivity for cytomegalovirus (CMV) DNA, in...
COVID-19 vaccination has changed the landscape of pandemic; however, decreased uptake due to vaccine hesitancy been observed, particularly in patients from minority ethnic backgrounds and socially deprived areas. These patient characteristics are common on Renal Replacement Therapy (RRT), a population at extremely high risk developing serious illness who would thus benefit most programme. We designed bespoke programme for our RRT with aim decreasing health inequalities increasing uptake.Key...
Maintenance dialysis is a relatively low prevalence, highly specialized, and labour-intensive treatment, which usually delivered at regional centres serving many different health authorities. It unknown whether patient's authority, in ways an accident of birth, influences long-term outcomes.To study survival patterns patients starting maintenance therapy the north-west England between 1990 1999.Retrospective analysis.We analysed data from quarterly returns submitted to West Pennine Health...